Levodopa-responsive depression associated with corticobasal degeneration: a case report

Natsumi Tarakita,1 Haruo Nishijima,2 Norio Yasui-Furukori1 1Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, 2Department of Neurology, Aomori Prefectural Central Hospital, Aomori, Japan Abstract: A 60-year-old female was treated for depression with the ant...

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Autores principales:	Tarakita N, Nishijima H, Yasui-Furukori N
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	corticobasal degeneration depression cognitive decline Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/6e2f411e7847477194d0c5c47b9989c7
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spelling	oai:doaj.org-article:6e2f411e7847477194d0c5c47b9989c72021-12-02T00:26:18ZLevodopa-responsive depression associated with corticobasal degeneration: a case report1178-2021https://doaj.org/article/6e2f411e7847477194d0c5c47b9989c72017-04-01T00:00:00Zhttps://www.dovepress.com/levodopa-responsive-depression-associated-with-corticobasal-degenerati-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Natsumi Tarakita,1 Haruo Nishijima,2 Norio Yasui-Furukori1 1Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, 2Department of Neurology, Aomori Prefectural Central Hospital, Aomori, Japan Abstract: A 60-year-old female was treated for depression with the antidepressant paroxetine for 13 years. The patient had experienced clumsiness and mild rigidity in the left hand, and had agraphia and mild subjective memory complaints for 3 years prior to admission in our hospital. She experienced exacerbated depression that included worsened depressive mood, lowered motivation, and suicidal ideation without precipitating stressful life events for 2 years prior to admission, and although she had continued taking the antidepressant, these symptoms were not ameliorated by increasing the dose of paroxetine. Following the development of myoclonus and pain in her left arm, we performed magnetic resonance imaging of her head, that revealed diffuse atrophy and right parietal lobe atrophy. The patient was ultimately diagnosed with corticobasal degeneration (CBD). Her left arm myoclonus and depression improved following levodopa administration. Therefore, we concluded that the recurrent depression may have been induced by CBD. Keywords: corticobasal degeneration, depression, cognitive declineTarakita NNishijima HYasui-Furukori NDove Medical Pressarticlecorticobasal degenerationdepressioncognitive declineNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 1107-1110 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	corticobasal degeneration depression cognitive decline Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	corticobasal degeneration depression cognitive decline Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Tarakita N Nishijima H Yasui-Furukori N Levodopa-responsive depression associated with corticobasal degeneration: a case report
description	Natsumi Tarakita,1 Haruo Nishijima,2 Norio Yasui-Furukori1 1Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, 2Department of Neurology, Aomori Prefectural Central Hospital, Aomori, Japan Abstract: A 60-year-old female was treated for depression with the antidepressant paroxetine for 13 years. The patient had experienced clumsiness and mild rigidity in the left hand, and had agraphia and mild subjective memory complaints for 3 years prior to admission in our hospital. She experienced exacerbated depression that included worsened depressive mood, lowered motivation, and suicidal ideation without precipitating stressful life events for 2 years prior to admission, and although she had continued taking the antidepressant, these symptoms were not ameliorated by increasing the dose of paroxetine. Following the development of myoclonus and pain in her left arm, we performed magnetic resonance imaging of her head, that revealed diffuse atrophy and right parietal lobe atrophy. The patient was ultimately diagnosed with corticobasal degeneration (CBD). Her left arm myoclonus and depression improved following levodopa administration. Therefore, we concluded that the recurrent depression may have been induced by CBD. Keywords: corticobasal degeneration, depression, cognitive decline
format	article
author	Tarakita N Nishijima H Yasui-Furukori N
author_facet	Tarakita N Nishijima H Yasui-Furukori N
author_sort	Tarakita N
title	Levodopa-responsive depression associated with corticobasal degeneration: a case report
title_short	Levodopa-responsive depression associated with corticobasal degeneration: a case report
title_full	Levodopa-responsive depression associated with corticobasal degeneration: a case report
title_fullStr	Levodopa-responsive depression associated with corticobasal degeneration: a case report
title_full_unstemmed	Levodopa-responsive depression associated with corticobasal degeneration: a case report
title_sort	levodopa-responsive depression associated with corticobasal degeneration: a case report
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/6e2f411e7847477194d0c5c47b9989c7
work_keys_str_mv	AT tarakitan levodoparesponsivedepressionassociatedwithcorticobasaldegenerationacasereport AT nishijimah levodoparesponsivedepressionassociatedwithcorticobasaldegenerationacasereport AT yasuifurukorin levodoparesponsivedepressionassociatedwithcorticobasaldegenerationacasereport
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Levodopa-responsive depression associated with corticobasal degeneration: a case report

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