Toward a Predictive Understanding of Earth’s Microbiomes to Address 21st Century Challenges

ABSTRACT Microorganisms have shaped our planet and its inhabitants for over 3.5 billion years. Humankind has had a profound influence on the biosphere, manifested as global climate and land use changes, and extensive urbanization in response to a growing population. The challenges we face to supply...

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Autores principales:	Martin J. Blaser, Zoe G. Cardon, Mildred K. Cho, Jeffrey L. Dangl, Timothy J. Donohue, Jessica L. Green, Rob Knight, Mary E. Maxon, Trent R. Northen, Katherine S. Pollard, Eoin L. Brodie
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2016
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/6e31615ee3424fc1a1ed897468114f11
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spelling	oai:doaj.org-article:6e31615ee3424fc1a1ed897468114f112021-11-15T15:50:17ZToward a Predictive Understanding of Earth’s Microbiomes to Address 21st Century Challenges10.1128/mBio.00714-162150-7511https://doaj.org/article/6e31615ee3424fc1a1ed897468114f112016-07-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00714-16https://doaj.org/toc/2150-7511ABSTRACT Microorganisms have shaped our planet and its inhabitants for over 3.5 billion years. Humankind has had a profound influence on the biosphere, manifested as global climate and land use changes, and extensive urbanization in response to a growing population. The challenges we face to supply food, energy, and clean water while maintaining and improving the health of our population and ecosystems are significant. Given the extensive influence of microorganisms across our biosphere, we propose that a coordinated, cross-disciplinary effort is required to understand, predict, and harness microbiome function. From the parallelization of gene function testing to precision manipulation of genes, communities, and model ecosystems and development of novel analytical and simulation approaches, we outline strategies to move microbiome research into an era of causality. These efforts will improve prediction of ecosystem response and enable the development of new, responsible, microbiome-based solutions to significant challenges of our time.Martin J. BlaserZoe G. CardonMildred K. ChoJeffrey L. DanglTimothy J. DonohueJessica L. GreenRob KnightMary E. MaxonTrent R. NorthenKatherine S. PollardEoin L. BrodieAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 7, Iss 3 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Martin J. Blaser Zoe G. Cardon Mildred K. Cho Jeffrey L. Dangl Timothy J. Donohue Jessica L. Green Rob Knight Mary E. Maxon Trent R. Northen Katherine S. Pollard Eoin L. Brodie Toward a Predictive Understanding of Earth’s Microbiomes to Address 21st Century Challenges
description	ABSTRACT Microorganisms have shaped our planet and its inhabitants for over 3.5 billion years. Humankind has had a profound influence on the biosphere, manifested as global climate and land use changes, and extensive urbanization in response to a growing population. The challenges we face to supply food, energy, and clean water while maintaining and improving the health of our population and ecosystems are significant. Given the extensive influence of microorganisms across our biosphere, we propose that a coordinated, cross-disciplinary effort is required to understand, predict, and harness microbiome function. From the parallelization of gene function testing to precision manipulation of genes, communities, and model ecosystems and development of novel analytical and simulation approaches, we outline strategies to move microbiome research into an era of causality. These efforts will improve prediction of ecosystem response and enable the development of new, responsible, microbiome-based solutions to significant challenges of our time.
format	article
author	Martin J. Blaser Zoe G. Cardon Mildred K. Cho Jeffrey L. Dangl Timothy J. Donohue Jessica L. Green Rob Knight Mary E. Maxon Trent R. Northen Katherine S. Pollard Eoin L. Brodie
author_facet	Martin J. Blaser Zoe G. Cardon Mildred K. Cho Jeffrey L. Dangl Timothy J. Donohue Jessica L. Green Rob Knight Mary E. Maxon Trent R. Northen Katherine S. Pollard Eoin L. Brodie
author_sort	Martin J. Blaser
title	Toward a Predictive Understanding of Earth’s Microbiomes to Address 21st Century Challenges
title_short	Toward a Predictive Understanding of Earth’s Microbiomes to Address 21st Century Challenges
title_full	Toward a Predictive Understanding of Earth’s Microbiomes to Address 21st Century Challenges
title_fullStr	Toward a Predictive Understanding of Earth’s Microbiomes to Address 21st Century Challenges
title_full_unstemmed	Toward a Predictive Understanding of Earth’s Microbiomes to Address 21st Century Challenges
title_sort	toward a predictive understanding of earth’s microbiomes to address 21st century challenges
publisher	American Society for Microbiology
publishDate	2016
url	https://doaj.org/article/6e31615ee3424fc1a1ed897468114f11
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Toward a Predictive Understanding of Earth’s Microbiomes to Address 21st Century Challenges

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