A metabolic interplay coordinated by HLX regulates myeloid differentiation and AML through partly overlapping pathways
HLX transcription factor regulates haematopoietic stem and progenitor cell (HSPC) differentiation and is overexpressed in acute myeloid leukemia. Here the authors show that HLX overexpression leads to myeloid differentiation block in zebrafish and human HSPCs by direct regulation of metabolic pathwa...
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Nature Portfolio
2018
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oai:doaj.org-article:6e1870de09fa401dacacea3d50a2697e2021-12-02T14:39:07ZA metabolic interplay coordinated by HLX regulates myeloid differentiation and AML through partly overlapping pathways10.1038/s41467-018-05311-42041-1723https://doaj.org/article/6e1870de09fa401dacacea3d50a2697e2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05311-4https://doaj.org/toc/2041-1723HLX transcription factor regulates haematopoietic stem and progenitor cell (HSPC) differentiation and is overexpressed in acute myeloid leukemia. Here the authors show that HLX overexpression leads to myeloid differentiation block in zebrafish and human HSPCs by direct regulation of metabolic pathways.Indre PiragyteThomas ClapesAikaterini PolyzouRamon I. Klein GeltinkStylianos LefkopoulosNa YinPierre CauchyJonathan D. CurtisLhéanna KlaeyléXavier LangaCora C. A. BeckmannMarcin W. WlodarskiPatrick MüllerDominic Van EssenAngelika RamboldFriedrich G. KappMarina MioneJoerg M. BuescherErika L. PearceAlexander PolyzosEirini TrompoukiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018) |
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DOAJ |
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DOAJ |
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EN |
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Science Q |
| spellingShingle |
Science Q Indre Piragyte Thomas Clapes Aikaterini Polyzou Ramon I. Klein Geltink Stylianos Lefkopoulos Na Yin Pierre Cauchy Jonathan D. Curtis Lhéanna Klaeylé Xavier Langa Cora C. A. Beckmann Marcin W. Wlodarski Patrick Müller Dominic Van Essen Angelika Rambold Friedrich G. Kapp Marina Mione Joerg M. Buescher Erika L. Pearce Alexander Polyzos Eirini Trompouki A metabolic interplay coordinated by HLX regulates myeloid differentiation and AML through partly overlapping pathways |
| description |
HLX transcription factor regulates haematopoietic stem and progenitor cell (HSPC) differentiation and is overexpressed in acute myeloid leukemia. Here the authors show that HLX overexpression leads to myeloid differentiation block in zebrafish and human HSPCs by direct regulation of metabolic pathways. |
| format |
article |
| author |
Indre Piragyte Thomas Clapes Aikaterini Polyzou Ramon I. Klein Geltink Stylianos Lefkopoulos Na Yin Pierre Cauchy Jonathan D. Curtis Lhéanna Klaeylé Xavier Langa Cora C. A. Beckmann Marcin W. Wlodarski Patrick Müller Dominic Van Essen Angelika Rambold Friedrich G. Kapp Marina Mione Joerg M. Buescher Erika L. Pearce Alexander Polyzos Eirini Trompouki |
| author_facet |
Indre Piragyte Thomas Clapes Aikaterini Polyzou Ramon I. Klein Geltink Stylianos Lefkopoulos Na Yin Pierre Cauchy Jonathan D. Curtis Lhéanna Klaeylé Xavier Langa Cora C. A. Beckmann Marcin W. Wlodarski Patrick Müller Dominic Van Essen Angelika Rambold Friedrich G. Kapp Marina Mione Joerg M. Buescher Erika L. Pearce Alexander Polyzos Eirini Trompouki |
| author_sort |
Indre Piragyte |
| title |
A metabolic interplay coordinated by HLX regulates myeloid differentiation and AML through partly overlapping pathways |
| title_short |
A metabolic interplay coordinated by HLX regulates myeloid differentiation and AML through partly overlapping pathways |
| title_full |
A metabolic interplay coordinated by HLX regulates myeloid differentiation and AML through partly overlapping pathways |
| title_fullStr |
A metabolic interplay coordinated by HLX regulates myeloid differentiation and AML through partly overlapping pathways |
| title_full_unstemmed |
A metabolic interplay coordinated by HLX regulates myeloid differentiation and AML through partly overlapping pathways |
| title_sort |
metabolic interplay coordinated by hlx regulates myeloid differentiation and aml through partly overlapping pathways |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/6e1870de09fa401dacacea3d50a2697e |
| work_keys_str_mv |
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