Bromelain Extract Exerts Antiarthritic Effects via Chondroprotection and the Suppression of TNF-α–Induced NF-κB and MAPK Signaling

Bromelain, a mixture of proteases in pineapple rhizome, has beneficial biological properties. Following absorption, the compound remains biologically active in mammalian blood and tissues. Bromelain has multiple clinical and therapeutic applications because of its anti-arthritic activities. Anti-inf...

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Autores principales:	Peraphan Pothacharoen, Rujirek Chaiwongsa, Theerawut Chanmee, Orapin Insuan, Thanchanok Wongwichai, Phornpimon Janchai, Pilanee Vaithanomsat
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	anti-arthritis anti-inflammation bromelain chondroprotection osteoarthritis rheumatoid arthritis Botany QK1-989
Acceso en línea:	https://doaj.org/article/6dfb754c4eea4f97bccc00f4b7f75240
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spelling	oai:doaj.org-article:6dfb754c4eea4f97bccc00f4b7f752402021-11-25T18:44:38ZBromelain Extract Exerts Antiarthritic Effects via Chondroprotection and the Suppression of TNF-α–Induced NF-κB and MAPK Signaling10.3390/plants101122732223-7747https://doaj.org/article/6dfb754c4eea4f97bccc00f4b7f752402021-10-01T00:00:00Zhttps://www.mdpi.com/2223-7747/10/11/2273https://doaj.org/toc/2223-7747Bromelain, a mixture of proteases in pineapple rhizome, has beneficial biological properties. Following absorption, the compound remains biologically active in mammalian blood and tissues. Bromelain has multiple clinical and therapeutic applications because of its anti-arthritic activities. Anti-inflammation is one of the putative therapeutic effects of bromelain on osteoarthritis (OA) and rheumatoid arthritis (RA), but the molecular mechanisms in cartilage and synovial fibroblast has not been reported. Thus, in this study, interleukin (IL)-1β/oncostatin M-induced porcine cartilage and TNF-α–induced synovial fibroblast were used as the inflamed OA and RA models, respectively. The results demonstrated the chondroprotective effects of bromelain on cartilage degradation and the downregulation of inflammatory cytokine (tumor necrosis factor (TNF)-α, IL-1β, IL-6, IL-8) expression in TNF-α–induced synovial fibroblasts by suppressing NF-κB and MAPK signaling. The evidence from this study supported and explained the anti-inflammatory and analgesic effects of bromelain on arthritis in animal models and clinical studies.Peraphan PothacharoenRujirek ChaiwongsaTheerawut ChanmeeOrapin InsuanThanchanok WongwichaiPhornpimon JanchaiPilanee VaithanomsatMDPI AGarticleanti-arthritisanti-inflammationbromelainchondroprotectionosteoarthritisrheumatoid arthritisBotanyQK1-989ENPlants, Vol 10, Iss 2273, p 2273 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anti-arthritis anti-inflammation bromelain chondroprotection osteoarthritis rheumatoid arthritis Botany QK1-989
spellingShingle	anti-arthritis anti-inflammation bromelain chondroprotection osteoarthritis rheumatoid arthritis Botany QK1-989 Peraphan Pothacharoen Rujirek Chaiwongsa Theerawut Chanmee Orapin Insuan Thanchanok Wongwichai Phornpimon Janchai Pilanee Vaithanomsat Bromelain Extract Exerts Antiarthritic Effects via Chondroprotection and the Suppression of TNF-α–Induced NF-κB and MAPK Signaling
description	Bromelain, a mixture of proteases in pineapple rhizome, has beneficial biological properties. Following absorption, the compound remains biologically active in mammalian blood and tissues. Bromelain has multiple clinical and therapeutic applications because of its anti-arthritic activities. Anti-inflammation is one of the putative therapeutic effects of bromelain on osteoarthritis (OA) and rheumatoid arthritis (RA), but the molecular mechanisms in cartilage and synovial fibroblast has not been reported. Thus, in this study, interleukin (IL)-1β/oncostatin M-induced porcine cartilage and TNF-α–induced synovial fibroblast were used as the inflamed OA and RA models, respectively. The results demonstrated the chondroprotective effects of bromelain on cartilage degradation and the downregulation of inflammatory cytokine (tumor necrosis factor (TNF)-α, IL-1β, IL-6, IL-8) expression in TNF-α–induced synovial fibroblasts by suppressing NF-κB and MAPK signaling. The evidence from this study supported and explained the anti-inflammatory and analgesic effects of bromelain on arthritis in animal models and clinical studies.
format	article
author	Peraphan Pothacharoen Rujirek Chaiwongsa Theerawut Chanmee Orapin Insuan Thanchanok Wongwichai Phornpimon Janchai Pilanee Vaithanomsat
author_facet	Peraphan Pothacharoen Rujirek Chaiwongsa Theerawut Chanmee Orapin Insuan Thanchanok Wongwichai Phornpimon Janchai Pilanee Vaithanomsat
author_sort	Peraphan Pothacharoen
title	Bromelain Extract Exerts Antiarthritic Effects via Chondroprotection and the Suppression of TNF-α–Induced NF-κB and MAPK Signaling
title_short	Bromelain Extract Exerts Antiarthritic Effects via Chondroprotection and the Suppression of TNF-α–Induced NF-κB and MAPK Signaling
title_full	Bromelain Extract Exerts Antiarthritic Effects via Chondroprotection and the Suppression of TNF-α–Induced NF-κB and MAPK Signaling
title_fullStr	Bromelain Extract Exerts Antiarthritic Effects via Chondroprotection and the Suppression of TNF-α–Induced NF-κB and MAPK Signaling
title_full_unstemmed	Bromelain Extract Exerts Antiarthritic Effects via Chondroprotection and the Suppression of TNF-α–Induced NF-κB and MAPK Signaling
title_sort	bromelain extract exerts antiarthritic effects via chondroprotection and the suppression of tnf-α–induced nf-κb and mapk signaling
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6dfb754c4eea4f97bccc00f4b7f75240
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Bromelain Extract Exerts Antiarthritic Effects via Chondroprotection and the Suppression of TNF-α–Induced NF-κB and MAPK Signaling

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