ROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination pathway through CSB

Transcription-coupled homologous recombination (TC-HR) is activated by reactive oxygen species-induced DNA damage to maintain transcribed genome stability. The authors demonstrate that R loops are induced by ROS at the transcribed genome, triggering a CSB-RAD52- dependent but BRCA1/2-independent RAD...

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Autores principales:	Yaqun Teng, Tribhuwan Yadav, Meihan Duan, Jun Tan, Yufei Xiang, Boya Gao, Jianquan Xu, Zhuobin Liang, Yang Liu, Satoshi Nakajima, Yi Shi, Arthur S. Levine, Lee Zou, Li Lan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6df57d01d9cd4272a9ddbb25bd5cd4fe
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spelling	oai:doaj.org-article:6df57d01d9cd4272a9ddbb25bd5cd4fe2021-12-02T17:32:47ZROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination pathway through CSB10.1038/s41467-018-06586-32041-1723https://doaj.org/article/6df57d01d9cd4272a9ddbb25bd5cd4fe2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06586-3https://doaj.org/toc/2041-1723Transcription-coupled homologous recombination (TC-HR) is activated by reactive oxygen species-induced DNA damage to maintain transcribed genome stability. The authors demonstrate that R loops are induced by ROS at the transcribed genome, triggering a CSB-RAD52- dependent but BRCA1/2-independent RAD51 loading for repair.Yaqun TengTribhuwan YadavMeihan DuanJun TanYufei XiangBoya GaoJianquan XuZhuobin LiangYang LiuSatoshi NakajimaYi ShiArthur S. LevineLee ZouLi LanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yaqun Teng Tribhuwan Yadav Meihan Duan Jun Tan Yufei Xiang Boya Gao Jianquan Xu Zhuobin Liang Yang Liu Satoshi Nakajima Yi Shi Arthur S. Levine Lee Zou Li Lan ROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination pathway through CSB
description	Transcription-coupled homologous recombination (TC-HR) is activated by reactive oxygen species-induced DNA damage to maintain transcribed genome stability. The authors demonstrate that R loops are induced by ROS at the transcribed genome, triggering a CSB-RAD52- dependent but BRCA1/2-independent RAD51 loading for repair.
format	article
author	Yaqun Teng Tribhuwan Yadav Meihan Duan Jun Tan Yufei Xiang Boya Gao Jianquan Xu Zhuobin Liang Yang Liu Satoshi Nakajima Yi Shi Arthur S. Levine Lee Zou Li Lan
author_facet	Yaqun Teng Tribhuwan Yadav Meihan Duan Jun Tan Yufei Xiang Boya Gao Jianquan Xu Zhuobin Liang Yang Liu Satoshi Nakajima Yi Shi Arthur S. Levine Lee Zou Li Lan
author_sort	Yaqun Teng
title	ROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination pathway through CSB
title_short	ROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination pathway through CSB
title_full	ROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination pathway through CSB
title_fullStr	ROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination pathway through CSB
title_full_unstemmed	ROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination pathway through CSB
title_sort	ros-induced r loops trigger a transcription-coupled but brca1/2-independent homologous recombination pathway through csb
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/6df57d01d9cd4272a9ddbb25bd5cd4fe
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ROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination pathway through CSB

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