Interactions of genetic variants and prenatal stress in relation to the risk for recurrent respiratory infections in children

Abstract Genetic variants may predispose children to recurrent respiratory infections (RRIs) but studies on genotype-environment interaction are rare. We hypothesized that the risk for RRIs is elevated in children with innate immune gene variants, and that prenatal exposure to maternal psychological...

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Autores principales:	Laura S. Korhonen, Minna Lukkarinen, Katri Kantojärvi, Panu Räty, Hasse Karlsson, Tiina Paunio, Ville Peltola, Linnea Karlsson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6dff29a78109453991f8846b56740294
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spelling	oai:doaj.org-article:6dff29a78109453991f8846b567402942021-12-02T14:26:57ZInteractions of genetic variants and prenatal stress in relation to the risk for recurrent respiratory infections in children10.1038/s41598-021-87211-02045-2322https://doaj.org/article/6dff29a78109453991f8846b567402942021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87211-0https://doaj.org/toc/2045-2322Abstract Genetic variants may predispose children to recurrent respiratory infections (RRIs) but studies on genotype-environment interaction are rare. We hypothesized that the risk for RRIs is elevated in children with innate immune gene variants, and that prenatal exposure to maternal psychological distress further increases the risk. In a birth cohort, children with RRIs (n = 96) were identified by the age of 24 months and compared with the remaining cohort children (n = 894). The risk for RRIs in children with preselected genetic variants and the interaction between maternal distress during pregnancy and child genotype were assessed with logistic regression. The IL6 minor allele G was associated with elevated risk for RRIs (OR 1.55; 95% CI 1.14–2.12). Overall, there was no interaction between maternal psychological distress and child genotype. Exploratory analyses showed that, the association between the variant type of IL6 and the risk for RRIs was dependent on prenatal exposure to maternal psychological distress in males (OR 1.96; 95% CI 1.04–3.67). Our study didn’t find genotype-environment interaction between prenatal maternal distress and child genotype. Exploratory analyses suggest sex differences in gene-environment interaction related to susceptibility to RRIs.Laura S. KorhonenMinna LukkarinenKatri KantojärviPanu RätyHasse KarlssonTiina PaunioVille PeltolaLinnea KarlssonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Laura S. Korhonen Minna Lukkarinen Katri Kantojärvi Panu Räty Hasse Karlsson Tiina Paunio Ville Peltola Linnea Karlsson Interactions of genetic variants and prenatal stress in relation to the risk for recurrent respiratory infections in children
description	Abstract Genetic variants may predispose children to recurrent respiratory infections (RRIs) but studies on genotype-environment interaction are rare. We hypothesized that the risk for RRIs is elevated in children with innate immune gene variants, and that prenatal exposure to maternal psychological distress further increases the risk. In a birth cohort, children with RRIs (n = 96) were identified by the age of 24 months and compared with the remaining cohort children (n = 894). The risk for RRIs in children with preselected genetic variants and the interaction between maternal distress during pregnancy and child genotype were assessed with logistic regression. The IL6 minor allele G was associated with elevated risk for RRIs (OR 1.55; 95% CI 1.14–2.12). Overall, there was no interaction between maternal psychological distress and child genotype. Exploratory analyses showed that, the association between the variant type of IL6 and the risk for RRIs was dependent on prenatal exposure to maternal psychological distress in males (OR 1.96; 95% CI 1.04–3.67). Our study didn’t find genotype-environment interaction between prenatal maternal distress and child genotype. Exploratory analyses suggest sex differences in gene-environment interaction related to susceptibility to RRIs.
format	article
author	Laura S. Korhonen Minna Lukkarinen Katri Kantojärvi Panu Räty Hasse Karlsson Tiina Paunio Ville Peltola Linnea Karlsson
author_facet	Laura S. Korhonen Minna Lukkarinen Katri Kantojärvi Panu Räty Hasse Karlsson Tiina Paunio Ville Peltola Linnea Karlsson
author_sort	Laura S. Korhonen
title	Interactions of genetic variants and prenatal stress in relation to the risk for recurrent respiratory infections in children
title_short	Interactions of genetic variants and prenatal stress in relation to the risk for recurrent respiratory infections in children
title_full	Interactions of genetic variants and prenatal stress in relation to the risk for recurrent respiratory infections in children
title_fullStr	Interactions of genetic variants and prenatal stress in relation to the risk for recurrent respiratory infections in children
title_full_unstemmed	Interactions of genetic variants and prenatal stress in relation to the risk for recurrent respiratory infections in children
title_sort	interactions of genetic variants and prenatal stress in relation to the risk for recurrent respiratory infections in children
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6dff29a78109453991f8846b56740294
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Interactions of genetic variants and prenatal stress in relation to the risk for recurrent respiratory infections in children

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