Single cell transcriptomics reveals lineage trajectory of retinal ganglion cells in wild-type and Atoh7-null retinas
Atoh7 is essential for retinal ganglion cell (RGC) genesis. Here the authors perform scRNAseq on embryonic mouse retina and conclude that Atoh7 defines a transitional state and that other factors also participate in establishing the RGC lineage.
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Nature Portfolio
2021
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oai:doaj.org-article:6e196bf549b6423fb0b29df0f5c27a2e2021-12-02T13:32:57ZSingle cell transcriptomics reveals lineage trajectory of retinal ganglion cells in wild-type and Atoh7-null retinas10.1038/s41467-021-21704-42041-1723https://doaj.org/article/6e196bf549b6423fb0b29df0f5c27a2e2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21704-4https://doaj.org/toc/2041-1723Atoh7 is essential for retinal ganglion cell (RGC) genesis. Here the authors perform scRNAseq on embryonic mouse retina and conclude that Atoh7 defines a transitional state and that other factors also participate in establishing the RGC lineage.Fuguo WuJonathan E. BardJulien KannDonald YergeauDarshan SapkotaYichen GeZihua HuJie WangTao LiuXiuqian MuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-20 (2021) |
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Science Q Fuguo Wu Jonathan E. Bard Julien Kann Donald Yergeau Darshan Sapkota Yichen Ge Zihua Hu Jie Wang Tao Liu Xiuqian Mu Single cell transcriptomics reveals lineage trajectory of retinal ganglion cells in wild-type and Atoh7-null retinas |
description |
Atoh7 is essential for retinal ganglion cell (RGC) genesis. Here the authors perform scRNAseq on embryonic mouse retina and conclude that Atoh7 defines a transitional state and that other factors also participate in establishing the RGC lineage. |
format |
article |
author |
Fuguo Wu Jonathan E. Bard Julien Kann Donald Yergeau Darshan Sapkota Yichen Ge Zihua Hu Jie Wang Tao Liu Xiuqian Mu |
author_facet |
Fuguo Wu Jonathan E. Bard Julien Kann Donald Yergeau Darshan Sapkota Yichen Ge Zihua Hu Jie Wang Tao Liu Xiuqian Mu |
author_sort |
Fuguo Wu |
title |
Single cell transcriptomics reveals lineage trajectory of retinal ganglion cells in wild-type and Atoh7-null retinas |
title_short |
Single cell transcriptomics reveals lineage trajectory of retinal ganglion cells in wild-type and Atoh7-null retinas |
title_full |
Single cell transcriptomics reveals lineage trajectory of retinal ganglion cells in wild-type and Atoh7-null retinas |
title_fullStr |
Single cell transcriptomics reveals lineage trajectory of retinal ganglion cells in wild-type and Atoh7-null retinas |
title_full_unstemmed |
Single cell transcriptomics reveals lineage trajectory of retinal ganglion cells in wild-type and Atoh7-null retinas |
title_sort |
single cell transcriptomics reveals lineage trajectory of retinal ganglion cells in wild-type and atoh7-null retinas |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/6e196bf549b6423fb0b29df0f5c27a2e |
work_keys_str_mv |
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