IMMUNOMODULATORY EFFECTS OF BESTIM IN PATIENTS WITH PEPTIC ULCER

Abstract. Ulcer disease is accompanied by all immune responses with the development of secondary immune deficiency. We studied 92 males with peptic ulcer having positive tests for Helicobacter pylori (24 gastric ulcer, mean age 44,7±1,97 and 68 duodenal ulcer, mean age 31,5±1,71). A half of the pati...

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Autores principales:	A. G. Tkacheva, A. I. Dolgushina, K. V. Nikushina, A. S. Simbirtsev
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	bestim immunity т–helpers helicobacter pylori gastric ulcer disease Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/6e1718da8bb94239989ff85adef41004
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spelling	oai:doaj.org-article:6e1718da8bb94239989ff85adef410042021-11-18T08:03:43ZIMMUNOMODULATORY EFFECTS OF BESTIM IN PATIENTS WITH PEPTIC ULCER1563-06252313-741X10.15789/1563-0625-2005-5-6-611-616https://doaj.org/article/6e1718da8bb94239989ff85adef410042014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/653https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Ulcer disease is accompanied by all immune responses with the development of secondary immune deficiency. We studied 92 males with peptic ulcer having positive tests for Helicobacter pylori (24 gastric ulcer, mean age 44,7±1,97 and 68 duodenal ulcer, mean age 31,5±1,71). A half of the patients used only basis antiulcer treatment. 46 patients used bestim in the dose100 mcg per day intramusculare for a 5 days with antisecretory and antihelicobacter drugs. The addition of bestim normalized cellular immunity: count of T-lymphocytes rose from 20,52±0,89% to 31,4±1,16% (p<0,05; confidence interval [CI]: 2,67-11,63). A positive trend in the number of T-lymphocytes was accompanied with increasing of T-helpers from 17,33±0,89% to 24,82±1,11% (p<0,05; 95%CI: 1,72-8,47). In the course of the treatment we observed normalization of monocytes number, an increase of neutrophils activity in blood (p<0,05; 95%CI: 2,35-15,64). We demonstrated decrease in IL-8 production and increase in IFN gamma production. Thus, the application of a new drug Bestim in the combined antiulcer treatment affects the immune state of the patients favourably. It decreases the inflammatory effect in the stomach and duodenal mucosa, it precipitate regress of clinical symptoms and healing of the ulcer.A. G. TkachevaA. I. DolgushinaK. V. NikushinaA. S. SimbirtsevSPb RAACIarticlebestimimmunityт–helpershelicobacter pylorigastric ulcer diseaseImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 7, Iss 5-6, Pp 611-616 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	bestim immunity т–helpers helicobacter pylori gastric ulcer disease Immunologic diseases. Allergy RC581-607
spellingShingle	bestim immunity т–helpers helicobacter pylori gastric ulcer disease Immunologic diseases. Allergy RC581-607 A. G. Tkacheva A. I. Dolgushina K. V. Nikushina A. S. Simbirtsev IMMUNOMODULATORY EFFECTS OF BESTIM IN PATIENTS WITH PEPTIC ULCER
description	Abstract. Ulcer disease is accompanied by all immune responses with the development of secondary immune deficiency. We studied 92 males with peptic ulcer having positive tests for Helicobacter pylori (24 gastric ulcer, mean age 44,7±1,97 and 68 duodenal ulcer, mean age 31,5±1,71). A half of the patients used only basis antiulcer treatment. 46 patients used bestim in the dose100 mcg per day intramusculare for a 5 days with antisecretory and antihelicobacter drugs. The addition of bestim normalized cellular immunity: count of T-lymphocytes rose from 20,52±0,89% to 31,4±1,16% (p<0,05; confidence interval [CI]: 2,67-11,63). A positive trend in the number of T-lymphocytes was accompanied with increasing of T-helpers from 17,33±0,89% to 24,82±1,11% (p<0,05; 95%CI: 1,72-8,47). In the course of the treatment we observed normalization of monocytes number, an increase of neutrophils activity in blood (p<0,05; 95%CI: 2,35-15,64). We demonstrated decrease in IL-8 production and increase in IFN gamma production. Thus, the application of a new drug Bestim in the combined antiulcer treatment affects the immune state of the patients favourably. It decreases the inflammatory effect in the stomach and duodenal mucosa, it precipitate regress of clinical symptoms and healing of the ulcer.
format	article
author	A. G. Tkacheva A. I. Dolgushina K. V. Nikushina A. S. Simbirtsev
author_facet	A. G. Tkacheva A. I. Dolgushina K. V. Nikushina A. S. Simbirtsev
author_sort	A. G. Tkacheva
title	IMMUNOMODULATORY EFFECTS OF BESTIM IN PATIENTS WITH PEPTIC ULCER
title_short	IMMUNOMODULATORY EFFECTS OF BESTIM IN PATIENTS WITH PEPTIC ULCER
title_full	IMMUNOMODULATORY EFFECTS OF BESTIM IN PATIENTS WITH PEPTIC ULCER
title_fullStr	IMMUNOMODULATORY EFFECTS OF BESTIM IN PATIENTS WITH PEPTIC ULCER
title_full_unstemmed	IMMUNOMODULATORY EFFECTS OF BESTIM IN PATIENTS WITH PEPTIC ULCER
title_sort	immunomodulatory effects of bestim in patients with peptic ulcer
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/6e1718da8bb94239989ff85adef41004
work_keys_str_mv	AT agtkacheva immunomodulatoryeffectsofbestiminpatientswithpepticulcer AT aidolgushina immunomodulatoryeffectsofbestiminpatientswithpepticulcer AT kvnikushina immunomodulatoryeffectsofbestiminpatientswithpepticulcer AT assimbirtsev immunomodulatoryeffectsofbestiminpatientswithpepticulcer
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IMMUNOMODULATORY EFFECTS OF BESTIM IN PATIENTS WITH PEPTIC ULCER

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