Nutrient depletion-induced production of tri-acylated glycerophospholipids in Acinetobacter radioresistens

Abstract Bacteria inhabit a vast range of biological niches and have evolved diverse mechanisms to cope with environmental stressors. The genus Acinetobacter comprises a complex group of Gram-negative bacteria. Some of these bacteria such as A. baumannii are nosocomial pathogens. They are often resi...

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Auteurs principaux:	Yu Luo, Muhammad Afzal Javed, Harry Deneer, Xialu Chen
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Medicine R Science Q
Accès en ligne:	https://doaj.org/article/6e2de9471ea94fe390c1ecdffe4ebf8d
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spelling	oai:doaj.org-article:6e2de9471ea94fe390c1ecdffe4ebf8d2021-12-02T15:08:43ZNutrient depletion-induced production of tri-acylated glycerophospholipids in Acinetobacter radioresistens10.1038/s41598-018-25869-92045-2322https://doaj.org/article/6e2de9471ea94fe390c1ecdffe4ebf8d2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25869-9https://doaj.org/toc/2045-2322Abstract Bacteria inhabit a vast range of biological niches and have evolved diverse mechanisms to cope with environmental stressors. The genus Acinetobacter comprises a complex group of Gram-negative bacteria. Some of these bacteria such as A. baumannii are nosocomial pathogens. They are often resistant to multiple antibiotics and are associated with epidemic outbreaks. A. radioresistens is generally considered to be a commensal bacterium on human skin or an opportunistic pathogen. Interestingly, this species has exceptional resistance to a range of environmental challenges which contributes to its persistence in clinical environment and on human skin. We studied changes in its lipid composition induced by the onset of stationary phase. This strain produced triglycerides (TG) as well as four common phospholipids: phosphatidylethanolamine (PE), phosphatidylglycerol (PG), cardiolipin (CL) and lysocardiolipin (LCL). It also produced small amounts of acyl-phosphatidylglycerol (APG). As the bacterial growth entered the stationary phase, the lipidome switched from one dominated by PE and PG to another dominated by CL and LCL. Surprisingly, bacteria in the stationary phase produced N-acyl-phosphatidylethanolamine (NAPE) and another rare lipid we tentatively name as 1-phosphatidyl-2-acyl-glycero-3-phosphoethanolamine (PAGPE) based on tandem mass spectrometry. It is possible these tri-acylated lipids play an important role in coping with nutrient depletion.Yu LuoMuhammad Afzal JavedHarry DeneerXialu ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yu Luo Muhammad Afzal Javed Harry Deneer Xialu Chen Nutrient depletion-induced production of tri-acylated glycerophospholipids in Acinetobacter radioresistens
description	Abstract Bacteria inhabit a vast range of biological niches and have evolved diverse mechanisms to cope with environmental stressors. The genus Acinetobacter comprises a complex group of Gram-negative bacteria. Some of these bacteria such as A. baumannii are nosocomial pathogens. They are often resistant to multiple antibiotics and are associated with epidemic outbreaks. A. radioresistens is generally considered to be a commensal bacterium on human skin or an opportunistic pathogen. Interestingly, this species has exceptional resistance to a range of environmental challenges which contributes to its persistence in clinical environment and on human skin. We studied changes in its lipid composition induced by the onset of stationary phase. This strain produced triglycerides (TG) as well as four common phospholipids: phosphatidylethanolamine (PE), phosphatidylglycerol (PG), cardiolipin (CL) and lysocardiolipin (LCL). It also produced small amounts of acyl-phosphatidylglycerol (APG). As the bacterial growth entered the stationary phase, the lipidome switched from one dominated by PE and PG to another dominated by CL and LCL. Surprisingly, bacteria in the stationary phase produced N-acyl-phosphatidylethanolamine (NAPE) and another rare lipid we tentatively name as 1-phosphatidyl-2-acyl-glycero-3-phosphoethanolamine (PAGPE) based on tandem mass spectrometry. It is possible these tri-acylated lipids play an important role in coping with nutrient depletion.
format	article
author	Yu Luo Muhammad Afzal Javed Harry Deneer Xialu Chen
author_facet	Yu Luo Muhammad Afzal Javed Harry Deneer Xialu Chen
author_sort	Yu Luo
title	Nutrient depletion-induced production of tri-acylated glycerophospholipids in Acinetobacter radioresistens
title_short	Nutrient depletion-induced production of tri-acylated glycerophospholipids in Acinetobacter radioresistens
title_full	Nutrient depletion-induced production of tri-acylated glycerophospholipids in Acinetobacter radioresistens
title_fullStr	Nutrient depletion-induced production of tri-acylated glycerophospholipids in Acinetobacter radioresistens
title_full_unstemmed	Nutrient depletion-induced production of tri-acylated glycerophospholipids in Acinetobacter radioresistens
title_sort	nutrient depletion-induced production of tri-acylated glycerophospholipids in acinetobacter radioresistens
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/6e2de9471ea94fe390c1ecdffe4ebf8d
work_keys_str_mv	AT yuluo nutrientdepletioninducedproductionoftriacylatedglycerophospholipidsinacinetobacterradioresistens AT muhammadafzaljaved nutrientdepletioninducedproductionoftriacylatedglycerophospholipidsinacinetobacterradioresistens AT harrydeneer nutrientdepletioninducedproductionoftriacylatedglycerophospholipidsinacinetobacterradioresistens AT xialuchen nutrientdepletioninducedproductionoftriacylatedglycerophospholipidsinacinetobacterradioresistens
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Nutrient depletion-induced production of tri-acylated glycerophospholipids in Acinetobacter radioresistens

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