Accelerating target deconvolution for therapeutic antibody candidates using highly parallelized genome editing

Efficient deconvolution of antibody targets is needed for phenotype-based discovery. Here, the authors investigate a deconvolution approach based on pooled CRISPR Cas9 to achieve 97% deconvolution success rate.

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Autores principales: Jenny Mattsson, Ludvig Ekdahl, Fredrik Junghus, Ram Ajore, Eva Erlandsson, Abhishek Niroula, Maroulio Pertesi, Björn Frendéus, Ingrid Teige, Björn Nilsson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/6e2a5135b9de48a8b79f53b16495e80f
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