Antiviral activity of mycosynthesized silver nanoparticles against herpes simplex virus and human parainfluenza virus type 3

Swapnil Gaikwad,1 Avinash Ingle,1 Aniket Gade,1 Mahendra Rai,1 Annarita Falanga,3 Novella Incoronato,2 Luigi Russo,2 Stefania Galdiero,3 Massimilano Galdiero2 1Department of Biotechnology, Sant Gadge Baba Amravati University, Amravati, Maharashtra, India; 2Department of Experimental Medicine, Divisi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Gaikwad S, Ingle A, Gade A, Rai M, Falanga A, Incoronato N, Russo L, Galdiero S, Galdiero M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6e12793be37b47d183af2d3291a96543
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6e12793be37b47d183af2d3291a96543
record_format	dspace
spelling	oai:doaj.org-article:6e12793be37b47d183af2d3291a965432021-12-02T05:39:40ZAntiviral activity of mycosynthesized silver nanoparticles against herpes simplex virus and human parainfluenza virus type 31176-91141178-2013https://doaj.org/article/6e12793be37b47d183af2d3291a965432013-11-01T00:00:00Zhttp://www.dovepress.com/antiviral-activity-of-mycosynthesized-silver-nanoparticles-against-her-a14899https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Swapnil Gaikwad,1 Avinash Ingle,1 Aniket Gade,1 Mahendra Rai,1 Annarita Falanga,3 Novella Incoronato,2 Luigi Russo,2 Stefania Galdiero,3 Massimilano Galdiero2 1Department of Biotechnology, Sant Gadge Baba Amravati University, Amravati, Maharashtra, India; 2Department of Experimental Medicine, Division of Microbiology, II University of Naples, 3Department of Pharmacy, University of Naples “Federico II”, DFM and Institute of Biostructures and Bioimages, Naples, Italy Abstract: The interaction between silver nanoparticles and viruses is attracting great interest due to the potential antiviral activity of these particles, and is the subject of much research effort in the treatment of infectious diseases. In this work, we demonstrate that silver nanoparticles undergo a size-dependent interaction with herpes simplex virus types 1 and 2 and with human parainfluenza virus type 3. We show that production of silver nanoparticles from different fungi is feasible, and their antiviral activity is dependent on the production system used. Silver nanoparticles are capable of reducing viral infectivity, probably by blocking interaction of the virus with the cell, which might depend on the size and zeta potential of the silver nanoparticles. Smaller-sized nanoparticles were able to inhibit the infectivity of the viruses analyzed. Keywords: silver nanoparticles, antiviral, herpes simplex virus, parainfluenza virusGaikwad SIngle AGade ARai MFalanga AIncoronato NRusso LGaldiero SGaldiero MDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss Issue 1, Pp 4303-4314 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Gaikwad S Ingle A Gade A Rai M Falanga A Incoronato N Russo L Galdiero S Galdiero M Antiviral activity of mycosynthesized silver nanoparticles against herpes simplex virus and human parainfluenza virus type 3
description	Swapnil Gaikwad,1 Avinash Ingle,1 Aniket Gade,1 Mahendra Rai,1 Annarita Falanga,3 Novella Incoronato,2 Luigi Russo,2 Stefania Galdiero,3 Massimilano Galdiero2 1Department of Biotechnology, Sant Gadge Baba Amravati University, Amravati, Maharashtra, India; 2Department of Experimental Medicine, Division of Microbiology, II University of Naples, 3Department of Pharmacy, University of Naples “Federico II”, DFM and Institute of Biostructures and Bioimages, Naples, Italy Abstract: The interaction between silver nanoparticles and viruses is attracting great interest due to the potential antiviral activity of these particles, and is the subject of much research effort in the treatment of infectious diseases. In this work, we demonstrate that silver nanoparticles undergo a size-dependent interaction with herpes simplex virus types 1 and 2 and with human parainfluenza virus type 3. We show that production of silver nanoparticles from different fungi is feasible, and their antiviral activity is dependent on the production system used. Silver nanoparticles are capable of reducing viral infectivity, probably by blocking interaction of the virus with the cell, which might depend on the size and zeta potential of the silver nanoparticles. Smaller-sized nanoparticles were able to inhibit the infectivity of the viruses analyzed. Keywords: silver nanoparticles, antiviral, herpes simplex virus, parainfluenza virus
format	article
author	Gaikwad S Ingle A Gade A Rai M Falanga A Incoronato N Russo L Galdiero S Galdiero M
author_facet	Gaikwad S Ingle A Gade A Rai M Falanga A Incoronato N Russo L Galdiero S Galdiero M
author_sort	Gaikwad S
title	Antiviral activity of mycosynthesized silver nanoparticles against herpes simplex virus and human parainfluenza virus type 3
title_short	Antiviral activity of mycosynthesized silver nanoparticles against herpes simplex virus and human parainfluenza virus type 3
title_full	Antiviral activity of mycosynthesized silver nanoparticles against herpes simplex virus and human parainfluenza virus type 3
title_fullStr	Antiviral activity of mycosynthesized silver nanoparticles against herpes simplex virus and human parainfluenza virus type 3
title_full_unstemmed	Antiviral activity of mycosynthesized silver nanoparticles against herpes simplex virus and human parainfluenza virus type 3
title_sort	antiviral activity of mycosynthesized silver nanoparticles against herpes simplex virus and human parainfluenza virus type 3
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/6e12793be37b47d183af2d3291a96543
work_keys_str_mv	AT gaikwads antiviralactivityofmycosynthesizedsilvernanoparticlesagainstherpessimplexvirusandhumanparainfluenzavirustype3 AT inglea antiviralactivityofmycosynthesizedsilvernanoparticlesagainstherpessimplexvirusandhumanparainfluenzavirustype3 AT gadea antiviralactivityofmycosynthesizedsilvernanoparticlesagainstherpessimplexvirusandhumanparainfluenzavirustype3 AT raim antiviralactivityofmycosynthesizedsilvernanoparticlesagainstherpessimplexvirusandhumanparainfluenzavirustype3 AT falangaa antiviralactivityofmycosynthesizedsilvernanoparticlesagainstherpessimplexvirusandhumanparainfluenzavirustype3 AT incoronaton antiviralactivityofmycosynthesizedsilvernanoparticlesagainstherpessimplexvirusandhumanparainfluenzavirustype3 AT russol antiviralactivityofmycosynthesizedsilvernanoparticlesagainstherpessimplexvirusandhumanparainfluenzavirustype3 AT galdieros antiviralactivityofmycosynthesizedsilvernanoparticlesagainstherpessimplexvirusandhumanparainfluenzavirustype3 AT galdierom antiviralactivityofmycosynthesizedsilvernanoparticlesagainstherpessimplexvirusandhumanparainfluenzavirustype3
_version_	1718400302677229568

Antiviral activity of mycosynthesized silver nanoparticles against herpes simplex virus and human parainfluenza virus type 3

Ejemplares similares