Synergistic enzymatic and bioorthogonal reactions for selective prodrug activation in living systems

The side effects of cancer drugs limit their utility. Here, the authors developed a method in which an inactive (prodrug) version of the cancer drug doxorubicin enters tumour cells and then gets activated inside the cells upon a trigger facilitated by enzyme-instructed supramolecular self-assembly.

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Autores principales:	Qingxin Yao, Feng Lin, Xinyuan Fan, Yanpu Wang, Ye Liu, Zhaofei Liu, Xingyu Jiang, Peng R. Chen, Yuan Gao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6e007d35dea8437d9308ae7e95626469
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spelling	oai:doaj.org-article:6e007d35dea8437d9308ae7e956264692021-12-02T16:49:54ZSynergistic enzymatic and bioorthogonal reactions for selective prodrug activation in living systems10.1038/s41467-018-07490-62041-1723https://doaj.org/article/6e007d35dea8437d9308ae7e956264692018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07490-6https://doaj.org/toc/2041-1723The side effects of cancer drugs limit their utility. Here, the authors developed a method in which an inactive (prodrug) version of the cancer drug doxorubicin enters tumour cells and then gets activated inside the cells upon a trigger facilitated by enzyme-instructed supramolecular self-assembly.Qingxin YaoFeng LinXinyuan FanYanpu WangYe LiuZhaofei LiuXingyu JiangPeng R. ChenYuan GaoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qingxin Yao Feng Lin Xinyuan Fan Yanpu Wang Ye Liu Zhaofei Liu Xingyu Jiang Peng R. Chen Yuan Gao Synergistic enzymatic and bioorthogonal reactions for selective prodrug activation in living systems
description	The side effects of cancer drugs limit their utility. Here, the authors developed a method in which an inactive (prodrug) version of the cancer drug doxorubicin enters tumour cells and then gets activated inside the cells upon a trigger facilitated by enzyme-instructed supramolecular self-assembly.
format	article
author	Qingxin Yao Feng Lin Xinyuan Fan Yanpu Wang Ye Liu Zhaofei Liu Xingyu Jiang Peng R. Chen Yuan Gao
author_facet	Qingxin Yao Feng Lin Xinyuan Fan Yanpu Wang Ye Liu Zhaofei Liu Xingyu Jiang Peng R. Chen Yuan Gao
author_sort	Qingxin Yao
title	Synergistic enzymatic and bioorthogonal reactions for selective prodrug activation in living systems
title_short	Synergistic enzymatic and bioorthogonal reactions for selective prodrug activation in living systems
title_full	Synergistic enzymatic and bioorthogonal reactions for selective prodrug activation in living systems
title_fullStr	Synergistic enzymatic and bioorthogonal reactions for selective prodrug activation in living systems
title_full_unstemmed	Synergistic enzymatic and bioorthogonal reactions for selective prodrug activation in living systems
title_sort	synergistic enzymatic and bioorthogonal reactions for selective prodrug activation in living systems
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/6e007d35dea8437d9308ae7e95626469
work_keys_str_mv	AT qingxinyao synergisticenzymaticandbioorthogonalreactionsforselectiveprodrugactivationinlivingsystems AT fenglin synergisticenzymaticandbioorthogonalreactionsforselectiveprodrugactivationinlivingsystems AT xinyuanfan synergisticenzymaticandbioorthogonalreactionsforselectiveprodrugactivationinlivingsystems AT yanpuwang synergisticenzymaticandbioorthogonalreactionsforselectiveprodrugactivationinlivingsystems AT yeliu synergisticenzymaticandbioorthogonalreactionsforselectiveprodrugactivationinlivingsystems AT zhaofeiliu synergisticenzymaticandbioorthogonalreactionsforselectiveprodrugactivationinlivingsystems AT xingyujiang synergisticenzymaticandbioorthogonalreactionsforselectiveprodrugactivationinlivingsystems AT pengrchen synergisticenzymaticandbioorthogonalreactionsforselectiveprodrugactivationinlivingsystems AT yuangao synergisticenzymaticandbioorthogonalreactionsforselectiveprodrugactivationinlivingsystems
_version_	1718383163104821248

Synergistic enzymatic and bioorthogonal reactions for selective prodrug activation in living systems

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