BMP-dependent synaptic development requires Abi-Abl-Rac signaling of BMP receptor macropinocytosis

BMP ligands act as retrograde signalling molecules to regulate presynaptic development, and regulation of BMP receptors by endocytosis may be an important component of this signalling pathway. Here, the authors show that Abi-mediated macropinocytosis of BMP receptors in Drosophila larva and contribu...

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Autores principales:	Najin Kim, Sungdae Kim, Minyeop Nahm, Danielle Kopke, Joohyung Kim, Eunsang Cho, Min-Jung Lee, Mihye Lee, Seung Hyun Kim, Kendal Broadie, Seungbok Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6e18840adca142009f07d07b71d0b53e
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spelling	oai:doaj.org-article:6e18840adca142009f07d07b71d0b53e2021-12-02T17:31:22ZBMP-dependent synaptic development requires Abi-Abl-Rac signaling of BMP receptor macropinocytosis10.1038/s41467-019-08533-22041-1723https://doaj.org/article/6e18840adca142009f07d07b71d0b53e2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08533-2https://doaj.org/toc/2041-1723BMP ligands act as retrograde signalling molecules to regulate presynaptic development, and regulation of BMP receptors by endocytosis may be an important component of this signalling pathway. Here, the authors show that Abi-mediated macropinocytosis of BMP receptors in Drosophila larva and contributes to neuromuscular development.Najin KimSungdae KimMinyeop NahmDanielle KopkeJoohyung KimEunsang ChoMin-Jung LeeMihye LeeSeung Hyun KimKendal BroadieSeungbok LeeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Najin Kim Sungdae Kim Minyeop Nahm Danielle Kopke Joohyung Kim Eunsang Cho Min-Jung Lee Mihye Lee Seung Hyun Kim Kendal Broadie Seungbok Lee BMP-dependent synaptic development requires Abi-Abl-Rac signaling of BMP receptor macropinocytosis
description	BMP ligands act as retrograde signalling molecules to regulate presynaptic development, and regulation of BMP receptors by endocytosis may be an important component of this signalling pathway. Here, the authors show that Abi-mediated macropinocytosis of BMP receptors in Drosophila larva and contributes to neuromuscular development.
format	article
author	Najin Kim Sungdae Kim Minyeop Nahm Danielle Kopke Joohyung Kim Eunsang Cho Min-Jung Lee Mihye Lee Seung Hyun Kim Kendal Broadie Seungbok Lee
author_facet	Najin Kim Sungdae Kim Minyeop Nahm Danielle Kopke Joohyung Kim Eunsang Cho Min-Jung Lee Mihye Lee Seung Hyun Kim Kendal Broadie Seungbok Lee
author_sort	Najin Kim
title	BMP-dependent synaptic development requires Abi-Abl-Rac signaling of BMP receptor macropinocytosis
title_short	BMP-dependent synaptic development requires Abi-Abl-Rac signaling of BMP receptor macropinocytosis
title_full	BMP-dependent synaptic development requires Abi-Abl-Rac signaling of BMP receptor macropinocytosis
title_fullStr	BMP-dependent synaptic development requires Abi-Abl-Rac signaling of BMP receptor macropinocytosis
title_full_unstemmed	BMP-dependent synaptic development requires Abi-Abl-Rac signaling of BMP receptor macropinocytosis
title_sort	bmp-dependent synaptic development requires abi-abl-rac signaling of bmp receptor macropinocytosis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/6e18840adca142009f07d07b71d0b53e
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BMP-dependent synaptic development requires Abi-Abl-Rac signaling of BMP receptor macropinocytosis

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