Circulating fatty acid profiles are associated with protein energy wasting in maintenance hemodialysis patients: a cross-sectional study

Abstract The metabolic impact of circulating fatty acids (FAs) in patients requiring hemodialysis (HD) is unknown. We investigated the associations between plasma triglyceride (TG) FAs and markers of inflammation, insulin resistance, nutritional status and body composition. Plasma TG-FAs were measur...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ban-Hock Khor, Sharmela Sahathevan, Ayesha Sualeheen, Mohammad Syafiq Md Ali, Sreelakshmi Sankara Narayanan, Karuthan Chinna, Abdul Halim Abdul Gafor, Bak-Leong Goh, Ghazali Ahmad, Zaki Morad, Zulfitri Azuan Mat Daud, Pramod Khosla, Kalyana Sundram, Tilakavati Karupaiah, PaTCH Investigators
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6e2d3e6e22eb479f8465f39e3c2b03b8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6e2d3e6e22eb479f8465f39e3c2b03b8
record_format	dspace
spelling	oai:doaj.org-article:6e2d3e6e22eb479f8465f39e3c2b03b82021-12-02T14:12:10ZCirculating fatty acid profiles are associated with protein energy wasting in maintenance hemodialysis patients: a cross-sectional study10.1038/s41598-020-80812-12045-2322https://doaj.org/article/6e2d3e6e22eb479f8465f39e3c2b03b82021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80812-1https://doaj.org/toc/2045-2322Abstract The metabolic impact of circulating fatty acids (FAs) in patients requiring hemodialysis (HD) is unknown. We investigated the associations between plasma triglyceride (TG) FAs and markers of inflammation, insulin resistance, nutritional status and body composition. Plasma TG-FAs were measured using gas chromatography in 341 patients on HD (age = 55.2 ± 14.0 years and 54.3% males). Cross-sectional associations of TG-FAs with 13 markers were examined using multivariate linear regression adjusted for potential confounders. Higher levels of TG saturated fatty acids were associated with greater body mass index (BMI, r = 0.230), waist circumference (r = 0.203), triceps skinfold (r = 0.197), fat tissue index (r = 0.150), serum insulin (r = 0.280), and homeostatic model assessment of insulin resistance (r = 0.276), but lower malnutrition inflammation score (MIS, r = − 0.160). Greater TG monounsaturated fatty acid levels were associated with lower lean tissue index (r = − 0.197) and serum albumin (r = − 0.188), but higher MIS (r = 0.176). Higher levels of TG n-3 polyunsaturated fatty acids (PUFAs) were associated with lower MIS (r = − 0.168) and interleukin-6 concentrations (r = − 0.115). Higher levels of TG n-6 PUFAs were associated with lower BMI (r = − 0.149) but greater serum albumin (r = 0.112). In conclusion, TG monounsaturated fatty acids were associated with poor nutritional status, while TG n-3 PUFAs were associated with good nutritional status. On the other hand, TG saturated fatty acids and TG n-6 PUFAs had both favorable and unfavorable associations with nutritional parameters.Ban-Hock KhorSharmela SahathevanAyesha SualeheenMohammad Syafiq Md AliSreelakshmi Sankara NarayananKaruthan ChinnaAbdul Halim Abdul GaforBak-Leong GohGhazali AhmadZaki MoradZulfitri Azuan Mat DaudPramod KhoslaKalyana SundramTilakavati KarupaiahPaTCH InvestigatorsNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ban-Hock Khor Sharmela Sahathevan Ayesha Sualeheen Mohammad Syafiq Md Ali Sreelakshmi Sankara Narayanan Karuthan Chinna Abdul Halim Abdul Gafor Bak-Leong Goh Ghazali Ahmad Zaki Morad Zulfitri Azuan Mat Daud Pramod Khosla Kalyana Sundram Tilakavati Karupaiah PaTCH Investigators Circulating fatty acid profiles are associated with protein energy wasting in maintenance hemodialysis patients: a cross-sectional study
description	Abstract The metabolic impact of circulating fatty acids (FAs) in patients requiring hemodialysis (HD) is unknown. We investigated the associations between plasma triglyceride (TG) FAs and markers of inflammation, insulin resistance, nutritional status and body composition. Plasma TG-FAs were measured using gas chromatography in 341 patients on HD (age = 55.2 ± 14.0 years and 54.3% males). Cross-sectional associations of TG-FAs with 13 markers were examined using multivariate linear regression adjusted for potential confounders. Higher levels of TG saturated fatty acids were associated with greater body mass index (BMI, r = 0.230), waist circumference (r = 0.203), triceps skinfold (r = 0.197), fat tissue index (r = 0.150), serum insulin (r = 0.280), and homeostatic model assessment of insulin resistance (r = 0.276), but lower malnutrition inflammation score (MIS, r = − 0.160). Greater TG monounsaturated fatty acid levels were associated with lower lean tissue index (r = − 0.197) and serum albumin (r = − 0.188), but higher MIS (r = 0.176). Higher levels of TG n-3 polyunsaturated fatty acids (PUFAs) were associated with lower MIS (r = − 0.168) and interleukin-6 concentrations (r = − 0.115). Higher levels of TG n-6 PUFAs were associated with lower BMI (r = − 0.149) but greater serum albumin (r = 0.112). In conclusion, TG monounsaturated fatty acids were associated with poor nutritional status, while TG n-3 PUFAs were associated with good nutritional status. On the other hand, TG saturated fatty acids and TG n-6 PUFAs had both favorable and unfavorable associations with nutritional parameters.
format	article
author	Ban-Hock Khor Sharmela Sahathevan Ayesha Sualeheen Mohammad Syafiq Md Ali Sreelakshmi Sankara Narayanan Karuthan Chinna Abdul Halim Abdul Gafor Bak-Leong Goh Ghazali Ahmad Zaki Morad Zulfitri Azuan Mat Daud Pramod Khosla Kalyana Sundram Tilakavati Karupaiah PaTCH Investigators
author_facet	Ban-Hock Khor Sharmela Sahathevan Ayesha Sualeheen Mohammad Syafiq Md Ali Sreelakshmi Sankara Narayanan Karuthan Chinna Abdul Halim Abdul Gafor Bak-Leong Goh Ghazali Ahmad Zaki Morad Zulfitri Azuan Mat Daud Pramod Khosla Kalyana Sundram Tilakavati Karupaiah PaTCH Investigators
author_sort	Ban-Hock Khor
title	Circulating fatty acid profiles are associated with protein energy wasting in maintenance hemodialysis patients: a cross-sectional study
title_short	Circulating fatty acid profiles are associated with protein energy wasting in maintenance hemodialysis patients: a cross-sectional study
title_full	Circulating fatty acid profiles are associated with protein energy wasting in maintenance hemodialysis patients: a cross-sectional study
title_fullStr	Circulating fatty acid profiles are associated with protein energy wasting in maintenance hemodialysis patients: a cross-sectional study
title_full_unstemmed	Circulating fatty acid profiles are associated with protein energy wasting in maintenance hemodialysis patients: a cross-sectional study
title_sort	circulating fatty acid profiles are associated with protein energy wasting in maintenance hemodialysis patients: a cross-sectional study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6e2d3e6e22eb479f8465f39e3c2b03b8
work_keys_str_mv	AT banhockkhor circulatingfattyacidprofilesareassociatedwithproteinenergywastinginmaintenancehemodialysispatientsacrosssectionalstudy AT sharmelasahathevan circulatingfattyacidprofilesareassociatedwithproteinenergywastinginmaintenancehemodialysispatientsacrosssectionalstudy AT ayeshasualeheen circulatingfattyacidprofilesareassociatedwithproteinenergywastinginmaintenancehemodialysispatientsacrosssectionalstudy AT mohammadsyafiqmdali circulatingfattyacidprofilesareassociatedwithproteinenergywastinginmaintenancehemodialysispatientsacrosssectionalstudy AT sreelakshmisankaranarayanan circulatingfattyacidprofilesareassociatedwithproteinenergywastinginmaintenancehemodialysispatientsacrosssectionalstudy AT karuthanchinna circulatingfattyacidprofilesareassociatedwithproteinenergywastinginmaintenancehemodialysispatientsacrosssectionalstudy AT abdulhalimabdulgafor circulatingfattyacidprofilesareassociatedwithproteinenergywastinginmaintenancehemodialysispatientsacrosssectionalstudy AT bakleonggoh circulatingfattyacidprofilesareassociatedwithproteinenergywastinginmaintenancehemodialysispatientsacrosssectionalstudy AT ghazaliahmad circulatingfattyacidprofilesareassociatedwithproteinenergywastinginmaintenancehemodialysispatientsacrosssectionalstudy AT zakimorad circulatingfattyacidprofilesareassociatedwithproteinenergywastinginmaintenancehemodialysispatientsacrosssectionalstudy AT zulfitriazuanmatdaud circulatingfattyacidprofilesareassociatedwithproteinenergywastinginmaintenancehemodialysispatientsacrosssectionalstudy AT pramodkhosla circulatingfattyacidprofilesareassociatedwithproteinenergywastinginmaintenancehemodialysispatientsacrosssectionalstudy AT kalyanasundram circulatingfattyacidprofilesareassociatedwithproteinenergywastinginmaintenancehemodialysispatientsacrosssectionalstudy AT tilakavatikarupaiah circulatingfattyacidprofilesareassociatedwithproteinenergywastinginmaintenancehemodialysispatientsacrosssectionalstudy AT patchinvestigators circulatingfattyacidprofilesareassociatedwithproteinenergywastinginmaintenancehemodialysispatientsacrosssectionalstudy
_version_	1718391789100990464

Circulating fatty acid profiles are associated with protein energy wasting in maintenance hemodialysis patients: a cross-sectional study

Ejemplares similares