Pioneer axons employ Cajal’s battering ram to enter the spinal cord

The fundamental mechanism of how sensory axons traverse a spinal cord glia limitans remains debatable, with some suggesting a role for boundary cap cells at the dorsal root entry zone (DREZ). Here, authors use time-lapse imaging of DRG axons at the DREZ to show that pioneer axons enter the DREZ befo...

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Autores principales:	Evan L. Nichols, Cody J. Smith
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6e2aa4d47cf2449ebffe915f4b37a3c7
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spelling	oai:doaj.org-article:6e2aa4d47cf2449ebffe915f4b37a3c72021-12-02T14:38:40ZPioneer axons employ Cajal’s battering ram to enter the spinal cord10.1038/s41467-019-08421-92041-1723https://doaj.org/article/6e2aa4d47cf2449ebffe915f4b37a3c72019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08421-9https://doaj.org/toc/2041-1723The fundamental mechanism of how sensory axons traverse a spinal cord glia limitans remains debatable, with some suggesting a role for boundary cap cells at the dorsal root entry zone (DREZ). Here, authors use time-lapse imaging of DRG axons at the DREZ to show that pioneer axons enter the DREZ before the presence of boundary cap cells, and that this entry is critically dependent on the development of actin-rich invasion structures reminiscent of invadopodia.Evan L. NicholsCody J. SmithNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Evan L. Nichols Cody J. Smith Pioneer axons employ Cajal’s battering ram to enter the spinal cord
description	The fundamental mechanism of how sensory axons traverse a spinal cord glia limitans remains debatable, with some suggesting a role for boundary cap cells at the dorsal root entry zone (DREZ). Here, authors use time-lapse imaging of DRG axons at the DREZ to show that pioneer axons enter the DREZ before the presence of boundary cap cells, and that this entry is critically dependent on the development of actin-rich invasion structures reminiscent of invadopodia.
format	article
author	Evan L. Nichols Cody J. Smith
author_facet	Evan L. Nichols Cody J. Smith
author_sort	Evan L. Nichols
title	Pioneer axons employ Cajal’s battering ram to enter the spinal cord
title_short	Pioneer axons employ Cajal’s battering ram to enter the spinal cord
title_full	Pioneer axons employ Cajal’s battering ram to enter the spinal cord
title_fullStr	Pioneer axons employ Cajal’s battering ram to enter the spinal cord
title_full_unstemmed	Pioneer axons employ Cajal’s battering ram to enter the spinal cord
title_sort	pioneer axons employ cajal’s battering ram to enter the spinal cord
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/6e2aa4d47cf2449ebffe915f4b37a3c7
work_keys_str_mv	AT evanlnichols pioneeraxonsemploycajalsbatteringramtoenterthespinalcord AT codyjsmith pioneeraxonsemploycajalsbatteringramtoenterthespinalcord
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Pioneer axons employ Cajal’s battering ram to enter the spinal cord

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