Translational control by DHX36 binding to 5′UTR G-quadruplex is essential for muscle stem-cell regenerative functions

Translational control by DHX36 binding to 5′UTR G-quadruplex is essential for muscle stem-cell regenerative functions

Skeletal muscle stem cells (or satellite cells, SCs) are normally quiescent but activate and expand in response to injury. Here the authors show that induction of DHX36 helicase during SC activation promotes mRNA translation by binding to 5′UTR mRNA G-quadruplexes (rG4) in targets including Gnai2 an...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Xiaona Chen, Jie Yuan, Guang Xue, Silvia Campanario, Di Wang, Wen Wang, Xi Mou, Shiau Wei Liew, Mubarak Ishaq Umar, Joan Isern, Yu Zhao, Liangqiang He, Yuying Li, Christopher J. Mann, Xiaohua Yu, Lei Wang, Eusebio Perdiguero, Wei Chen, Yuanchao Xue, Yoshikuni Nagamine, Chun Kit Kwok, Hao Sun, Pura Muñoz-Cánoves, Huating Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/6dfdbd5e24c94a98ae8d2a286fba0f68
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:6dfdbd5e24c94a98ae8d2a286fba0f68
record_format dspace
spelling oai:doaj.org-article:6dfdbd5e24c94a98ae8d2a286fba0f682021-12-02T18:01:16ZTranslational control by DHX36 binding to 5′UTR G-quadruplex is essential for muscle stem-cell regenerative functions10.1038/s41467-021-25170-w2041-1723https://doaj.org/article/6dfdbd5e24c94a98ae8d2a286fba0f682021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25170-whttps://doaj.org/toc/2041-1723Skeletal muscle stem cells (or satellite cells, SCs) are normally quiescent but activate and expand in response to injury. Here the authors show that induction of DHX36 helicase during SC activation promotes mRNA translation by binding to 5′UTR mRNA G-quadruplexes (rG4) in targets including Gnai2 and unwinding them.Xiaona ChenJie YuanGuang XueSilvia CampanarioDi WangWen WangXi MouShiau Wei LiewMubarak Ishaq UmarJoan IsernYu ZhaoLiangqiang HeYuying LiChristopher J. MannXiaohua YuLei WangEusebio PerdigueroWei ChenYuanchao XueYoshikuni NagamineChun Kit KwokHao SunPura Muñoz-CánovesHuating WangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xiaona Chen
Jie Yuan
Guang Xue
Silvia Campanario
Di Wang
Wen Wang
Xi Mou
Shiau Wei Liew
Mubarak Ishaq Umar
Joan Isern
Yu Zhao
Liangqiang He
Yuying Li
Christopher J. Mann
Xiaohua Yu
Lei Wang
Eusebio Perdiguero
Wei Chen
Yuanchao Xue
Yoshikuni Nagamine
Chun Kit Kwok
Hao Sun
Pura Muñoz-Cánoves
Huating Wang
Translational control by DHX36 binding to 5′UTR G-quadruplex is essential for muscle stem-cell regenerative functions
description Skeletal muscle stem cells (or satellite cells, SCs) are normally quiescent but activate and expand in response to injury. Here the authors show that induction of DHX36 helicase during SC activation promotes mRNA translation by binding to 5′UTR mRNA G-quadruplexes (rG4) in targets including Gnai2 and unwinding them.
format article
author Xiaona Chen
Jie Yuan
Guang Xue
Silvia Campanario
Di Wang
Wen Wang
Xi Mou
Shiau Wei Liew
Mubarak Ishaq Umar
Joan Isern
Yu Zhao
Liangqiang He
Yuying Li
Christopher J. Mann
Xiaohua Yu
Lei Wang
Eusebio Perdiguero
Wei Chen
Yuanchao Xue
Yoshikuni Nagamine
Chun Kit Kwok
Hao Sun
Pura Muñoz-Cánoves
Huating Wang
author_facet Xiaona Chen
Jie Yuan
Guang Xue
Silvia Campanario
Di Wang
Wen Wang
Xi Mou
Shiau Wei Liew
Mubarak Ishaq Umar
Joan Isern
Yu Zhao
Liangqiang He
Yuying Li
Christopher J. Mann
Xiaohua Yu
Lei Wang
Eusebio Perdiguero
Wei Chen
Yuanchao Xue
Yoshikuni Nagamine
Chun Kit Kwok
Hao Sun
Pura Muñoz-Cánoves
Huating Wang
author_sort Xiaona Chen
title Translational control by DHX36 binding to 5′UTR G-quadruplex is essential for muscle stem-cell regenerative functions
title_short Translational control by DHX36 binding to 5′UTR G-quadruplex is essential for muscle stem-cell regenerative functions
title_full Translational control by DHX36 binding to 5′UTR G-quadruplex is essential for muscle stem-cell regenerative functions
title_fullStr Translational control by DHX36 binding to 5′UTR G-quadruplex is essential for muscle stem-cell regenerative functions
title_full_unstemmed Translational control by DHX36 binding to 5′UTR G-quadruplex is essential for muscle stem-cell regenerative functions
title_sort translational control by dhx36 binding to 5′utr g-quadruplex is essential for muscle stem-cell regenerative functions
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/6dfdbd5e24c94a98ae8d2a286fba0f68
work_keys_str_mv AT xiaonachen translationalcontrolbydhx36bindingto5utrgquadruplexisessentialformusclestemcellregenerativefunctions
AT jieyuan translationalcontrolbydhx36bindingto5utrgquadruplexisessentialformusclestemcellregenerativefunctions
AT guangxue translationalcontrolbydhx36bindingto5utrgquadruplexisessentialformusclestemcellregenerativefunctions
AT silviacampanario translationalcontrolbydhx36bindingto5utrgquadruplexisessentialformusclestemcellregenerativefunctions
AT diwang translationalcontrolbydhx36bindingto5utrgquadruplexisessentialformusclestemcellregenerativefunctions
AT wenwang translationalcontrolbydhx36bindingto5utrgquadruplexisessentialformusclestemcellregenerativefunctions
AT ximou translationalcontrolbydhx36bindingto5utrgquadruplexisessentialformusclestemcellregenerativefunctions
AT shiauweiliew translationalcontrolbydhx36bindingto5utrgquadruplexisessentialformusclestemcellregenerativefunctions
AT mubarakishaqumar translationalcontrolbydhx36bindingto5utrgquadruplexisessentialformusclestemcellregenerativefunctions
AT joanisern translationalcontrolbydhx36bindingto5utrgquadruplexisessentialformusclestemcellregenerativefunctions
AT yuzhao translationalcontrolbydhx36bindingto5utrgquadruplexisessentialformusclestemcellregenerativefunctions
AT liangqianghe translationalcontrolbydhx36bindingto5utrgquadruplexisessentialformusclestemcellregenerativefunctions
AT yuyingli translationalcontrolbydhx36bindingto5utrgquadruplexisessentialformusclestemcellregenerativefunctions
AT christopherjmann translationalcontrolbydhx36bindingto5utrgquadruplexisessentialformusclestemcellregenerativefunctions
AT xiaohuayu translationalcontrolbydhx36bindingto5utrgquadruplexisessentialformusclestemcellregenerativefunctions
AT leiwang translationalcontrolbydhx36bindingto5utrgquadruplexisessentialformusclestemcellregenerativefunctions
AT eusebioperdiguero translationalcontrolbydhx36bindingto5utrgquadruplexisessentialformusclestemcellregenerativefunctions
AT weichen translationalcontrolbydhx36bindingto5utrgquadruplexisessentialformusclestemcellregenerativefunctions
AT yuanchaoxue translationalcontrolbydhx36bindingto5utrgquadruplexisessentialformusclestemcellregenerativefunctions
AT yoshikuninagamine translationalcontrolbydhx36bindingto5utrgquadruplexisessentialformusclestemcellregenerativefunctions
AT chunkitkwok translationalcontrolbydhx36bindingto5utrgquadruplexisessentialformusclestemcellregenerativefunctions
AT haosun translationalcontrolbydhx36bindingto5utrgquadruplexisessentialformusclestemcellregenerativefunctions
AT puramunozcanoves translationalcontrolbydhx36bindingto5utrgquadruplexisessentialformusclestemcellregenerativefunctions
AT huatingwang translationalcontrolbydhx36bindingto5utrgquadruplexisessentialformusclestemcellregenerativefunctions
_version_ 1718378996167606272

Ejemplares similares