Treatment of intracranial meningioma with single-session and fractionated radiosurgery: a propensity score matching study

Treatment of intracranial meningioma with single-session and fractionated radiosurgery: a propensity score matching study

Abstract Single-session stereotactic radiosurgery (SSRS) is recognized as a safe and efficient treatment for meningioma. We aim to compare the long-term efficacy and safety of fractionated stereotactic radiotherapy (FSRT) with SSRS in the treatment of grade I meningioma. A total of 228 patients with...

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Autores principales: Sheng-Han Huang, Chun-Chieh Wang, Kuo-Chen Wei, Cheng-Nen Chang, Chi-Cheng Chuang, Hsien-Chih Chen, Ya-Jui Lin, Ko-Ting Chen, Ping-Ching Pai, Peng-Wei Hsu
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Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/6e243e376bd4419798a7d5ecfeaf0d7d
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spelling oai:doaj.org-article:6e243e376bd4419798a7d5ecfeaf0d7d2021-12-02T15:10:08ZTreatment of intracranial meningioma with single-session and fractionated radiosurgery: a propensity score matching study10.1038/s41598-020-75559-82045-2322https://doaj.org/article/6e243e376bd4419798a7d5ecfeaf0d7d2020-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-75559-8https://doaj.org/toc/2045-2322Abstract Single-session stereotactic radiosurgery (SSRS) is recognized as a safe and efficient treatment for meningioma. We aim to compare the long-term efficacy and safety of fractionated stereotactic radiotherapy (FSRT) with SSRS in the treatment of grade I meningioma. A total of 228 patients with 245 tumors treated with radiosurgery between March 2006 and June 2017were retrospectively evaluated. Of these, 147 (64.5%) patients were treated with SSRS. The remaining 81 patients (35.5%) were treated with a fractionated technique. Protocols to treat meningioma were classified as 12–16 Gy per fraction for SSRS and 7 Gy/fraction/day for three consecutive days to reach a total dose of 21 Gy for FSRT. In univariate and multivariate analyses, tumor volume was found to be associated with local control rate (hazard ratio = 4.98, p = 0.025). The difference in actuarial local control rate (LCR) between the SSRS and FSRT groups after propensity score matching (PSM) was not statistically significant during the 2-year (96.86% versus 100.00%, respectively; p = 0.175), 5-year (94.76% versus 97.56%, respectively; p = 0.373), and 10-year (74.40% versus 91.46%, respectively; p = 0.204) follow-up period. FSRT and SSRS were equally well-tolerated and effective for the treatment of intracranial benign meningioma during the10-year follow-up period.Sheng-Han HuangChun-Chieh WangKuo-Chen WeiCheng-Nen ChangChi-Cheng ChuangHsien-Chih ChenYa-Jui LinKo-Ting ChenPing-Ching PaiPeng-Wei HsuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Sheng-Han Huang
Chun-Chieh Wang
Kuo-Chen Wei
Cheng-Nen Chang
Chi-Cheng Chuang
Hsien-Chih Chen
Ya-Jui Lin
Ko-Ting Chen
Ping-Ching Pai
Peng-Wei Hsu
Treatment of intracranial meningioma with single-session and fractionated radiosurgery: a propensity score matching study
description Abstract Single-session stereotactic radiosurgery (SSRS) is recognized as a safe and efficient treatment for meningioma. We aim to compare the long-term efficacy and safety of fractionated stereotactic radiotherapy (FSRT) with SSRS in the treatment of grade I meningioma. A total of 228 patients with 245 tumors treated with radiosurgery between March 2006 and June 2017were retrospectively evaluated. Of these, 147 (64.5%) patients were treated with SSRS. The remaining 81 patients (35.5%) were treated with a fractionated technique. Protocols to treat meningioma were classified as 12–16 Gy per fraction for SSRS and 7 Gy/fraction/day for three consecutive days to reach a total dose of 21 Gy for FSRT. In univariate and multivariate analyses, tumor volume was found to be associated with local control rate (hazard ratio = 4.98, p = 0.025). The difference in actuarial local control rate (LCR) between the SSRS and FSRT groups after propensity score matching (PSM) was not statistically significant during the 2-year (96.86% versus 100.00%, respectively; p = 0.175), 5-year (94.76% versus 97.56%, respectively; p = 0.373), and 10-year (74.40% versus 91.46%, respectively; p = 0.204) follow-up period. FSRT and SSRS were equally well-tolerated and effective for the treatment of intracranial benign meningioma during the10-year follow-up period.
format article
author Sheng-Han Huang
Chun-Chieh Wang
Kuo-Chen Wei
Cheng-Nen Chang
Chi-Cheng Chuang
Hsien-Chih Chen
Ya-Jui Lin
Ko-Ting Chen
Ping-Ching Pai
Peng-Wei Hsu
author_facet Sheng-Han Huang
Chun-Chieh Wang
Kuo-Chen Wei
Cheng-Nen Chang
Chi-Cheng Chuang
Hsien-Chih Chen
Ya-Jui Lin
Ko-Ting Chen
Ping-Ching Pai
Peng-Wei Hsu
author_sort Sheng-Han Huang
title Treatment of intracranial meningioma with single-session and fractionated radiosurgery: a propensity score matching study
title_short Treatment of intracranial meningioma with single-session and fractionated radiosurgery: a propensity score matching study
title_full Treatment of intracranial meningioma with single-session and fractionated radiosurgery: a propensity score matching study
title_fullStr Treatment of intracranial meningioma with single-session and fractionated radiosurgery: a propensity score matching study
title_full_unstemmed Treatment of intracranial meningioma with single-session and fractionated radiosurgery: a propensity score matching study
title_sort treatment of intracranial meningioma with single-session and fractionated radiosurgery: a propensity score matching study
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/6e243e376bd4419798a7d5ecfeaf0d7d
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