Microbiota-directed fibre activates both targeted and secondary metabolic shifts in the distal gut

Here, the authors tailor an acetylated galactoglucomannan (AcGGM) fibre from spruce wood to specifically enrich Roseburia and Faecalibacterium - beneficial species which have the enzymatic machinery to breakdown the fibre and generate butyrate. They subsequently perform a piglet feeding trial, metag...

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Autores principales:	Leszek Michalak, John Christian Gaby, Leidy Lagos, Sabina Leanti La Rosa, Torgeir R. Hvidsten, Catherine Tétard-Jones, William G. T. Willats, Nicolas Terrapon, Vincent Lombard, Bernard Henrissat, Johannes Dröge, Magnus Øverlie Arntzen, Live Heldal Hagen, Margareth Øverland, Phillip B. Pope, Bjørge Westereng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6e5fccddd70b4f2492963a10a80b13c2
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spelling	oai:doaj.org-article:6e5fccddd70b4f2492963a10a80b13c22021-12-02T17:31:25ZMicrobiota-directed fibre activates both targeted and secondary metabolic shifts in the distal gut10.1038/s41467-020-19585-02041-1723https://doaj.org/article/6e5fccddd70b4f2492963a10a80b13c22020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19585-0https://doaj.org/toc/2041-1723Here, the authors tailor an acetylated galactoglucomannan (AcGGM) fibre from spruce wood to specifically enrich Roseburia and Faecalibacterium - beneficial species which have the enzymatic machinery to breakdown the fibre and generate butyrate. They subsequently perform a piglet feeding trial, metagenomics and metaproteomics, together showing that AcGGM-fed pigs exhibit not only increased Roseburia and Faecalibacterium populations with AcGGM-specific mannan-specific esterases, but also secondary metabolic pathways.Leszek MichalakJohn Christian GabyLeidy LagosSabina Leanti La RosaTorgeir R. HvidstenCatherine Tétard-JonesWilliam G. T. WillatsNicolas TerraponVincent LombardBernard HenrissatJohannes DrögeMagnus Øverlie ArntzenLive Heldal HagenMargareth ØverlandPhillip B. PopeBjørge WesterengNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Leszek Michalak John Christian Gaby Leidy Lagos Sabina Leanti La Rosa Torgeir R. Hvidsten Catherine Tétard-Jones William G. T. Willats Nicolas Terrapon Vincent Lombard Bernard Henrissat Johannes Dröge Magnus Øverlie Arntzen Live Heldal Hagen Margareth Øverland Phillip B. Pope Bjørge Westereng Microbiota-directed fibre activates both targeted and secondary metabolic shifts in the distal gut
description	Here, the authors tailor an acetylated galactoglucomannan (AcGGM) fibre from spruce wood to specifically enrich Roseburia and Faecalibacterium - beneficial species which have the enzymatic machinery to breakdown the fibre and generate butyrate. They subsequently perform a piglet feeding trial, metagenomics and metaproteomics, together showing that AcGGM-fed pigs exhibit not only increased Roseburia and Faecalibacterium populations with AcGGM-specific mannan-specific esterases, but also secondary metabolic pathways.
format	article
author	Leszek Michalak John Christian Gaby Leidy Lagos Sabina Leanti La Rosa Torgeir R. Hvidsten Catherine Tétard-Jones William G. T. Willats Nicolas Terrapon Vincent Lombard Bernard Henrissat Johannes Dröge Magnus Øverlie Arntzen Live Heldal Hagen Margareth Øverland Phillip B. Pope Bjørge Westereng
author_facet	Leszek Michalak John Christian Gaby Leidy Lagos Sabina Leanti La Rosa Torgeir R. Hvidsten Catherine Tétard-Jones William G. T. Willats Nicolas Terrapon Vincent Lombard Bernard Henrissat Johannes Dröge Magnus Øverlie Arntzen Live Heldal Hagen Margareth Øverland Phillip B. Pope Bjørge Westereng
author_sort	Leszek Michalak
title	Microbiota-directed fibre activates both targeted and secondary metabolic shifts in the distal gut
title_short	Microbiota-directed fibre activates both targeted and secondary metabolic shifts in the distal gut
title_full	Microbiota-directed fibre activates both targeted and secondary metabolic shifts in the distal gut
title_fullStr	Microbiota-directed fibre activates both targeted and secondary metabolic shifts in the distal gut
title_full_unstemmed	Microbiota-directed fibre activates both targeted and secondary metabolic shifts in the distal gut
title_sort	microbiota-directed fibre activates both targeted and secondary metabolic shifts in the distal gut
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/6e5fccddd70b4f2492963a10a80b13c2
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Microbiota-directed fibre activates both targeted and secondary metabolic shifts in the distal gut

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