Associations between Global DNA Methylation and Telomere Length in Healthy Adolescents

Abstract Emerging evidence suggests that epigenetics regulates telomere dynamics in adults. However, the relationship between these pathways in children and youth remains unknown. Thus, we examined this association in 542 healthy adolescents aged 14 to 18 years old (44.8% African Americans; 55.2% fe...

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Autores principales:	Yutong Dong, Ying Huang, Bernard Gutin, Anas Raed, Yanbin Dong, Haidong Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6e17185ecd194e38b00ba538a9cd15cc
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spelling	oai:doaj.org-article:6e17185ecd194e38b00ba538a9cd15cc2021-12-02T11:40:44ZAssociations between Global DNA Methylation and Telomere Length in Healthy Adolescents10.1038/s41598-017-04493-z2045-2322https://doaj.org/article/6e17185ecd194e38b00ba538a9cd15cc2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04493-zhttps://doaj.org/toc/2045-2322Abstract Emerging evidence suggests that epigenetics regulates telomere dynamics in adults. However, the relationship between these pathways in children and youth remains unknown. Thus, we examined this association in 542 healthy adolescents aged 14 to 18 years old (44.8% African Americans; 55.2% females). Global DNA methylation level (%5-mC) was quantified using ELISA method. Leukocyte telomere length (LTL) was defined as relative telomere to single copy gene (T/S) ratio. Multiple linear regression models, adjusted for age, gender, ethnicity, Tanner stage, BMI, PA, and batch effect, revealed that %5 mC was associated with LTL (adjusted β = 0.17, p < 0.01). %5 mC accounted for 5.0% of the variation for LTL. A significant gender interaction was identified (p < 0.01). There was an association between %5 mC and LTL in females (all ps < 0.01), but not in males. Further sensitivity analyses by race revealed similar associations in African Americans and whites (all ps < 0.03). The present study, for the first time, shows that lower levels of global DNA methylation are associated with shorter telomere lengths in youth, which may decrease genome stability and augment the susceptibility to diseases. Longitudinal studies are warranted to establish the effects of global DNA methylation on LTL maintenance over time.Yutong DongYing HuangBernard GutinAnas RaedYanbin DongHaidong ZhuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yutong Dong Ying Huang Bernard Gutin Anas Raed Yanbin Dong Haidong Zhu Associations between Global DNA Methylation and Telomere Length in Healthy Adolescents
description	Abstract Emerging evidence suggests that epigenetics regulates telomere dynamics in adults. However, the relationship between these pathways in children and youth remains unknown. Thus, we examined this association in 542 healthy adolescents aged 14 to 18 years old (44.8% African Americans; 55.2% females). Global DNA methylation level (%5-mC) was quantified using ELISA method. Leukocyte telomere length (LTL) was defined as relative telomere to single copy gene (T/S) ratio. Multiple linear regression models, adjusted for age, gender, ethnicity, Tanner stage, BMI, PA, and batch effect, revealed that %5 mC was associated with LTL (adjusted β = 0.17, p < 0.01). %5 mC accounted for 5.0% of the variation for LTL. A significant gender interaction was identified (p < 0.01). There was an association between %5 mC and LTL in females (all ps < 0.01), but not in males. Further sensitivity analyses by race revealed similar associations in African Americans and whites (all ps < 0.03). The present study, for the first time, shows that lower levels of global DNA methylation are associated with shorter telomere lengths in youth, which may decrease genome stability and augment the susceptibility to diseases. Longitudinal studies are warranted to establish the effects of global DNA methylation on LTL maintenance over time.
format	article
author	Yutong Dong Ying Huang Bernard Gutin Anas Raed Yanbin Dong Haidong Zhu
author_facet	Yutong Dong Ying Huang Bernard Gutin Anas Raed Yanbin Dong Haidong Zhu
author_sort	Yutong Dong
title	Associations between Global DNA Methylation and Telomere Length in Healthy Adolescents
title_short	Associations between Global DNA Methylation and Telomere Length in Healthy Adolescents
title_full	Associations between Global DNA Methylation and Telomere Length in Healthy Adolescents
title_fullStr	Associations between Global DNA Methylation and Telomere Length in Healthy Adolescents
title_full_unstemmed	Associations between Global DNA Methylation and Telomere Length in Healthy Adolescents
title_sort	associations between global dna methylation and telomere length in healthy adolescents
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6e17185ecd194e38b00ba538a9cd15cc
work_keys_str_mv	AT yutongdong associationsbetweenglobaldnamethylationandtelomerelengthinhealthyadolescents AT yinghuang associationsbetweenglobaldnamethylationandtelomerelengthinhealthyadolescents AT bernardgutin associationsbetweenglobaldnamethylationandtelomerelengthinhealthyadolescents AT anasraed associationsbetweenglobaldnamethylationandtelomerelengthinhealthyadolescents AT yanbindong associationsbetweenglobaldnamethylationandtelomerelengthinhealthyadolescents AT haidongzhu associationsbetweenglobaldnamethylationandtelomerelengthinhealthyadolescents
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Associations between Global DNA Methylation and Telomere Length in Healthy Adolescents

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