Nicotinamide riboside kinase structures reveal new pathways to NAD+.
The eukaryotic nicotinamide riboside kinase (Nrk) pathway, which is induced in response to nerve damage and promotes replicative life span in yeast, converts nicotinamide riboside to nicotinamide adenine dinucleotide (NAD+) by phosphorylation and adenylylation. Crystal structures of human Nrk1 bound...
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Auteurs principaux: | Wolfram Tempel, Wael M Rabeh, Katrina L Bogan, Peter Belenky, Marzena Wojcik, Heather F Seidle, Lyudmila Nedyalkova, Tianle Yang, Anthony A Sauve, Hee-Won Park, Charles Brenner |
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Format: | article |
Langue: | EN |
Publié: |
Public Library of Science (PLoS)
2007
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Accès en ligne: | https://doaj.org/article/6e381eb8f8a6473f955a9c049c6e9369 |
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