The Hidden Link of Exosomes to Head and Neck Cancer

Head and neck squamous cell carcinoma (HNSCC) represents an aggressive and heterogenous group of cancers whose pathologies remain largely unresolved. Despite recent advances in HNSCC therapeutic strategies, the overall survival of HNSCC patients remains poor and continues to prompt efforts to develo...

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Autores principales:	Yong Teng, Lixia Gao, Reid Loveless, Juan P. Rodrigo, Primož Strojan, Stefan M. Willems, Cherie-Ann Nathan, Antti A. Mäkitie, Nabil F. Saba, Alfio Ferlito
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	exosomes head and neck squamous cell carcinoma the tumor microenvironment biomarker therapeutic targets Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/6e46bcabcc1b47d4998e0ada9b0e7f36
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spelling	oai:doaj.org-article:6e46bcabcc1b47d4998e0ada9b0e7f362021-11-25T17:04:11ZThe Hidden Link of Exosomes to Head and Neck Cancer10.3390/cancers132258022072-6694https://doaj.org/article/6e46bcabcc1b47d4998e0ada9b0e7f362021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5802https://doaj.org/toc/2072-6694Head and neck squamous cell carcinoma (HNSCC) represents an aggressive and heterogenous group of cancers whose pathologies remain largely unresolved. Despite recent advances in HNSCC therapeutic strategies, the overall survival of HNSCC patients remains poor and continues to prompt efforts to develop more effective therapies. Exosomes are a subtype of extracellular vesicles secreted by a variety of cells that have begun to spark significant interest in their roles in cancer. As membranous vesicles, spanning from 30–150 nm in diameter, exosomes mediate the transport of various molecules, such as proteins, nucleic acids, and lipids, intercellularly throughout the body. In doing so, exosomes not only act to deliver materials to cancer cells but also as signals that can confer their progression. Accumulating evidence shows the direct correlation between exosomes and the aggressiveness of HNSCC. However, more research is warranted in this field to further our understanding. In this review, we attempt to highlight the tumor-supporting roles and therapeutic potential of exosomes in HNSCC. We introduce first the biogenesis and component features of exosomes, followed by their involvement in HNSCC proliferation and metastasis. We then move on to discuss HNSCC-derived exosomes’ influence on the tumor microenvironment and their function in tumor drug resistance. Finally, we explore the promising potential of exosomes as HNSCC biomarkers and therapeutic targets and drug carriers for HNSCC treatments.Yong TengLixia GaoReid LovelessJuan P. RodrigoPrimož StrojanStefan M. WillemsCherie-Ann NathanAntti A. MäkitieNabil F. SabaAlfio FerlitoMDPI AGarticleexosomeshead and neck squamous cell carcinomathe tumor microenvironmentbiomarkertherapeutic targetsNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5802, p 5802 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	exosomes head and neck squamous cell carcinoma the tumor microenvironment biomarker therapeutic targets Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	exosomes head and neck squamous cell carcinoma the tumor microenvironment biomarker therapeutic targets Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Yong Teng Lixia Gao Reid Loveless Juan P. Rodrigo Primož Strojan Stefan M. Willems Cherie-Ann Nathan Antti A. Mäkitie Nabil F. Saba Alfio Ferlito The Hidden Link of Exosomes to Head and Neck Cancer
description	Head and neck squamous cell carcinoma (HNSCC) represents an aggressive and heterogenous group of cancers whose pathologies remain largely unresolved. Despite recent advances in HNSCC therapeutic strategies, the overall survival of HNSCC patients remains poor and continues to prompt efforts to develop more effective therapies. Exosomes are a subtype of extracellular vesicles secreted by a variety of cells that have begun to spark significant interest in their roles in cancer. As membranous vesicles, spanning from 30–150 nm in diameter, exosomes mediate the transport of various molecules, such as proteins, nucleic acids, and lipids, intercellularly throughout the body. In doing so, exosomes not only act to deliver materials to cancer cells but also as signals that can confer their progression. Accumulating evidence shows the direct correlation between exosomes and the aggressiveness of HNSCC. However, more research is warranted in this field to further our understanding. In this review, we attempt to highlight the tumor-supporting roles and therapeutic potential of exosomes in HNSCC. We introduce first the biogenesis and component features of exosomes, followed by their involvement in HNSCC proliferation and metastasis. We then move on to discuss HNSCC-derived exosomes’ influence on the tumor microenvironment and their function in tumor drug resistance. Finally, we explore the promising potential of exosomes as HNSCC biomarkers and therapeutic targets and drug carriers for HNSCC treatments.
format	article
author	Yong Teng Lixia Gao Reid Loveless Juan P. Rodrigo Primož Strojan Stefan M. Willems Cherie-Ann Nathan Antti A. Mäkitie Nabil F. Saba Alfio Ferlito
author_facet	Yong Teng Lixia Gao Reid Loveless Juan P. Rodrigo Primož Strojan Stefan M. Willems Cherie-Ann Nathan Antti A. Mäkitie Nabil F. Saba Alfio Ferlito
author_sort	Yong Teng
title	The Hidden Link of Exosomes to Head and Neck Cancer
title_short	The Hidden Link of Exosomes to Head and Neck Cancer
title_full	The Hidden Link of Exosomes to Head and Neck Cancer
title_fullStr	The Hidden Link of Exosomes to Head and Neck Cancer
title_full_unstemmed	The Hidden Link of Exosomes to Head and Neck Cancer
title_sort	hidden link of exosomes to head and neck cancer
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6e46bcabcc1b47d4998e0ada9b0e7f36
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The Hidden Link of Exosomes to Head and Neck Cancer

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