Identification of human IKK-2 inhibitors of natural origin (part I): modeling of the IKK-2 kinase domain, virtual screening and activity assays.

Identification of human IKK-2 inhibitors of natural origin (part I): modeling of the IKK-2 kinase domain, virtual screening and activity assays.

<h4>Background</h4>Their large scaffold diversity and properties, such as structural complexity and drug similarity, form the basis of claims that natural products are ideal starting points for drug design and development. Consequently, there has been great interest in determining whethe...

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Autores principales: Esther Sala, Laura Guasch, Justyna Iwaszkiewicz, Miquel Mulero, Maria-Josepa Salvadó, Montserrat Pinent, Vincent Zoete, Aurélien Grosdidier, Santiago Garcia-Vallvé, Olivier Michielin, Gerard Pujadas
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/6e2af70bae44479cbe1f505beba0d545
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