Genome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease

Genome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease

Non-alcoholic fatty liver disease (NAFLD) is a risk factor for other types of liver diseases. Here, the authors integrate transcriptomic and metabolomic data from patients with NAFLD with a genome-scale metabolic model to paint a comprehensive picture of liver function in NAFLD.

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Autores principales: Tuulia Hyötyläinen, Livnat Jerby, Elina M. Petäjä, Ismo Mattila, Sirkku Jäntti, Petri Auvinen, Amalia Gastaldelli, Hannele Yki-Järvinen, Eytan Ruppin, Matej Orešič
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/6e1fc59352494a63bee5cc567082d455
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spelling oai:doaj.org-article:6e1fc59352494a63bee5cc567082d4552021-12-02T14:38:57ZGenome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease10.1038/ncomms99942041-1723https://doaj.org/article/6e1fc59352494a63bee5cc567082d4552016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms9994https://doaj.org/toc/2041-1723Non-alcoholic fatty liver disease (NAFLD) is a risk factor for other types of liver diseases. Here, the authors integrate transcriptomic and metabolomic data from patients with NAFLD with a genome-scale metabolic model to paint a comprehensive picture of liver function in NAFLD.Tuulia HyötyläinenLivnat JerbyElina M. PetäjäIsmo MattilaSirkku JänttiPetri AuvinenAmalia GastaldelliHannele Yki-JärvinenEytan RuppinMatej OrešičNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Tuulia Hyötyläinen
Livnat Jerby
Elina M. Petäjä
Ismo Mattila
Sirkku Jäntti
Petri Auvinen
Amalia Gastaldelli
Hannele Yki-Järvinen
Eytan Ruppin
Matej Orešič
Genome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease
description Non-alcoholic fatty liver disease (NAFLD) is a risk factor for other types of liver diseases. Here, the authors integrate transcriptomic and metabolomic data from patients with NAFLD with a genome-scale metabolic model to paint a comprehensive picture of liver function in NAFLD.
format article
author Tuulia Hyötyläinen
Livnat Jerby
Elina M. Petäjä
Ismo Mattila
Sirkku Jäntti
Petri Auvinen
Amalia Gastaldelli
Hannele Yki-Järvinen
Eytan Ruppin
Matej Orešič
author_facet Tuulia Hyötyläinen
Livnat Jerby
Elina M. Petäjä
Ismo Mattila
Sirkku Jäntti
Petri Auvinen
Amalia Gastaldelli
Hannele Yki-Järvinen
Eytan Ruppin
Matej Orešič
author_sort Tuulia Hyötyläinen
title Genome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease
title_short Genome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease
title_full Genome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease
title_fullStr Genome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease
title_full_unstemmed Genome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease
title_sort genome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/6e1fc59352494a63bee5cc567082d455
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AT livnatjerby genomescalestudyrevealsreducedmetabolicadaptabilityinpatientswithnonalcoholicfattyliverdisease
AT elinampetaja genomescalestudyrevealsreducedmetabolicadaptabilityinpatientswithnonalcoholicfattyliverdisease
AT ismomattila genomescalestudyrevealsreducedmetabolicadaptabilityinpatientswithnonalcoholicfattyliverdisease
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AT hanneleykijarvinen genomescalestudyrevealsreducedmetabolicadaptabilityinpatientswithnonalcoholicfattyliverdisease
AT eytanruppin genomescalestudyrevealsreducedmetabolicadaptabilityinpatientswithnonalcoholicfattyliverdisease
AT matejoresic genomescalestudyrevealsreducedmetabolicadaptabilityinpatientswithnonalcoholicfattyliverdisease
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