Risk factor profile of coronary artery disease in black South Africans

Objectives: The aim of this study was to investigate the risk factor profile of coronary artery disease (CAD) in black South Africans. The study was motivated by the increased prevalence of CAD in South Africa, probably as a result of urbanisation. Despite this increase, however, very little is know...

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Autores principales:	Robin Dolman, Lucas Ntyintyane, Johann Jerling, Frederick Raal
Formato:	article
Lenguaje:	EN
Publicado:	South African Heart Association 2017
Materias:	coronary artery disease black south africans cardiovascular disease Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/6e4a918bd6ec49fc97d7c0508337e9f6
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spelling	oai:doaj.org-article:6e4a918bd6ec49fc97d7c0508337e9f62021-11-26T14:02:16ZRisk factor profile of coronary artery disease in black South Africans10.24170/8-1-19191996-67412071-4602https://doaj.org/article/6e4a918bd6ec49fc97d7c0508337e9f62017-04-01T00:00:00Zhttps://www.journals.ac.za/index.php/SAHJ/article/view/1919https://doaj.org/toc/1996-6741https://doaj.org/toc/2071-4602Objectives: The aim of this study was to investigate the risk factor profile of coronary artery disease (CAD) in black South Africans. The study was motivated by the increased prevalence of CAD in South Africa, probably as a result of urbanisation. Despite this increase, however, very little is known regarding the cause, risk factor profile and clinical presentations of CAD in the black South African population. Design: A case control study was performed investigating 40 (33 men, 7 women) angiographically defined CAD patients and 20 (13 men and 7 women) age and body composition matched controls. Results: There was no difference in physical activity, sociodemographic factors or dietary intakes between the CAD and control group, except for the CAD patients consuming less vit C (40.9 vs 61.3 mg). The CAD group had significantly higher LDL-C, fasting glucose and CRP. There was also a significantly higher prevalence of smokers (35 vs 10%), hypertension (95 vs 75%) small dense LDL (73 vs 15%) and insulin resistance (M-value of 4.15 vs 12.5 mg/kg/min) in the CAD compared to the control group. In a logistic regression model, small dense LDL and insulin resistance were the main predictors of CAD. Conclusions: Black South African CAD patients had increased levels of the same risk factors that are typically seen in Caucasians with insulin resistance and small dense LDL being particularly significant in their contribution.Robin DolmanLucas NtyintyaneJohann JerlingFrederick RaalSouth African Heart Associationarticlecoronary artery diseaseblack south africanscardiovascular diseaseDiseases of the circulatory (Cardiovascular) systemRC666-701ENSA Heart Journal, Vol 8, Iss 1, Pp 4-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	coronary artery disease black south africans cardiovascular disease Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	coronary artery disease black south africans cardiovascular disease Diseases of the circulatory (Cardiovascular) system RC666-701 Robin Dolman Lucas Ntyintyane Johann Jerling Frederick Raal Risk factor profile of coronary artery disease in black South Africans
description	Objectives: The aim of this study was to investigate the risk factor profile of coronary artery disease (CAD) in black South Africans. The study was motivated by the increased prevalence of CAD in South Africa, probably as a result of urbanisation. Despite this increase, however, very little is known regarding the cause, risk factor profile and clinical presentations of CAD in the black South African population. Design: A case control study was performed investigating 40 (33 men, 7 women) angiographically defined CAD patients and 20 (13 men and 7 women) age and body composition matched controls. Results: There was no difference in physical activity, sociodemographic factors or dietary intakes between the CAD and control group, except for the CAD patients consuming less vit C (40.9 vs 61.3 mg). The CAD group had significantly higher LDL-C, fasting glucose and CRP. There was also a significantly higher prevalence of smokers (35 vs 10%), hypertension (95 vs 75%) small dense LDL (73 vs 15%) and insulin resistance (M-value of 4.15 vs 12.5 mg/kg/min) in the CAD compared to the control group. In a logistic regression model, small dense LDL and insulin resistance were the main predictors of CAD. Conclusions: Black South African CAD patients had increased levels of the same risk factors that are typically seen in Caucasians with insulin resistance and small dense LDL being particularly significant in their contribution.
format	article
author	Robin Dolman Lucas Ntyintyane Johann Jerling Frederick Raal
author_facet	Robin Dolman Lucas Ntyintyane Johann Jerling Frederick Raal
author_sort	Robin Dolman
title	Risk factor profile of coronary artery disease in black South Africans
title_short	Risk factor profile of coronary artery disease in black South Africans
title_full	Risk factor profile of coronary artery disease in black South Africans
title_fullStr	Risk factor profile of coronary artery disease in black South Africans
title_full_unstemmed	Risk factor profile of coronary artery disease in black South Africans
title_sort	risk factor profile of coronary artery disease in black south africans
publisher	South African Heart Association
publishDate	2017
url	https://doaj.org/article/6e4a918bd6ec49fc97d7c0508337e9f6
work_keys_str_mv	AT robindolman riskfactorprofileofcoronaryarterydiseaseinblacksouthafricans AT lucasntyintyane riskfactorprofileofcoronaryarterydiseaseinblacksouthafricans AT johannjerling riskfactorprofileofcoronaryarterydiseaseinblacksouthafricans AT frederickraal riskfactorprofileofcoronaryarterydiseaseinblacksouthafricans
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Risk factor profile of coronary artery disease in black South Africans

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