In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells

The regulation of microtubule (MT) dynamics in cancer cells within the tumor microenvironment is less understood. Here, the authors develop an imaging platform to examine MT dynamics in live xenograft models and show that pro-tumor macrophages modulate MT coherence and alignment to promote cancer ce...

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Autores principales:	Gaurav Luthria, Ran Li, Stephanie Wang, Mark Prytyskach, Rainer H. Kohler, Douglas A. Lauffenburger, Timothy J. Mitchison, Ralph Weissleder, Miles A. Miller
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6e12c582f93443ddbaa1e7221c686a84
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spelling	oai:doaj.org-article:6e12c582f93443ddbaa1e7221c686a842021-12-02T15:33:16ZIn vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells10.1038/s41467-020-17147-y2041-1723https://doaj.org/article/6e12c582f93443ddbaa1e7221c686a842020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17147-yhttps://doaj.org/toc/2041-1723The regulation of microtubule (MT) dynamics in cancer cells within the tumor microenvironment is less understood. Here, the authors develop an imaging platform to examine MT dynamics in live xenograft models and show that pro-tumor macrophages modulate MT coherence and alignment to promote cancer cell migration.Gaurav LuthriaRan LiStephanie WangMark PrytyskachRainer H. KohlerDouglas A. LauffenburgerTimothy J. MitchisonRalph WeisslederMiles A. MillerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gaurav Luthria Ran Li Stephanie Wang Mark Prytyskach Rainer H. Kohler Douglas A. Lauffenburger Timothy J. Mitchison Ralph Weissleder Miles A. Miller In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells
description	The regulation of microtubule (MT) dynamics in cancer cells within the tumor microenvironment is less understood. Here, the authors develop an imaging platform to examine MT dynamics in live xenograft models and show that pro-tumor macrophages modulate MT coherence and alignment to promote cancer cell migration.
format	article
author	Gaurav Luthria Ran Li Stephanie Wang Mark Prytyskach Rainer H. Kohler Douglas A. Lauffenburger Timothy J. Mitchison Ralph Weissleder Miles A. Miller
author_facet	Gaurav Luthria Ran Li Stephanie Wang Mark Prytyskach Rainer H. Kohler Douglas A. Lauffenburger Timothy J. Mitchison Ralph Weissleder Miles A. Miller
author_sort	Gaurav Luthria
title	In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells
title_short	In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells
title_full	In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells
title_fullStr	In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells
title_full_unstemmed	In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells
title_sort	in vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/6e12c582f93443ddbaa1e7221c686a84
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_version_	1718387087428812800

In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells

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