Missing self triggers NK cell-mediated chronic vascular rejection of solid organ transplants
‘Missing self’ is a mode of natural killer (NK) cell activation aimed to detect the lack of HLA-I molecules on infected or neoplastic cells. Here, the authors show that mismatch between donor HLA-I and cognate receptors on recipient NK cells mediates microvascular inflammation-associated graft rejec...
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Nature Portfolio
2019
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oai:doaj.org-article:6e54e790902d416d9bb11f07312515cd2021-12-02T16:58:07ZMissing self triggers NK cell-mediated chronic vascular rejection of solid organ transplants10.1038/s41467-019-13113-52041-1723https://doaj.org/article/6e54e790902d416d9bb11f07312515cd2019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13113-5https://doaj.org/toc/2041-1723‘Missing self’ is a mode of natural killer (NK) cell activation aimed to detect the lack of HLA-I molecules on infected or neoplastic cells. Here, the authors show that mismatch between donor HLA-I and cognate receptors on recipient NK cells mediates microvascular inflammation-associated graft rejection, a pathology that is preventable by mTOR inhibition.Alice KoenigChien-Chia ChenAntoine MarçaisThomas BarbaVirginie MathiasAntoine SicardMaud RabeyrinMaud RacapéJean-Paul Duong-Van-HuyenPatrick BrunevalAlexandre LoupySébastien DussurgeyStéphanie DucreuxVannary Meas-YedidJean-Christophe Olivo-MarinHéléna PaidassiRomain GuillemainJean-Luc TaupinJasper CallemeynEmmanuel MorelonAntonino NicolettiBéatrice CharreauValérie DuboisMaarten NaesensThierry WalzerThierry DefranceOlivier ThaunatNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Alice Koenig Chien-Chia Chen Antoine Marçais Thomas Barba Virginie Mathias Antoine Sicard Maud Rabeyrin Maud Racapé Jean-Paul Duong-Van-Huyen Patrick Bruneval Alexandre Loupy Sébastien Dussurgey Stéphanie Ducreux Vannary Meas-Yedid Jean-Christophe Olivo-Marin Héléna Paidassi Romain Guillemain Jean-Luc Taupin Jasper Callemeyn Emmanuel Morelon Antonino Nicoletti Béatrice Charreau Valérie Dubois Maarten Naesens Thierry Walzer Thierry Defrance Olivier Thaunat Missing self triggers NK cell-mediated chronic vascular rejection of solid organ transplants |
| description |
‘Missing self’ is a mode of natural killer (NK) cell activation aimed to detect the lack of HLA-I molecules on infected or neoplastic cells. Here, the authors show that mismatch between donor HLA-I and cognate receptors on recipient NK cells mediates microvascular inflammation-associated graft rejection, a pathology that is preventable by mTOR inhibition. |
| format |
article |
| author |
Alice Koenig Chien-Chia Chen Antoine Marçais Thomas Barba Virginie Mathias Antoine Sicard Maud Rabeyrin Maud Racapé Jean-Paul Duong-Van-Huyen Patrick Bruneval Alexandre Loupy Sébastien Dussurgey Stéphanie Ducreux Vannary Meas-Yedid Jean-Christophe Olivo-Marin Héléna Paidassi Romain Guillemain Jean-Luc Taupin Jasper Callemeyn Emmanuel Morelon Antonino Nicoletti Béatrice Charreau Valérie Dubois Maarten Naesens Thierry Walzer Thierry Defrance Olivier Thaunat |
| author_facet |
Alice Koenig Chien-Chia Chen Antoine Marçais Thomas Barba Virginie Mathias Antoine Sicard Maud Rabeyrin Maud Racapé Jean-Paul Duong-Van-Huyen Patrick Bruneval Alexandre Loupy Sébastien Dussurgey Stéphanie Ducreux Vannary Meas-Yedid Jean-Christophe Olivo-Marin Héléna Paidassi Romain Guillemain Jean-Luc Taupin Jasper Callemeyn Emmanuel Morelon Antonino Nicoletti Béatrice Charreau Valérie Dubois Maarten Naesens Thierry Walzer Thierry Defrance Olivier Thaunat |
| author_sort |
Alice Koenig |
| title |
Missing self triggers NK cell-mediated chronic vascular rejection of solid organ transplants |
| title_short |
Missing self triggers NK cell-mediated chronic vascular rejection of solid organ transplants |
| title_full |
Missing self triggers NK cell-mediated chronic vascular rejection of solid organ transplants |
| title_fullStr |
Missing self triggers NK cell-mediated chronic vascular rejection of solid organ transplants |
| title_full_unstemmed |
Missing self triggers NK cell-mediated chronic vascular rejection of solid organ transplants |
| title_sort |
missing self triggers nk cell-mediated chronic vascular rejection of solid organ transplants |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/6e54e790902d416d9bb11f07312515cd |
| work_keys_str_mv |
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