CHEMERIN AS A POTENTIAL REGULATOR OF MITOCHONDRIAL QUALITY CONTROL IN OBESE PATIENTS

In obese patients, the relationship between the content of chemerin in blood plasma and the expression of genes TFAM, Drp1, MFN2, SOD, BAX, responsible for quality control of mitochondria, in insulin-dependent tissues (adipose tissue, liver) was revealed. The tissue-specific features of gene express...

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Autores principales:	M. A. Vulf, D. A. Shunkina (Skuratovskaia), V. Hung, A. A. Komar, P. A. Zatolokin, E. V. Kirienkova, N. D. Gazatova, L. S. Litvinova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2021
Materias:	obesity t2dm mitochondria chemerin liver adipose tissue mtdna Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/6e3c5b1a82214d2f8e68ce273de571ad
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spelling	oai:doaj.org-article:6e3c5b1a82214d2f8e68ce273de571ad2021-11-18T08:03:51ZCHEMERIN AS A POTENTIAL REGULATOR OF MITOCHONDRIAL QUALITY CONTROL IN OBESE PATIENTS1563-06252313-741X10.15789/1563-0625-CAA-2227https://doaj.org/article/6e3c5b1a82214d2f8e68ce273de571ad2021-10-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/2433https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XIn obese patients, the relationship between the content of chemerin in blood plasma and the expression of genes TFAM, Drp1, MFN2, SOD, BAX, responsible for quality control of mitochondria, in insulin-dependent tissues (adipose tissue, liver) was revealed. The tissue-specific features of gene expression (TFAM, Drp1, MFN2, SOD, BAX), the number of mtDNA copies in the studied depots in obese patients were established. It has been proven that a change (decrease) in the number of mtDNA copies in insulin-dependent tissues can have a protective effect on mitochondria under conditions of increased oxidative stress. It was found that in patients without type 2 diabetes, an increase in chemerin production promotes the activation of the antioxidant system in the visceral adipose tissue but not in the liver. On the contrary, all obese patients with type 2 diabetes showed a decrease (compared with patients without type 2 diabetes) in the plasma level of chemerin. Thus, the low content of chemerin in the blood plasma in patients with type 2 diabetes mediates the formation of mitochondrial dysfunction in insulin-dependent tissues (adipose tissue, liver).M. A. VulfD. A. Shunkina (Skuratovskaia)V. HungA. A. KomarP. A. ZatolokinE. V. KirienkovaN. D. GazatovaL. S. LitvinovaSPb RAACIarticleobesityt2dmmitochondriachemerinliveradipose tissuemtdnaImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 23, Iss 4, Pp 881-886 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	obesity t2dm mitochondria chemerin liver adipose tissue mtdna Immunologic diseases. Allergy RC581-607
spellingShingle	obesity t2dm mitochondria chemerin liver adipose tissue mtdna Immunologic diseases. Allergy RC581-607 M. A. Vulf D. A. Shunkina (Skuratovskaia) V. Hung A. A. Komar P. A. Zatolokin E. V. Kirienkova N. D. Gazatova L. S. Litvinova CHEMERIN AS A POTENTIAL REGULATOR OF MITOCHONDRIAL QUALITY CONTROL IN OBESE PATIENTS
description	In obese patients, the relationship between the content of chemerin in blood plasma and the expression of genes TFAM, Drp1, MFN2, SOD, BAX, responsible for quality control of mitochondria, in insulin-dependent tissues (adipose tissue, liver) was revealed. The tissue-specific features of gene expression (TFAM, Drp1, MFN2, SOD, BAX), the number of mtDNA copies in the studied depots in obese patients were established. It has been proven that a change (decrease) in the number of mtDNA copies in insulin-dependent tissues can have a protective effect on mitochondria under conditions of increased oxidative stress. It was found that in patients without type 2 diabetes, an increase in chemerin production promotes the activation of the antioxidant system in the visceral adipose tissue but not in the liver. On the contrary, all obese patients with type 2 diabetes showed a decrease (compared with patients without type 2 diabetes) in the plasma level of chemerin. Thus, the low content of chemerin in the blood plasma in patients with type 2 diabetes mediates the formation of mitochondrial dysfunction in insulin-dependent tissues (adipose tissue, liver).
format	article
author	M. A. Vulf D. A. Shunkina (Skuratovskaia) V. Hung A. A. Komar P. A. Zatolokin E. V. Kirienkova N. D. Gazatova L. S. Litvinova
author_facet	M. A. Vulf D. A. Shunkina (Skuratovskaia) V. Hung A. A. Komar P. A. Zatolokin E. V. Kirienkova N. D. Gazatova L. S. Litvinova
author_sort	M. A. Vulf
title	CHEMERIN AS A POTENTIAL REGULATOR OF MITOCHONDRIAL QUALITY CONTROL IN OBESE PATIENTS
title_short	CHEMERIN AS A POTENTIAL REGULATOR OF MITOCHONDRIAL QUALITY CONTROL IN OBESE PATIENTS
title_full	CHEMERIN AS A POTENTIAL REGULATOR OF MITOCHONDRIAL QUALITY CONTROL IN OBESE PATIENTS
title_fullStr	CHEMERIN AS A POTENTIAL REGULATOR OF MITOCHONDRIAL QUALITY CONTROL IN OBESE PATIENTS
title_full_unstemmed	CHEMERIN AS A POTENTIAL REGULATOR OF MITOCHONDRIAL QUALITY CONTROL IN OBESE PATIENTS
title_sort	chemerin as a potential regulator of mitochondrial quality control in obese patients
publisher	SPb RAACI
publishDate	2021
url	https://doaj.org/article/6e3c5b1a82214d2f8e68ce273de571ad
work_keys_str_mv	AT mavulf chemerinasapotentialregulatorofmitochondrialqualitycontrolinobesepatients AT dashunkinaskuratovskaia chemerinasapotentialregulatorofmitochondrialqualitycontrolinobesepatients AT vhung chemerinasapotentialregulatorofmitochondrialqualitycontrolinobesepatients AT aakomar chemerinasapotentialregulatorofmitochondrialqualitycontrolinobesepatients AT pazatolokin chemerinasapotentialregulatorofmitochondrialqualitycontrolinobesepatients AT evkirienkova chemerinasapotentialregulatorofmitochondrialqualitycontrolinobesepatients AT ndgazatova chemerinasapotentialregulatorofmitochondrialqualitycontrolinobesepatients AT lslitvinova chemerinasapotentialregulatorofmitochondrialqualitycontrolinobesepatients
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CHEMERIN AS A POTENTIAL REGULATOR OF MITOCHONDRIAL QUALITY CONTROL IN OBESE PATIENTS

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