Male sex is not an independent risk factor for recurrence of differentiated thyroid cancer: a propensity score-matching study

Abstract Male patients have a significantly higher prevalence of advanced-stage thyroid cancer. However, sex differences in the risk of differentiated thyroid carcinoma (DTC) recurrence have not been fully elucidated. Therefore, the present study aimed to investigate male sex as a prognostic factor...

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Autores principales:	Joonseon Park, Kwangsoon Kim, Dong-Jun Lim, Ja Seong Bae, Jeong Soo Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6e2086bac71f4126a7809bceee5c5844
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spelling	oai:doaj.org-article:6e2086bac71f4126a7809bceee5c58442021-12-02T17:55:13ZMale sex is not an independent risk factor for recurrence of differentiated thyroid cancer: a propensity score-matching study10.1038/s41598-021-94461-52045-2322https://doaj.org/article/6e2086bac71f4126a7809bceee5c58442021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94461-5https://doaj.org/toc/2045-2322Abstract Male patients have a significantly higher prevalence of advanced-stage thyroid cancer. However, sex differences in the risk of differentiated thyroid carcinoma (DTC) recurrence have not been fully elucidated. Therefore, the present study aimed to investigate male sex as a prognostic factor for DTC. We assessed 5566 patients with DTC who underwent thyroid surgery between January 2009 and December 2015 at Seoul St. Mary’s Hospital (Seoul, Korea). Clinicopathological characteristics and long-term oncologic outcomes between female and male patients with DTC were compared using propensity score matching to reduce selection bias. The mean follow-up duration was 99.9 ± 18.7 months. The recurrence rate was significantly higher in male patients than female patients before matching (3.3% vs. 2.2%, p = 0.030), and there was no significant difference in recurrence rates between the matched groups after matching (3.0% vs. 2.5%, p = 0.591). Based on Kaplan–Meier analysis, the two groups did not significantly differ in disease-free survival after matching. Multivariate analysis revealed that male sex was not an independent prognostic factor of DTC recurrence. Male sex did not have a significant effect on DTC recurrence. Further studies with larger cohorts are required to validate the findings of this study.Joonseon ParkKwangsoon KimDong-Jun LimJa Seong BaeJeong Soo KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Joonseon Park Kwangsoon Kim Dong-Jun Lim Ja Seong Bae Jeong Soo Kim Male sex is not an independent risk factor for recurrence of differentiated thyroid cancer: a propensity score-matching study
description	Abstract Male patients have a significantly higher prevalence of advanced-stage thyroid cancer. However, sex differences in the risk of differentiated thyroid carcinoma (DTC) recurrence have not been fully elucidated. Therefore, the present study aimed to investigate male sex as a prognostic factor for DTC. We assessed 5566 patients with DTC who underwent thyroid surgery between January 2009 and December 2015 at Seoul St. Mary’s Hospital (Seoul, Korea). Clinicopathological characteristics and long-term oncologic outcomes between female and male patients with DTC were compared using propensity score matching to reduce selection bias. The mean follow-up duration was 99.9 ± 18.7 months. The recurrence rate was significantly higher in male patients than female patients before matching (3.3% vs. 2.2%, p = 0.030), and there was no significant difference in recurrence rates between the matched groups after matching (3.0% vs. 2.5%, p = 0.591). Based on Kaplan–Meier analysis, the two groups did not significantly differ in disease-free survival after matching. Multivariate analysis revealed that male sex was not an independent prognostic factor of DTC recurrence. Male sex did not have a significant effect on DTC recurrence. Further studies with larger cohorts are required to validate the findings of this study.
format	article
author	Joonseon Park Kwangsoon Kim Dong-Jun Lim Ja Seong Bae Jeong Soo Kim
author_facet	Joonseon Park Kwangsoon Kim Dong-Jun Lim Ja Seong Bae Jeong Soo Kim
author_sort	Joonseon Park
title	Male sex is not an independent risk factor for recurrence of differentiated thyroid cancer: a propensity score-matching study
title_short	Male sex is not an independent risk factor for recurrence of differentiated thyroid cancer: a propensity score-matching study
title_full	Male sex is not an independent risk factor for recurrence of differentiated thyroid cancer: a propensity score-matching study
title_fullStr	Male sex is not an independent risk factor for recurrence of differentiated thyroid cancer: a propensity score-matching study
title_full_unstemmed	Male sex is not an independent risk factor for recurrence of differentiated thyroid cancer: a propensity score-matching study
title_sort	male sex is not an independent risk factor for recurrence of differentiated thyroid cancer: a propensity score-matching study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6e2086bac71f4126a7809bceee5c5844
work_keys_str_mv	AT joonseonpark malesexisnotanindependentriskfactorforrecurrenceofdifferentiatedthyroidcancerapropensityscorematchingstudy AT kwangsoonkim malesexisnotanindependentriskfactorforrecurrenceofdifferentiatedthyroidcancerapropensityscorematchingstudy AT dongjunlim malesexisnotanindependentriskfactorforrecurrenceofdifferentiatedthyroidcancerapropensityscorematchingstudy AT jaseongbae malesexisnotanindependentriskfactorforrecurrenceofdifferentiatedthyroidcancerapropensityscorematchingstudy AT jeongsookim malesexisnotanindependentriskfactorforrecurrenceofdifferentiatedthyroidcancerapropensityscorematchingstudy
_version_	1718379113210707968

Male sex is not an independent risk factor for recurrence of differentiated thyroid cancer: a propensity score-matching study

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