Prevalence and risk factors of type-2 diabetes mellitus in Ethiopia: systematic review and meta-analysis

Abstract Diabetes mellitus (DM) is a public health problem in developing as well as developed nations. DM leads to many complications that are associated with higher morbidity and mortality worldwide. Therefore, the current study was planned to assess the prevalence and risk factors of type-2 DM in...

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Autores principales:	Melkamu A. Zeru, Endalamaw Tesfa, Aweke A. Mitiku, Awoke Seyoum, Tesfaye Abera Bokoro
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6e17baaeab02450cabdc9e55d6b96327
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spelling	oai:doaj.org-article:6e17baaeab02450cabdc9e55d6b963272021-11-08T10:51:22ZPrevalence and risk factors of type-2 diabetes mellitus in Ethiopia: systematic review and meta-analysis10.1038/s41598-021-01256-92045-2322https://doaj.org/article/6e17baaeab02450cabdc9e55d6b963272021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01256-9https://doaj.org/toc/2045-2322Abstract Diabetes mellitus (DM) is a public health problem in developing as well as developed nations. DM leads to many complications that are associated with higher morbidity and mortality worldwide. Therefore, the current study was planned to assess the prevalence and risk factors of type-2 DM in Ethiopian population. Six electronic databases such as: PubMed, Scopus, Hinari, Web of science, Google Scholar, and African Journals Online were searched for studies published in English up December 30, 2020. Newcastle–Ottawa Scale was used for quality assessment of the included studies. The data was extracted by Microsoft excel and analyzed through Stata version 16 software. The random effect meta-regression analysis was computed at 95% CI to assess the pooled prevalence and risk factors of type-2 DM. Forty observational studies were included in this systematic review and meta-analysis. The pooled prevalence of DM in Ethiopia was 6.5% (95% CI (5.8, 7.3)). The sub-group analysis revealed that the highest prevalence of DM was found in Dire Dawa city administration (14%), and the lowest prevalence was observed in Tigray region (2%). The pooled prevalence of DM was higher (8%) in studies conducted in health facility. Factors like: Age ≥ 40 years ((Adjusted Odds Ratio (AOR): 1.91 (95% CI: 1.05, 3.49)), Illiterate (AOR: 2.74 (95% CI: 1.18, 6.34)), Cigarette smoking (AOR: 1.97 (95% CI: 1.17, 3.32)), Body mass index (BMI) ≥ 25 kg/m2 (AOR: 2.01 (95 CI: 1.46, 2.27)), family history of DM (AOR: 6.14 (95% CI: 2.80, 13.46)), history of hypertension (AOR: 3.00 (95% CI: 1.13, 7.95)) and physical inactivity (AOR: 5.79 (95% CI: 2.12, 15.77)) were significantly associated with type-2 DM in Ethiopian population. In this review, the prevalence of type-2 DM was high. Factors like: Older age, illiteracy, cigarette smoking, MBI ≥ 25, family history of DM, history of hypertension and physical inactivity were an identified risk factors of type-2 DM. Therefore, health education and promotion will be warranted. Further, large scale prospective studies will be recommended to address possible risk factors of type-2 DM in Ethiopian population.Melkamu A. ZeruEndalamaw TesfaAweke A. MitikuAwoke SeyoumTesfaye Abera BokoroNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Melkamu A. Zeru Endalamaw Tesfa Aweke A. Mitiku Awoke Seyoum Tesfaye Abera Bokoro Prevalence and risk factors of type-2 diabetes mellitus in Ethiopia: systematic review and meta-analysis
description	Abstract Diabetes mellitus (DM) is a public health problem in developing as well as developed nations. DM leads to many complications that are associated with higher morbidity and mortality worldwide. Therefore, the current study was planned to assess the prevalence and risk factors of type-2 DM in Ethiopian population. Six electronic databases such as: PubMed, Scopus, Hinari, Web of science, Google Scholar, and African Journals Online were searched for studies published in English up December 30, 2020. Newcastle–Ottawa Scale was used for quality assessment of the included studies. The data was extracted by Microsoft excel and analyzed through Stata version 16 software. The random effect meta-regression analysis was computed at 95% CI to assess the pooled prevalence and risk factors of type-2 DM. Forty observational studies were included in this systematic review and meta-analysis. The pooled prevalence of DM in Ethiopia was 6.5% (95% CI (5.8, 7.3)). The sub-group analysis revealed that the highest prevalence of DM was found in Dire Dawa city administration (14%), and the lowest prevalence was observed in Tigray region (2%). The pooled prevalence of DM was higher (8%) in studies conducted in health facility. Factors like: Age ≥ 40 years ((Adjusted Odds Ratio (AOR): 1.91 (95% CI: 1.05, 3.49)), Illiterate (AOR: 2.74 (95% CI: 1.18, 6.34)), Cigarette smoking (AOR: 1.97 (95% CI: 1.17, 3.32)), Body mass index (BMI) ≥ 25 kg/m2 (AOR: 2.01 (95 CI: 1.46, 2.27)), family history of DM (AOR: 6.14 (95% CI: 2.80, 13.46)), history of hypertension (AOR: 3.00 (95% CI: 1.13, 7.95)) and physical inactivity (AOR: 5.79 (95% CI: 2.12, 15.77)) were significantly associated with type-2 DM in Ethiopian population. In this review, the prevalence of type-2 DM was high. Factors like: Older age, illiteracy, cigarette smoking, MBI ≥ 25, family history of DM, history of hypertension and physical inactivity were an identified risk factors of type-2 DM. Therefore, health education and promotion will be warranted. Further, large scale prospective studies will be recommended to address possible risk factors of type-2 DM in Ethiopian population.
format	article
author	Melkamu A. Zeru Endalamaw Tesfa Aweke A. Mitiku Awoke Seyoum Tesfaye Abera Bokoro
author_facet	Melkamu A. Zeru Endalamaw Tesfa Aweke A. Mitiku Awoke Seyoum Tesfaye Abera Bokoro
author_sort	Melkamu A. Zeru
title	Prevalence and risk factors of type-2 diabetes mellitus in Ethiopia: systematic review and meta-analysis
title_short	Prevalence and risk factors of type-2 diabetes mellitus in Ethiopia: systematic review and meta-analysis
title_full	Prevalence and risk factors of type-2 diabetes mellitus in Ethiopia: systematic review and meta-analysis
title_fullStr	Prevalence and risk factors of type-2 diabetes mellitus in Ethiopia: systematic review and meta-analysis
title_full_unstemmed	Prevalence and risk factors of type-2 diabetes mellitus in Ethiopia: systematic review and meta-analysis
title_sort	prevalence and risk factors of type-2 diabetes mellitus in ethiopia: systematic review and meta-analysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6e17baaeab02450cabdc9e55d6b96327
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Prevalence and risk factors of type-2 diabetes mellitus in Ethiopia: systematic review and meta-analysis

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