Independent duplications of the Golgi phosphoprotein 3 oncogene in birds

Abstract Golgi phosphoprotein 3 (GOLPH3) was the first reported oncoprotein of the Golgi apparatus. It was identified as an evolutionarily conserved protein upon its discovery about 20 years ago, but its function remains puzzling in normal and cancer cells. The GOLPH3 gene is part of a group of gene...

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Autores principales:	Juan C. Opazo, Michael W. Vandewege, Javier Gutierrez, Kattina Zavala, Luis Vargas-Chacoff, Francisco J. Morera, Gonzalo A. Mardones
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6e06b473a6814f258457f97a5f3b48d7
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spelling	oai:doaj.org-article:6e06b473a6814f258457f97a5f3b48d72021-12-02T17:24:22ZIndependent duplications of the Golgi phosphoprotein 3 oncogene in birds10.1038/s41598-021-91909-62045-2322https://doaj.org/article/6e06b473a6814f258457f97a5f3b48d72021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91909-6https://doaj.org/toc/2045-2322Abstract Golgi phosphoprotein 3 (GOLPH3) was the first reported oncoprotein of the Golgi apparatus. It was identified as an evolutionarily conserved protein upon its discovery about 20 years ago, but its function remains puzzling in normal and cancer cells. The GOLPH3 gene is part of a group of genes that also includes the GOLPH3L gene. Because cancer has deep roots in multicellular evolution, studying the evolution of the GOLPH3 gene family in non-model species represents an opportunity to identify new model systems that could help better understand the biology behind this group of genes. The main goal of this study is to explore the evolution of the GOLPH3 gene family in birds as a starting point to understand the evolutionary history of this oncoprotein. We identified a repertoire of three GOLPH3 genes in birds. We found duplicated copies of the GOLPH3 gene in all main groups of birds other than paleognaths, and a single copy of the GOLPH3L gene. We suggest there were at least three independent origins for GOLPH3 duplicates. Amino acid divergence estimates show that most of the variation is located in the N-terminal region of the protein. Our transcript abundance estimations show that one paralog is highly and ubiquitously expressed, and the others were variable. Our results are an example of the significance of understanding the evolution of the GOLPH3 gene family, especially for unraveling its structural and functional attributes.Juan C. OpazoMichael W. VandewegeJavier GutierrezKattina ZavalaLuis Vargas-ChacoffFrancisco J. MoreraGonzalo A. MardonesNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Juan C. Opazo Michael W. Vandewege Javier Gutierrez Kattina Zavala Luis Vargas-Chacoff Francisco J. Morera Gonzalo A. Mardones Independent duplications of the Golgi phosphoprotein 3 oncogene in birds
description	Abstract Golgi phosphoprotein 3 (GOLPH3) was the first reported oncoprotein of the Golgi apparatus. It was identified as an evolutionarily conserved protein upon its discovery about 20 years ago, but its function remains puzzling in normal and cancer cells. The GOLPH3 gene is part of a group of genes that also includes the GOLPH3L gene. Because cancer has deep roots in multicellular evolution, studying the evolution of the GOLPH3 gene family in non-model species represents an opportunity to identify new model systems that could help better understand the biology behind this group of genes. The main goal of this study is to explore the evolution of the GOLPH3 gene family in birds as a starting point to understand the evolutionary history of this oncoprotein. We identified a repertoire of three GOLPH3 genes in birds. We found duplicated copies of the GOLPH3 gene in all main groups of birds other than paleognaths, and a single copy of the GOLPH3L gene. We suggest there were at least three independent origins for GOLPH3 duplicates. Amino acid divergence estimates show that most of the variation is located in the N-terminal region of the protein. Our transcript abundance estimations show that one paralog is highly and ubiquitously expressed, and the others were variable. Our results are an example of the significance of understanding the evolution of the GOLPH3 gene family, especially for unraveling its structural and functional attributes.
format	article
author	Juan C. Opazo Michael W. Vandewege Javier Gutierrez Kattina Zavala Luis Vargas-Chacoff Francisco J. Morera Gonzalo A. Mardones
author_facet	Juan C. Opazo Michael W. Vandewege Javier Gutierrez Kattina Zavala Luis Vargas-Chacoff Francisco J. Morera Gonzalo A. Mardones
author_sort	Juan C. Opazo
title	Independent duplications of the Golgi phosphoprotein 3 oncogene in birds
title_short	Independent duplications of the Golgi phosphoprotein 3 oncogene in birds
title_full	Independent duplications of the Golgi phosphoprotein 3 oncogene in birds
title_fullStr	Independent duplications of the Golgi phosphoprotein 3 oncogene in birds
title_full_unstemmed	Independent duplications of the Golgi phosphoprotein 3 oncogene in birds
title_sort	independent duplications of the golgi phosphoprotein 3 oncogene in birds
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6e06b473a6814f258457f97a5f3b48d7
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Independent duplications of the Golgi phosphoprotein 3 oncogene in birds

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