Genome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease

Non-alcoholic fatty liver disease (NAFLD) is a risk factor for other types of liver diseases. Here, the authors integrate transcriptomic and metabolomic data from patients with NAFLD with a genome-scale metabolic model to paint a comprehensive picture of liver function in NAFLD.

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Detalles Bibliográficos
Autores principales: Tuulia Hyötyläinen, Livnat Jerby, Elina M. Petäjä, Ismo Mattila, Sirkku Jäntti, Petri Auvinen, Amalia Gastaldelli, Hannele Yki-Järvinen, Eytan Ruppin, Matej Orešič
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/6e1fc59352494a63bee5cc567082d455
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Descripción
Sumario:Non-alcoholic fatty liver disease (NAFLD) is a risk factor for other types of liver diseases. Here, the authors integrate transcriptomic and metabolomic data from patients with NAFLD with a genome-scale metabolic model to paint a comprehensive picture of liver function in NAFLD.