IR780-loaded folate-targeted nanoparticles for near-infrared fluorescence image-guided surgery and photothermal therapy in ovarian cancer

Jiao Song,1,2 Ni Zhang,1,2 Liang Zhang,2,3 Hengjing Yi,2 Yi Liu,1,2 Yanxi Li,1 Xuelin Li,2,4 Meng Wu,2,5 Lan Hao,2,3 Zhu Yang,1 Zhigang Wang2,31Gynaecology and Obstetrics Department, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, People’s Republic of Chin...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Song J, Zhang N, Zhang L, Yi H, Liu Y, Li Y, Li X, Wu M, Hao L, Yang Z, Wang Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Ovarian cancer Imaged-guide surgery IR780 iodide Photothermal therapy Nanomedicine Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6e20094068c046fb82627bb01e93dd4c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6e20094068c046fb82627bb01e93dd4c
record_format	dspace
spelling	oai:doaj.org-article:6e20094068c046fb82627bb01e93dd4c2021-12-02T04:33:55ZIR780-loaded folate-targeted nanoparticles for near-infrared fluorescence image-guided surgery and photothermal therapy in ovarian cancer1178-2013https://doaj.org/article/6e20094068c046fb82627bb01e93dd4c2019-04-01T00:00:00Zhttps://www.dovepress.com/ir780-loaded-folate-targeted-nanoparticles-for-near-infrared-fluoresce-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Jiao Song,1,2 Ni Zhang,1,2 Liang Zhang,2,3 Hengjing Yi,2 Yi Liu,1,2 Yanxi Li,1 Xuelin Li,2,4 Meng Wu,2,5 Lan Hao,2,3 Zhu Yang,1 Zhigang Wang2,31Gynaecology and Obstetrics Department, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, People’s Republic of China; 2Chongqing Key Laboratory of Ultrasound Molecular Imaging, Chongqing Medical University, Chongqing 400010, People’s Republic of China; 3Ultrasound Department, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, People’s Republic of China; 4Geriatric Department, Chongqing General Hospital, Chongqing 400014, People’s Republic of China; 5Ultrasound Department, Zhongnan Hospital of Wuhan University, Hubei 430071, People’s Republic of ChinaBackground and purpose: Surgery is regarded as the gold standard for patients with advanced ovarian cancer. However, complete surgical removal of tumors remains extremely challenging; fewer than 40% of patients are cured. Here, we developed a new modality of theranostics for ovarian cancer based on a near-infrared light-triggered nanoparticle.Methods: Nanoparticles loading IR780 iodide on base of folate modified liposomes were prepared and used for theranostics of ovarian cancer. Tumor targeting of FA-IR780-NP was evaluated in vitro and in an ovarian xenograft tumor model. A fluorescence stereomicroscope was applied to evaluate the tumor recognition of FA-IR780-NP during surgery. FA-IR780-NP mediated photothermal therapy effect was compared with other treatments in vivo.Results: FA-IR780-NP was demonstrated to specifically accumulate in tumors. IR780 iodide selectively accumulated in tumors; the enhanced permeability and retention effect of the nanoparticles and the active targeting of folate contributed to the excellent tumor targeting of FA-IR780-NP. With the aid of tumor targeting, FA-IR780-NP could be used as an indicator for the real-time delineation of tumor margins during surgery. Furthermore, photothermal therapy mediated by FA-IR780-NP effectively eradicated ovarian cancer tumors compared with other groups.Conclusion: In this study, we present a potential, effective approach for ovarian cancer treatment through near-infrared fluorescence image-guided resection and photothermal therapy to eliminate malignant tissue.Keywords: ovarian cancer, imaged-guide surgery, IR780 iodide, photothermal therapy, nanomedicineSong JZhang NZhang LYi HLiu YLi YLi XWu MHao LYang ZWang ZDove Medical PressarticleOvarian cancerImaged-guide surgeryIR780 iodidePhotothermal therapyNanomedicineMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 2757-2772 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ovarian cancer Imaged-guide surgery IR780 iodide Photothermal therapy Nanomedicine Medicine (General) R5-920
spellingShingle	Ovarian cancer Imaged-guide surgery IR780 iodide Photothermal therapy Nanomedicine Medicine (General) R5-920 Song J Zhang N Zhang L Yi H Liu Y Li Y Li X Wu M Hao L Yang Z Wang Z IR780-loaded folate-targeted nanoparticles for near-infrared fluorescence image-guided surgery and photothermal therapy in ovarian cancer
description	Jiao Song,1,2 Ni Zhang,1,2 Liang Zhang,2,3 Hengjing Yi,2 Yi Liu,1,2 Yanxi Li,1 Xuelin Li,2,4 Meng Wu,2,5 Lan Hao,2,3 Zhu Yang,1 Zhigang Wang2,31Gynaecology and Obstetrics Department, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, People’s Republic of China; 2Chongqing Key Laboratory of Ultrasound Molecular Imaging, Chongqing Medical University, Chongqing 400010, People’s Republic of China; 3Ultrasound Department, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, People’s Republic of China; 4Geriatric Department, Chongqing General Hospital, Chongqing 400014, People’s Republic of China; 5Ultrasound Department, Zhongnan Hospital of Wuhan University, Hubei 430071, People’s Republic of ChinaBackground and purpose: Surgery is regarded as the gold standard for patients with advanced ovarian cancer. However, complete surgical removal of tumors remains extremely challenging; fewer than 40% of patients are cured. Here, we developed a new modality of theranostics for ovarian cancer based on a near-infrared light-triggered nanoparticle.Methods: Nanoparticles loading IR780 iodide on base of folate modified liposomes were prepared and used for theranostics of ovarian cancer. Tumor targeting of FA-IR780-NP was evaluated in vitro and in an ovarian xenograft tumor model. A fluorescence stereomicroscope was applied to evaluate the tumor recognition of FA-IR780-NP during surgery. FA-IR780-NP mediated photothermal therapy effect was compared with other treatments in vivo.Results: FA-IR780-NP was demonstrated to specifically accumulate in tumors. IR780 iodide selectively accumulated in tumors; the enhanced permeability and retention effect of the nanoparticles and the active targeting of folate contributed to the excellent tumor targeting of FA-IR780-NP. With the aid of tumor targeting, FA-IR780-NP could be used as an indicator for the real-time delineation of tumor margins during surgery. Furthermore, photothermal therapy mediated by FA-IR780-NP effectively eradicated ovarian cancer tumors compared with other groups.Conclusion: In this study, we present a potential, effective approach for ovarian cancer treatment through near-infrared fluorescence image-guided resection and photothermal therapy to eliminate malignant tissue.Keywords: ovarian cancer, imaged-guide surgery, IR780 iodide, photothermal therapy, nanomedicine
format	article
author	Song J Zhang N Zhang L Yi H Liu Y Li Y Li X Wu M Hao L Yang Z Wang Z
author_facet	Song J Zhang N Zhang L Yi H Liu Y Li Y Li X Wu M Hao L Yang Z Wang Z
author_sort	Song J
title	IR780-loaded folate-targeted nanoparticles for near-infrared fluorescence image-guided surgery and photothermal therapy in ovarian cancer
title_short	IR780-loaded folate-targeted nanoparticles for near-infrared fluorescence image-guided surgery and photothermal therapy in ovarian cancer
title_full	IR780-loaded folate-targeted nanoparticles for near-infrared fluorescence image-guided surgery and photothermal therapy in ovarian cancer
title_fullStr	IR780-loaded folate-targeted nanoparticles for near-infrared fluorescence image-guided surgery and photothermal therapy in ovarian cancer
title_full_unstemmed	IR780-loaded folate-targeted nanoparticles for near-infrared fluorescence image-guided surgery and photothermal therapy in ovarian cancer
title_sort	ir780-loaded folate-targeted nanoparticles for near-infrared fluorescence image-guided surgery and photothermal therapy in ovarian cancer
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/6e20094068c046fb82627bb01e93dd4c
work_keys_str_mv	AT songj ir780loadedfolatetargetednanoparticlesfornearinfraredfluorescenceimageguidedsurgeryandphotothermaltherapyinovariancancer AT zhangn ir780loadedfolatetargetednanoparticlesfornearinfraredfluorescenceimageguidedsurgeryandphotothermaltherapyinovariancancer AT zhangl ir780loadedfolatetargetednanoparticlesfornearinfraredfluorescenceimageguidedsurgeryandphotothermaltherapyinovariancancer AT yih ir780loadedfolatetargetednanoparticlesfornearinfraredfluorescenceimageguidedsurgeryandphotothermaltherapyinovariancancer AT liuy ir780loadedfolatetargetednanoparticlesfornearinfraredfluorescenceimageguidedsurgeryandphotothermaltherapyinovariancancer AT liy ir780loadedfolatetargetednanoparticlesfornearinfraredfluorescenceimageguidedsurgeryandphotothermaltherapyinovariancancer AT lix ir780loadedfolatetargetednanoparticlesfornearinfraredfluorescenceimageguidedsurgeryandphotothermaltherapyinovariancancer AT wum ir780loadedfolatetargetednanoparticlesfornearinfraredfluorescenceimageguidedsurgeryandphotothermaltherapyinovariancancer AT haol ir780loadedfolatetargetednanoparticlesfornearinfraredfluorescenceimageguidedsurgeryandphotothermaltherapyinovariancancer AT yangz ir780loadedfolatetargetednanoparticlesfornearinfraredfluorescenceimageguidedsurgeryandphotothermaltherapyinovariancancer AT wangz ir780loadedfolatetargetednanoparticlesfornearinfraredfluorescenceimageguidedsurgeryandphotothermaltherapyinovariancancer
_version_	1718401125033443328

IR780-loaded folate-targeted nanoparticles for near-infrared fluorescence image-guided surgery and photothermal therapy in ovarian cancer

Ejemplares similares