Host factors determine anti-GM1 response following oral challenge of chickens with Guillain-Barré syndrome derived Campylobacter jejuni strain GB11.

<h4>Background</h4>Anti-ganglioside antibodies with a pathogenic potential are present in C. jejuni-associated Guillain-Barré syndrome (GBS) patients and are probably induced by molecular mimicry. Immunization studies in rabbits and mice have demonstrated that these anti-ganglioside anti...

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Autores principales:	C Wim Ang, Jeroen R Dijkstra, Marcel A de Klerk, Hubert Ph Endtz, Pieter A van Doorn, Bart C Jacobs, Suzan H M Jeurissen, Jaap A Wagenaar
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6e4c4a336b7f4e48add3391f1ea9d275
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spelling	oai:doaj.org-article:6e4c4a336b7f4e48add3391f1ea9d2752021-11-25T06:25:16ZHost factors determine anti-GM1 response following oral challenge of chickens with Guillain-Barré syndrome derived Campylobacter jejuni strain GB11.1932-620310.1371/journal.pone.0009820https://doaj.org/article/6e4c4a336b7f4e48add3391f1ea9d2752010-03-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20339556/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Anti-ganglioside antibodies with a pathogenic potential are present in C. jejuni-associated Guillain-Barré syndrome (GBS) patients and are probably induced by molecular mimicry. Immunization studies in rabbits and mice have demonstrated that these anti-ganglioside antibodies can be induced using purified lipo-oligosaccharides (LOS) from C. jejuni in a strong adjuvant.<h4>Methodology/principal findings</h4>To investigate whether natural colonization of chickens with a ganglioside-mimicking C. jejuni strain induces an anti-ganglioside response, and to investigate the diversity in anti-ganglioside response between and within genetically different chicken lines, we orally challenged chickens with different C. jejuni strains. Oral challenge of chickens with a C. jejuni strain from a GBS patient, containing a LOS that mimics ganglioside GM1, induced specific IgM and IgG anti-LOS and anti-GM1 antibodies. Inoculation of chickens with the Penner HS:3 serostrain, without a GM1-like structure, induced anti-LOS but no anti-ganglioside antibodies. We observed different patterns of anti-LOS/ganglioside response between and within the five strains of chickens.<h4>Conclusions</h4>Natural infection of chickens with C. jejuni induces anti-ganglioside antibodies. The production of antibodies is governed by both microbial and host factors.C Wim AngJeroen R DijkstraMarcel A de KlerkHubert Ph EndtzPieter A van DoornBart C JacobsSuzan H M JeurissenJaap A WagenaarPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 3, p e9820 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q C Wim Ang Jeroen R Dijkstra Marcel A de Klerk Hubert Ph Endtz Pieter A van Doorn Bart C Jacobs Suzan H M Jeurissen Jaap A Wagenaar Host factors determine anti-GM1 response following oral challenge of chickens with Guillain-Barré syndrome derived Campylobacter jejuni strain GB11.
description	<h4>Background</h4>Anti-ganglioside antibodies with a pathogenic potential are present in C. jejuni-associated Guillain-Barré syndrome (GBS) patients and are probably induced by molecular mimicry. Immunization studies in rabbits and mice have demonstrated that these anti-ganglioside antibodies can be induced using purified lipo-oligosaccharides (LOS) from C. jejuni in a strong adjuvant.<h4>Methodology/principal findings</h4>To investigate whether natural colonization of chickens with a ganglioside-mimicking C. jejuni strain induces an anti-ganglioside response, and to investigate the diversity in anti-ganglioside response between and within genetically different chicken lines, we orally challenged chickens with different C. jejuni strains. Oral challenge of chickens with a C. jejuni strain from a GBS patient, containing a LOS that mimics ganglioside GM1, induced specific IgM and IgG anti-LOS and anti-GM1 antibodies. Inoculation of chickens with the Penner HS:3 serostrain, without a GM1-like structure, induced anti-LOS but no anti-ganglioside antibodies. We observed different patterns of anti-LOS/ganglioside response between and within the five strains of chickens.<h4>Conclusions</h4>Natural infection of chickens with C. jejuni induces anti-ganglioside antibodies. The production of antibodies is governed by both microbial and host factors.
format	article
author	C Wim Ang Jeroen R Dijkstra Marcel A de Klerk Hubert Ph Endtz Pieter A van Doorn Bart C Jacobs Suzan H M Jeurissen Jaap A Wagenaar
author_facet	C Wim Ang Jeroen R Dijkstra Marcel A de Klerk Hubert Ph Endtz Pieter A van Doorn Bart C Jacobs Suzan H M Jeurissen Jaap A Wagenaar
author_sort	C Wim Ang
title	Host factors determine anti-GM1 response following oral challenge of chickens with Guillain-Barré syndrome derived Campylobacter jejuni strain GB11.
title_short	Host factors determine anti-GM1 response following oral challenge of chickens with Guillain-Barré syndrome derived Campylobacter jejuni strain GB11.
title_full	Host factors determine anti-GM1 response following oral challenge of chickens with Guillain-Barré syndrome derived Campylobacter jejuni strain GB11.
title_fullStr	Host factors determine anti-GM1 response following oral challenge of chickens with Guillain-Barré syndrome derived Campylobacter jejuni strain GB11.
title_full_unstemmed	Host factors determine anti-GM1 response following oral challenge of chickens with Guillain-Barré syndrome derived Campylobacter jejuni strain GB11.
title_sort	host factors determine anti-gm1 response following oral challenge of chickens with guillain-barré syndrome derived campylobacter jejuni strain gb11.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/6e4c4a336b7f4e48add3391f1ea9d275
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Host factors determine anti-GM1 response following oral challenge of chickens with Guillain-Barré syndrome derived Campylobacter jejuni strain GB11.

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