Disentangling Mitochondria in Alzheimer’s Disease

Alzheimer’s disease (AD) is a major cause of dementia in older adults and is fast becoming a major societal and economic burden due to an increase in life expectancy. Age seems to be the major factor driving AD, and currently, only symptomatic treatments are available. AD has a complex etiology, alt...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autor principal:	Ashu Johri
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Alzheimer’s disease neurodegeneration mitochondria antioxidants PGC-1α sirtuins Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/6e0b2c5337454f8d8e279b517fa090ce
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6e0b2c5337454f8d8e279b517fa090ce
record_format	dspace
spelling	oai:doaj.org-article:6e0b2c5337454f8d8e279b517fa090ce2021-11-11T16:58:50ZDisentangling Mitochondria in Alzheimer’s Disease10.3390/ijms2221115201422-00671661-6596https://doaj.org/article/6e0b2c5337454f8d8e279b517fa090ce2021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11520https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Alzheimer’s disease (AD) is a major cause of dementia in older adults and is fast becoming a major societal and economic burden due to an increase in life expectancy. Age seems to be the major factor driving AD, and currently, only symptomatic treatments are available. AD has a complex etiology, although mitochondrial dysfunction, oxidative stress, inflammation, and metabolic abnormalities have been widely and deeply investigated as plausible mechanisms for its neuropathology. Aβ plaques and hyperphosphorylated tau aggregates, along with cognitive deficits and behavioral problems, are the hallmarks of the disease. Restoration of mitochondrial bioenergetics, prevention of oxidative stress, and diet and exercise seem to be effective in reducing Aβ and in ameliorating learning and memory problems. Many mitochondria-targeted antioxidants have been tested in AD and are currently in development. However, larger streamlined clinical studies are needed to provide hard evidence of benefits in AD. This review discusses the causative factors, as well as potential therapeutics employed in the treatment of AD.Ashu JohriMDPI AGarticleAlzheimer’s diseaseneurodegenerationmitochondriaantioxidantsPGC-1αsirtuinsBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11520, p 11520 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Alzheimer’s disease neurodegeneration mitochondria antioxidants PGC-1α sirtuins Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	Alzheimer’s disease neurodegeneration mitochondria antioxidants PGC-1α sirtuins Biology (General) QH301-705.5 Chemistry QD1-999 Ashu Johri Disentangling Mitochondria in Alzheimer’s Disease
description	Alzheimer’s disease (AD) is a major cause of dementia in older adults and is fast becoming a major societal and economic burden due to an increase in life expectancy. Age seems to be the major factor driving AD, and currently, only symptomatic treatments are available. AD has a complex etiology, although mitochondrial dysfunction, oxidative stress, inflammation, and metabolic abnormalities have been widely and deeply investigated as plausible mechanisms for its neuropathology. Aβ plaques and hyperphosphorylated tau aggregates, along with cognitive deficits and behavioral problems, are the hallmarks of the disease. Restoration of mitochondrial bioenergetics, prevention of oxidative stress, and diet and exercise seem to be effective in reducing Aβ and in ameliorating learning and memory problems. Many mitochondria-targeted antioxidants have been tested in AD and are currently in development. However, larger streamlined clinical studies are needed to provide hard evidence of benefits in AD. This review discusses the causative factors, as well as potential therapeutics employed in the treatment of AD.
format	article
author	Ashu Johri
author_facet	Ashu Johri
author_sort	Ashu Johri
title	Disentangling Mitochondria in Alzheimer’s Disease
title_short	Disentangling Mitochondria in Alzheimer’s Disease
title_full	Disentangling Mitochondria in Alzheimer’s Disease
title_fullStr	Disentangling Mitochondria in Alzheimer’s Disease
title_full_unstemmed	Disentangling Mitochondria in Alzheimer’s Disease
title_sort	disentangling mitochondria in alzheimer’s disease
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6e0b2c5337454f8d8e279b517fa090ce
work_keys_str_mv	AT ashujohri disentanglingmitochondriainalzheimersdisease
_version_	1718432182413819904

Disentangling Mitochondria in Alzheimer’s Disease

Ejemplares similares