Single cell transcriptomics reveals lineage trajectory of retinal ganglion cells in wild-type and Atoh7-null retinas

Atoh7 is essential for retinal ganglion cell (RGC) genesis. Here the authors perform scRNAseq on embryonic mouse retina and conclude that Atoh7 defines a transitional state and that other factors also participate in establishing the RGC lineage.

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Autores principales: Fuguo Wu, Jonathan E. Bard, Julien Kann, Donald Yergeau, Darshan Sapkota, Yichen Ge, Zihua Hu, Jie Wang, Tao Liu, Xiuqian Mu
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/6e196bf549b6423fb0b29df0f5c27a2e
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spelling oai:doaj.org-article:6e196bf549b6423fb0b29df0f5c27a2e2021-12-02T13:32:57ZSingle cell transcriptomics reveals lineage trajectory of retinal ganglion cells in wild-type and Atoh7-null retinas10.1038/s41467-021-21704-42041-1723https://doaj.org/article/6e196bf549b6423fb0b29df0f5c27a2e2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21704-4https://doaj.org/toc/2041-1723Atoh7 is essential for retinal ganglion cell (RGC) genesis. Here the authors perform scRNAseq on embryonic mouse retina and conclude that Atoh7 defines a transitional state and that other factors also participate in establishing the RGC lineage.Fuguo WuJonathan E. BardJulien KannDonald YergeauDarshan SapkotaYichen GeZihua HuJie WangTao LiuXiuqian MuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Fuguo Wu
Jonathan E. Bard
Julien Kann
Donald Yergeau
Darshan Sapkota
Yichen Ge
Zihua Hu
Jie Wang
Tao Liu
Xiuqian Mu
Single cell transcriptomics reveals lineage trajectory of retinal ganglion cells in wild-type and Atoh7-null retinas
description Atoh7 is essential for retinal ganglion cell (RGC) genesis. Here the authors perform scRNAseq on embryonic mouse retina and conclude that Atoh7 defines a transitional state and that other factors also participate in establishing the RGC lineage.
format article
author Fuguo Wu
Jonathan E. Bard
Julien Kann
Donald Yergeau
Darshan Sapkota
Yichen Ge
Zihua Hu
Jie Wang
Tao Liu
Xiuqian Mu
author_facet Fuguo Wu
Jonathan E. Bard
Julien Kann
Donald Yergeau
Darshan Sapkota
Yichen Ge
Zihua Hu
Jie Wang
Tao Liu
Xiuqian Mu
author_sort Fuguo Wu
title Single cell transcriptomics reveals lineage trajectory of retinal ganglion cells in wild-type and Atoh7-null retinas
title_short Single cell transcriptomics reveals lineage trajectory of retinal ganglion cells in wild-type and Atoh7-null retinas
title_full Single cell transcriptomics reveals lineage trajectory of retinal ganglion cells in wild-type and Atoh7-null retinas
title_fullStr Single cell transcriptomics reveals lineage trajectory of retinal ganglion cells in wild-type and Atoh7-null retinas
title_full_unstemmed Single cell transcriptomics reveals lineage trajectory of retinal ganglion cells in wild-type and Atoh7-null retinas
title_sort single cell transcriptomics reveals lineage trajectory of retinal ganglion cells in wild-type and atoh7-null retinas
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/6e196bf549b6423fb0b29df0f5c27a2e
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