Miro clusters regulate ER-mitochondria contact sites and link cristae organization to the mitochondrial transport machinery

Mitochondrial cristae organization and ER-mitochondria contact sites are critical structures for cellular function. Here, the authors use super-resolution microscopy to show that Miro GTPases form clusters required for normal ER-mitochondria contact sites formation and to link cristae organization t...

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Autores principales:	Souvik Modi, Guillermo López-Doménech, Elise F. Halff, Christian Covill-Cooke, Davor Ivankovic, Daniela Melandri, I. Lorena Arancibia-Cárcamo, Jemima J. Burden, Alan R. Lowe, Josef T. Kittler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6e3613542ef2495e88ae0b5d98544574
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spelling	oai:doaj.org-article:6e3613542ef2495e88ae0b5d985445742021-12-02T17:02:10ZMiro clusters regulate ER-mitochondria contact sites and link cristae organization to the mitochondrial transport machinery10.1038/s41467-019-12382-42041-1723https://doaj.org/article/6e3613542ef2495e88ae0b5d985445742019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12382-4https://doaj.org/toc/2041-1723Mitochondrial cristae organization and ER-mitochondria contact sites are critical structures for cellular function. Here, the authors use super-resolution microscopy to show that Miro GTPases form clusters required for normal ER-mitochondria contact sites formation and to link cristae organization to the mitochondrial transport machinery.Souvik ModiGuillermo López-DoménechElise F. HalffChristian Covill-CookeDavor IvankovicDaniela MelandriI. Lorena Arancibia-CárcamoJemima J. BurdenAlan R. LoweJosef T. KittlerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Souvik Modi Guillermo López-Doménech Elise F. Halff Christian Covill-Cooke Davor Ivankovic Daniela Melandri I. Lorena Arancibia-Cárcamo Jemima J. Burden Alan R. Lowe Josef T. Kittler Miro clusters regulate ER-mitochondria contact sites and link cristae organization to the mitochondrial transport machinery
description	Mitochondrial cristae organization and ER-mitochondria contact sites are critical structures for cellular function. Here, the authors use super-resolution microscopy to show that Miro GTPases form clusters required for normal ER-mitochondria contact sites formation and to link cristae organization to the mitochondrial transport machinery.
format	article
author	Souvik Modi Guillermo López-Doménech Elise F. Halff Christian Covill-Cooke Davor Ivankovic Daniela Melandri I. Lorena Arancibia-Cárcamo Jemima J. Burden Alan R. Lowe Josef T. Kittler
author_facet	Souvik Modi Guillermo López-Doménech Elise F. Halff Christian Covill-Cooke Davor Ivankovic Daniela Melandri I. Lorena Arancibia-Cárcamo Jemima J. Burden Alan R. Lowe Josef T. Kittler
author_sort	Souvik Modi
title	Miro clusters regulate ER-mitochondria contact sites and link cristae organization to the mitochondrial transport machinery
title_short	Miro clusters regulate ER-mitochondria contact sites and link cristae organization to the mitochondrial transport machinery
title_full	Miro clusters regulate ER-mitochondria contact sites and link cristae organization to the mitochondrial transport machinery
title_fullStr	Miro clusters regulate ER-mitochondria contact sites and link cristae organization to the mitochondrial transport machinery
title_full_unstemmed	Miro clusters regulate ER-mitochondria contact sites and link cristae organization to the mitochondrial transport machinery
title_sort	miro clusters regulate er-mitochondria contact sites and link cristae organization to the mitochondrial transport machinery
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/6e3613542ef2495e88ae0b5d98544574
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Miro clusters regulate ER-mitochondria contact sites and link cristae organization to the mitochondrial transport machinery

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