mRNA display with library of even-distribution reveals cellular interactors of influenza virus NS1

mRNA display with library of even-distribution reveals cellular interactors of influenza virus NS1

Identification of low abundance proteins interacting with viral proteins can be challenging. Here, Du et al. develop an mRNA display approach with a library of even distribution, identify host proteins interacting with NS1 protein of influenza A virus, and show that one interactor provides a means t...

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Bibliographic Details
Main Authors: Yushen Du, Judd F. Hultquist, Quan Zhou, Anders Olson, Yenwen Tseng, Tian-hao Zhang, Mengying Hong, Kejun Tang, Liubo Chen, Xiangzhi Meng, Michael J. McGregor, Lei Dai, Danyang Gong, Laura Martin-Sancho, Sumit Chanda, Xinming Li, Steve Bensenger, Nevan J. Krogan, Ren Sun
Format: article
Language:EN
Published: Nature Portfolio 2020
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Science
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Online Access:https://doaj.org/article/6e0ba4fb71cb4e7ea04eed81d78d3f6a
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Summary:Identification of low abundance proteins interacting with viral proteins can be challenging. Here, Du et al. develop an mRNA display approach with a library of even distribution, identify host proteins interacting with NS1 protein of influenza A virus, and show that one interactor provides a means to regulate cellular fatty acids synthesis.

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