A Review: Matrix Metallopeptidase-9 Nanoparticles Targeted for the Treatment of Diabetic Foot Ulcers

Wakuma Wakene Jifar,1 Seyfe Asrade Atnafie,2 Sundaramoorthy Angalaparameswari1 1Mettu University, College of Health Sciences, Department of Pharmacy, Mettu, Ethiopia; 2University of Gondar, College of Medicine and Health Sciences, School of Pharmacy, Department of Pharmacology, Gondar, EthiopiaCorre...

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Autores principales:	Jifar WW, Atnafie SA, Angalaparameswari S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	diabetic foot ulcer gangrene probiotics antimicrobial peptide Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6e22d687e42948de955f5b482ed88dc3
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spelling	oai:doaj.org-article:6e22d687e42948de955f5b482ed88dc32021-11-30T18:50:37ZA Review: Matrix Metallopeptidase-9 Nanoparticles Targeted for the Treatment of Diabetic Foot Ulcers1178-2390https://doaj.org/article/6e22d687e42948de955f5b482ed88dc32021-12-01T00:00:00Zhttps://www.dovepress.com/a-review-matrix-metallopeptidase-9-nanoparticles-targeted-for-the-trea-peer-reviewed-fulltext-article-JMDHhttps://doaj.org/toc/1178-2390Wakuma Wakene Jifar,1 Seyfe Asrade Atnafie,2 Sundaramoorthy Angalaparameswari1 1Mettu University, College of Health Sciences, Department of Pharmacy, Mettu, Ethiopia; 2University of Gondar, College of Medicine and Health Sciences, School of Pharmacy, Department of Pharmacology, Gondar, EthiopiaCorrespondence: Wakuma Wakene JifarDepartment of Pharmacy, College of Health Sciences, Mettu University, P.O. Box: 318, Mettu, EthiopiaTel +251963421238Email wakewakish05@gmail.comAbstract: Diabetes foot ulcers are a leading cause of death in diabetic individuals. There are very few medicines and treatments that have received regulatory clearance for this indication, and numerous compounds from various pharmacological classes are now in various stages of clinical studies for diabetic foot ulcers treatment. Multiple risk factors contribute to diabetic foot ulcers, including neuropathy, peripheral artery disease, infection, gender, cigarette smoking, and age. The present difficulties in diabetic foot ulcers treatment are related to bacterial resistance to currently utilized antibiotics. Inhibition of the quorum sensing (QS) system and targeting matrix metallopeptidase-9 (MMP-9) are promising. This study focuses on the difficulties of existing treatment, current treatment technique, and novel pharmacological targets for diabetic foot ulcer. The electronic data base search diabetic for literature on foot ulcers treatment was carried out using Science Direct, PubMed, Google-Scholar, Springer Link, Scopus, and Wiley up to 2021. Becaplermin, a medication that targets MMP-9, glyceryl trinitrate, which inhibits the bacterial quorum sensing system, probiotic therapy, and nano technological solutions are just a few of the novel pharmaceuticals being developed for diabetic foot ulcers treatment. A combination of therapies, rather than one particular agent, will be the best option for treatment of Diabetes foot ulcer since it is multifactorial factors that render occurs of diabetic foot ulcer.Keywords: diabetic foot ulcer, gangrene, probiotics, antimicrobial peptideJifar WWAtnafie SAAngalaparameswari SDove Medical Pressarticlediabetic foot ulcergangreneprobioticsantimicrobial peptideMedicine (General)R5-920ENJournal of Multidisciplinary Healthcare, Vol Volume 14, Pp 3321-3329 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetic foot ulcer gangrene probiotics antimicrobial peptide Medicine (General) R5-920
spellingShingle	diabetic foot ulcer gangrene probiotics antimicrobial peptide Medicine (General) R5-920 Jifar WW Atnafie SA Angalaparameswari S A Review: Matrix Metallopeptidase-9 Nanoparticles Targeted for the Treatment of Diabetic Foot Ulcers
description	Wakuma Wakene Jifar,1 Seyfe Asrade Atnafie,2 Sundaramoorthy Angalaparameswari1 1Mettu University, College of Health Sciences, Department of Pharmacy, Mettu, Ethiopia; 2University of Gondar, College of Medicine and Health Sciences, School of Pharmacy, Department of Pharmacology, Gondar, EthiopiaCorrespondence: Wakuma Wakene JifarDepartment of Pharmacy, College of Health Sciences, Mettu University, P.O. Box: 318, Mettu, EthiopiaTel +251963421238Email wakewakish05@gmail.comAbstract: Diabetes foot ulcers are a leading cause of death in diabetic individuals. There are very few medicines and treatments that have received regulatory clearance for this indication, and numerous compounds from various pharmacological classes are now in various stages of clinical studies for diabetic foot ulcers treatment. Multiple risk factors contribute to diabetic foot ulcers, including neuropathy, peripheral artery disease, infection, gender, cigarette smoking, and age. The present difficulties in diabetic foot ulcers treatment are related to bacterial resistance to currently utilized antibiotics. Inhibition of the quorum sensing (QS) system and targeting matrix metallopeptidase-9 (MMP-9) are promising. This study focuses on the difficulties of existing treatment, current treatment technique, and novel pharmacological targets for diabetic foot ulcer. The electronic data base search diabetic for literature on foot ulcers treatment was carried out using Science Direct, PubMed, Google-Scholar, Springer Link, Scopus, and Wiley up to 2021. Becaplermin, a medication that targets MMP-9, glyceryl trinitrate, which inhibits the bacterial quorum sensing system, probiotic therapy, and nano technological solutions are just a few of the novel pharmaceuticals being developed for diabetic foot ulcers treatment. A combination of therapies, rather than one particular agent, will be the best option for treatment of Diabetes foot ulcer since it is multifactorial factors that render occurs of diabetic foot ulcer.Keywords: diabetic foot ulcer, gangrene, probiotics, antimicrobial peptide
format	article
author	Jifar WW Atnafie SA Angalaparameswari S
author_facet	Jifar WW Atnafie SA Angalaparameswari S
author_sort	Jifar WW
title	A Review: Matrix Metallopeptidase-9 Nanoparticles Targeted for the Treatment of Diabetic Foot Ulcers
title_short	A Review: Matrix Metallopeptidase-9 Nanoparticles Targeted for the Treatment of Diabetic Foot Ulcers
title_full	A Review: Matrix Metallopeptidase-9 Nanoparticles Targeted for the Treatment of Diabetic Foot Ulcers
title_fullStr	A Review: Matrix Metallopeptidase-9 Nanoparticles Targeted for the Treatment of Diabetic Foot Ulcers
title_full_unstemmed	A Review: Matrix Metallopeptidase-9 Nanoparticles Targeted for the Treatment of Diabetic Foot Ulcers
title_sort	review: matrix metallopeptidase-9 nanoparticles targeted for the treatment of diabetic foot ulcers
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/6e22d687e42948de955f5b482ed88dc3
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A Review: Matrix Metallopeptidase-9 Nanoparticles Targeted for the Treatment of Diabetic Foot Ulcers

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