Anomeric memory of the glycosidic bond upon fragmentation and its consequences for carbohydrate sequencing

Establishing generic carbohydrate sequencing methods is both a major scientific challenge and a strategic priority. Here the authors show a hybrid analytical approach integrating molecular spectroscopy and mass spectrometry to resolve carbohydrate isomerism, anomeric configuration, regiochemistry an...

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Autores principales: Baptiste Schindler, Loïc Barnes, Gina Renois, Christopher Gray, Stéphane Chambert, Sébastien Fort, Sabine Flitsch, Claire Loison, Abdul-Rahman Allouche, Isabelle Compagnon
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/6dfa9ac8493147ec8c1e0cf50935da8d
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Sumario:Establishing generic carbohydrate sequencing methods is both a major scientific challenge and a strategic priority. Here the authors show a hybrid analytical approach integrating molecular spectroscopy and mass spectrometry to resolve carbohydrate isomerism, anomeric configuration, regiochemistry and stereochemistry.