Tritium labeling of antisense oligonucleotides via different conjugation agents

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Tritium labeling of antisense oligonucleotides via different conjugation agents

Abstract A novel approach to tritium-labeled antisense oligonucleotides (ASO) was established by conjugating N-succinimidyl propionate, as well as maleimide-derivatives, to the 3′-end of ASOs targeting metastasis-associated lung adenocarcinoma transcript 1 (Malat1) containing amino- or sulfhydryl-li...

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Autores principales:	Martin R. Edelmann, Christophe Husser, Martina B. Duschmalé, Guy Fischer, Claudia Senn, Erich Koller, Andreas Brink
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	Antisense oligonucleotide Radiolabeling Malat1 Pharmacokinetics Tritium Therapeutics. Pharmacology RM1-950 Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/6e1253d853d5484ab910488c12140b07
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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