Coagulation Disorders in COVID-19: Role of Toll-like Receptors

Indranil Biswas,1 Gausal A Khan2 1Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA; 2Department of Physiology & Physiotherapy, College of Medicine, Nursing and Health Sciences, Fiji National University, Suva, Fiji IslandsCorresponden...

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Autores principales:	Biswas I, Khan GA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	covid-19 coagulation disorders tlr3 tissue factor. Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/6e04b6fa14454de1a37bf12f8d3d0769
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spelling	oai:doaj.org-article:6e04b6fa14454de1a37bf12f8d3d07692021-12-02T12:56:01ZCoagulation Disorders in COVID-19: Role of Toll-like Receptors1178-7031https://doaj.org/article/6e04b6fa14454de1a37bf12f8d3d07692020-10-01T00:00:00Zhttps://www.dovepress.com/coagulation-disorders-in-covid-19-role-of-toll-like-receptors-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Indranil Biswas,1 Gausal A Khan2 1Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA; 2Department of Physiology & Physiotherapy, College of Medicine, Nursing and Health Sciences, Fiji National University, Suva, Fiji IslandsCorrespondence: Gausal A KhanDepartment of Physiology & Physiotherapy, College of Medicine, Nursing and Health Sciences, Fiji National University, Suva, Fiji IslandsEmail gausalk@gmail.comAbstract: Coronavirus disease 2019 (COVID-19) has spread rapidly throughout the world. The range of the disease is broad but among hospitalized patients with COVID-19 are coagulation disorders, pneumonia, respiratory failure, and acute respiratory distress syndrome (ARDS). The excess production of early response proinflammatory cytokines results in what has been described as a cytokine storm, leading to an increased risk of thrombosis, inflammations, vascular hyperpermeability, multi-organ failure, and eventually death over time. As the pandemic is spreading and the whole picture is not yet clear, we highlight the importance of coagulation disorders in COVID-19 infected subjects and summarize it. COVID-19 infection could induce coagulation disorders leading to clot formation as well as pulmonary embolism with detrimental effects in patient recovery and survival. Coagulation and inflammation are closely related. In this review, we try to establish an association between virus infections associated with innate immune activation, inflammation and coagulation activation.Keywords: COVID-19, coagulation disorders, TLR3, tissue factorBiswas IKhan GADove Medical Pressarticlecovid-19coagulation disorderstlr3tissue factor.PathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 13, Pp 823-828 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	covid-19 coagulation disorders tlr3 tissue factor. Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	covid-19 coagulation disorders tlr3 tissue factor. Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Biswas I Khan GA Coagulation Disorders in COVID-19: Role of Toll-like Receptors
description	Indranil Biswas,1 Gausal A Khan2 1Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA; 2Department of Physiology & Physiotherapy, College of Medicine, Nursing and Health Sciences, Fiji National University, Suva, Fiji IslandsCorrespondence: Gausal A KhanDepartment of Physiology & Physiotherapy, College of Medicine, Nursing and Health Sciences, Fiji National University, Suva, Fiji IslandsEmail gausalk@gmail.comAbstract: Coronavirus disease 2019 (COVID-19) has spread rapidly throughout the world. The range of the disease is broad but among hospitalized patients with COVID-19 are coagulation disorders, pneumonia, respiratory failure, and acute respiratory distress syndrome (ARDS). The excess production of early response proinflammatory cytokines results in what has been described as a cytokine storm, leading to an increased risk of thrombosis, inflammations, vascular hyperpermeability, multi-organ failure, and eventually death over time. As the pandemic is spreading and the whole picture is not yet clear, we highlight the importance of coagulation disorders in COVID-19 infected subjects and summarize it. COVID-19 infection could induce coagulation disorders leading to clot formation as well as pulmonary embolism with detrimental effects in patient recovery and survival. Coagulation and inflammation are closely related. In this review, we try to establish an association between virus infections associated with innate immune activation, inflammation and coagulation activation.Keywords: COVID-19, coagulation disorders, TLR3, tissue factor
format	article
author	Biswas I Khan GA
author_facet	Biswas I Khan GA
author_sort	Biswas I
title	Coagulation Disorders in COVID-19: Role of Toll-like Receptors
title_short	Coagulation Disorders in COVID-19: Role of Toll-like Receptors
title_full	Coagulation Disorders in COVID-19: Role of Toll-like Receptors
title_fullStr	Coagulation Disorders in COVID-19: Role of Toll-like Receptors
title_full_unstemmed	Coagulation Disorders in COVID-19: Role of Toll-like Receptors
title_sort	coagulation disorders in covid-19: role of toll-like receptors
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/6e04b6fa14454de1a37bf12f8d3d0769
work_keys_str_mv	AT biswasi coagulationdisordersincovid19roleoftolllikereceptors AT khanga coagulationdisordersincovid19roleoftolllikereceptors
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Coagulation Disorders in COVID-19: Role of Toll-like Receptors

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