Microbiota-directed fibre activates both targeted and secondary metabolic shifts in the distal gut

Microbiota-directed fibre activates both targeted and secondary metabolic shifts in the distal gut

Here, the authors tailor an acetylated galactoglucomannan (AcGGM) fibre from spruce wood to specifically enrich Roseburia and Faecalibacterium - beneficial species which have the enzymatic machinery to breakdown the fibre and generate butyrate. They subsequently perform a piglet feeding trial, metag...

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Bibliographic Details
Main Authors: Leszek Michalak, John Christian Gaby, Leidy Lagos, Sabina Leanti La Rosa, Torgeir R. Hvidsten, Catherine Tétard-Jones, William G. T. Willats, Nicolas Terrapon, Vincent Lombard, Bernard Henrissat, Johannes Dröge, Magnus Øverlie Arntzen, Live Heldal Hagen, Margareth Øverland, Phillip B. Pope, Bjørge Westereng
Format: article
Language:EN
Published: Nature Portfolio 2020
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Science
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Online Access:https://doaj.org/article/6e5fccddd70b4f2492963a10a80b13c2
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Summary:Here, the authors tailor an acetylated galactoglucomannan (AcGGM) fibre from spruce wood to specifically enrich Roseburia and Faecalibacterium - beneficial species which have the enzymatic machinery to breakdown the fibre and generate butyrate. They subsequently perform a piglet feeding trial, metagenomics and metaproteomics, together showing that AcGGM-fed pigs exhibit not only increased Roseburia and Faecalibacterium populations with AcGGM-specific mannan-specific esterases, but also secondary metabolic pathways.

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