In vitro generation of functional murine heart organoids via FGF4 and extracellular matrix

Our understanding of the development of the heart has been limited by a lack of in vitro cellular models. Here, the authors treat mouse embryonic stem cell-derived embryoid bodies with laminin-entactin (to mimic the developing microenvironment) and FGF4 to form heart organoids, with atrial and ventr...

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Autores principales:	Jiyoung Lee, Akito Sutani, Rin Kaneko, Jun Takeuchi, Tetsuo Sasano, Takashi Kohda, Kensuke Ihara, Kentaro Takahashi, Masahiro Yamazoe, Tomohiro Morio, Tetsushi Furukawa, Fumitoshi Ishino
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6e0a5c1a58564f4ca225428e30d3056d
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spelling	oai:doaj.org-article:6e0a5c1a58564f4ca225428e30d3056d2021-12-02T15:27:34ZIn vitro generation of functional murine heart organoids via FGF4 and extracellular matrix10.1038/s41467-020-18031-52041-1723https://doaj.org/article/6e0a5c1a58564f4ca225428e30d3056d2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18031-5https://doaj.org/toc/2041-1723Our understanding of the development of the heart has been limited by a lack of in vitro cellular models. Here, the authors treat mouse embryonic stem cell-derived embryoid bodies with laminin-entactin (to mimic the developing microenvironment) and FGF4 to form heart organoids, with atrial and ventricular-like parts.Jiyoung LeeAkito SutaniRin KanekoJun TakeuchiTetsuo SasanoTakashi KohdaKensuke IharaKentaro TakahashiMasahiro YamazoeTomohiro MorioTetsushi FurukawaFumitoshi IshinoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jiyoung Lee Akito Sutani Rin Kaneko Jun Takeuchi Tetsuo Sasano Takashi Kohda Kensuke Ihara Kentaro Takahashi Masahiro Yamazoe Tomohiro Morio Tetsushi Furukawa Fumitoshi Ishino In vitro generation of functional murine heart organoids via FGF4 and extracellular matrix
description	Our understanding of the development of the heart has been limited by a lack of in vitro cellular models. Here, the authors treat mouse embryonic stem cell-derived embryoid bodies with laminin-entactin (to mimic the developing microenvironment) and FGF4 to form heart organoids, with atrial and ventricular-like parts.
format	article
author	Jiyoung Lee Akito Sutani Rin Kaneko Jun Takeuchi Tetsuo Sasano Takashi Kohda Kensuke Ihara Kentaro Takahashi Masahiro Yamazoe Tomohiro Morio Tetsushi Furukawa Fumitoshi Ishino
author_facet	Jiyoung Lee Akito Sutani Rin Kaneko Jun Takeuchi Tetsuo Sasano Takashi Kohda Kensuke Ihara Kentaro Takahashi Masahiro Yamazoe Tomohiro Morio Tetsushi Furukawa Fumitoshi Ishino
author_sort	Jiyoung Lee
title	In vitro generation of functional murine heart organoids via FGF4 and extracellular matrix
title_short	In vitro generation of functional murine heart organoids via FGF4 and extracellular matrix
title_full	In vitro generation of functional murine heart organoids via FGF4 and extracellular matrix
title_fullStr	In vitro generation of functional murine heart organoids via FGF4 and extracellular matrix
title_full_unstemmed	In vitro generation of functional murine heart organoids via FGF4 and extracellular matrix
title_sort	in vitro generation of functional murine heart organoids via fgf4 and extracellular matrix
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/6e0a5c1a58564f4ca225428e30d3056d
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In vitro generation of functional murine heart organoids via FGF4 and extracellular matrix

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