A detailed observational study of maternal and neonatal variables affecting the thyroid-stimulating hormone levels in neonates

Abstract Background Thyroid hormones are essential for fetal growth and the central nervous system development. Thyroid-stimulating hormone (TSH) is the key regulatory hormone. Their levels are quite dynamic in the perinatal period and are influenced by multiple factors. These factors should be take...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	N. R. Verma, G. Naik, S. Patel, P. Padhi, T. Naik, R. Nanda
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	nTSH Newborn screening Regression analysis Maternal Neonatal factors Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/6e1eed1893b54c83a5b4bb14182c5e74
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6e1eed1893b54c83a5b4bb14182c5e74
record_format	dspace
spelling	oai:doaj.org-article:6e1eed1893b54c83a5b4bb14182c5e742021-11-14T12:39:01ZA detailed observational study of maternal and neonatal variables affecting the thyroid-stimulating hormone levels in neonates10.1186/s43054-021-00080-02090-9942https://doaj.org/article/6e1eed1893b54c83a5b4bb14182c5e742021-11-01T00:00:00Zhttps://doi.org/10.1186/s43054-021-00080-0https://doaj.org/toc/2090-9942Abstract Background Thyroid hormones are essential for fetal growth and the central nervous system development. Thyroid-stimulating hormone (TSH) is the key regulatory hormone. Their levels are quite dynamic in the perinatal period and are influenced by multiple factors. These factors should be taken into consideration during newborn screening. This study aimed to observe the impact of maternal and neonatal factors on neonatal TSH status. Results Neonatal TSH (nTSH) depicted a positive correlation with parity (p = 0.066) while negative correlation recorded with maternal blood haemoglobin (p = 0.007) among maternal factors. New-born length (p = 0.027) and birth weight (p < 0.001) exhibited a negative correlation with nTSH among neonatal factors. Conclusions This study concludes that among all the maternal and neonatal factors, birth weight shows the most influence on nTSH. However, the effect may be compounded by other factors. As these risk elements rarely occur singly, it is often difficult to find the exposure which confer the risk on children. These factors should be considered while interpreting the result of the screening program.N. R. VermaG. NaikS. PatelP. PadhiT. NaikR. NandaSpringerOpenarticlenTSHNewborn screeningRegression analysisMaternalNeonatal factorsPediatricsRJ1-570ENEgyptian Pediatric Association Gazette, Vol 69, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	nTSH Newborn screening Regression analysis Maternal Neonatal factors Pediatrics RJ1-570
spellingShingle	nTSH Newborn screening Regression analysis Maternal Neonatal factors Pediatrics RJ1-570 N. R. Verma G. Naik S. Patel P. Padhi T. Naik R. Nanda A detailed observational study of maternal and neonatal variables affecting the thyroid-stimulating hormone levels in neonates
description	Abstract Background Thyroid hormones are essential for fetal growth and the central nervous system development. Thyroid-stimulating hormone (TSH) is the key regulatory hormone. Their levels are quite dynamic in the perinatal period and are influenced by multiple factors. These factors should be taken into consideration during newborn screening. This study aimed to observe the impact of maternal and neonatal factors on neonatal TSH status. Results Neonatal TSH (nTSH) depicted a positive correlation with parity (p = 0.066) while negative correlation recorded with maternal blood haemoglobin (p = 0.007) among maternal factors. New-born length (p = 0.027) and birth weight (p < 0.001) exhibited a negative correlation with nTSH among neonatal factors. Conclusions This study concludes that among all the maternal and neonatal factors, birth weight shows the most influence on nTSH. However, the effect may be compounded by other factors. As these risk elements rarely occur singly, it is often difficult to find the exposure which confer the risk on children. These factors should be considered while interpreting the result of the screening program.
format	article
author	N. R. Verma G. Naik S. Patel P. Padhi T. Naik R. Nanda
author_facet	N. R. Verma G. Naik S. Patel P. Padhi T. Naik R. Nanda
author_sort	N. R. Verma
title	A detailed observational study of maternal and neonatal variables affecting the thyroid-stimulating hormone levels in neonates
title_short	A detailed observational study of maternal and neonatal variables affecting the thyroid-stimulating hormone levels in neonates
title_full	A detailed observational study of maternal and neonatal variables affecting the thyroid-stimulating hormone levels in neonates
title_fullStr	A detailed observational study of maternal and neonatal variables affecting the thyroid-stimulating hormone levels in neonates
title_full_unstemmed	A detailed observational study of maternal and neonatal variables affecting the thyroid-stimulating hormone levels in neonates
title_sort	detailed observational study of maternal and neonatal variables affecting the thyroid-stimulating hormone levels in neonates
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/6e1eed1893b54c83a5b4bb14182c5e74
work_keys_str_mv	AT nrverma adetailedobservationalstudyofmaternalandneonatalvariablesaffectingthethyroidstimulatinghormonelevelsinneonates AT gnaik adetailedobservationalstudyofmaternalandneonatalvariablesaffectingthethyroidstimulatinghormonelevelsinneonates AT spatel adetailedobservationalstudyofmaternalandneonatalvariablesaffectingthethyroidstimulatinghormonelevelsinneonates AT ppadhi adetailedobservationalstudyofmaternalandneonatalvariablesaffectingthethyroidstimulatinghormonelevelsinneonates AT tnaik adetailedobservationalstudyofmaternalandneonatalvariablesaffectingthethyroidstimulatinghormonelevelsinneonates AT rnanda adetailedobservationalstudyofmaternalandneonatalvariablesaffectingthethyroidstimulatinghormonelevelsinneonates AT nrverma detailedobservationalstudyofmaternalandneonatalvariablesaffectingthethyroidstimulatinghormonelevelsinneonates AT gnaik detailedobservationalstudyofmaternalandneonatalvariablesaffectingthethyroidstimulatinghormonelevelsinneonates AT spatel detailedobservationalstudyofmaternalandneonatalvariablesaffectingthethyroidstimulatinghormonelevelsinneonates AT ppadhi detailedobservationalstudyofmaternalandneonatalvariablesaffectingthethyroidstimulatinghormonelevelsinneonates AT tnaik detailedobservationalstudyofmaternalandneonatalvariablesaffectingthethyroidstimulatinghormonelevelsinneonates AT rnanda detailedobservationalstudyofmaternalandneonatalvariablesaffectingthethyroidstimulatinghormonelevelsinneonates
_version_	1718429111820484608

A detailed observational study of maternal and neonatal variables affecting the thyroid-stimulating hormone levels in neonates

Ejemplares similares