Association of Complement-Related Proteins in Subjects With and Without Second Trimester Gestational Diabetes

IntroductionGestational Diabetes Mellitus (GDM) development is related to underlying metabolic syndrome that is associated with elevated complement C3 and C4. Elevated C3 levels have been associated with preeclampsia and the development of macrosomia.MethodsThis case-control study included 34 pregna...

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Autores principales:	Manjunath Ramanjaneya, Alexandra E. Butler, Meis Alkasem, Mohammed Bashir, Jayakumar Jerobin, Angela Godwin, Abu Saleh Md Moin, Lina Ahmed, Mohamed A. Elrayess, Steven C. Hunt, Stephen L. Atkin, Abdul-Badi Abou-Samra
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	complement pregnancy gestational diabetes type 2 diabetes preterm delivery Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/6e6425ca1b774924a703be8f26d9d39a
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spelling	oai:doaj.org-article:6e6425ca1b774924a703be8f26d9d39a2021-11-09T10:16:28ZAssociation of Complement-Related Proteins in Subjects With and Without Second Trimester Gestational Diabetes1664-239210.3389/fendo.2021.641361https://doaj.org/article/6e6425ca1b774924a703be8f26d9d39a2021-03-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.641361/fullhttps://doaj.org/toc/1664-2392IntroductionGestational Diabetes Mellitus (GDM) development is related to underlying metabolic syndrome that is associated with elevated complement C3 and C4. Elevated C3 levels have been associated with preeclampsia and the development of macrosomia.MethodsThis case-control study included 34 pregnant women with GDM and 16 non-diabetic (ND) women in their second trimester. Complement-related proteins were measured and correlated with demographic, biochemical, and pregnancy outcome data.ResultsGDM women were older with a higher BMI (p<0.001); complement C3, C4 and Factor-H were significantly elevated (p=0.001, p=0.05, p=0.01, respectively). When adjusted for age and BMI, Complement C3 (p=0.04) and Factor-H (p=0.04) remained significant. Partial correlation showed significant correlation between C4 with serum alanine aminotransferase (ALT) (p<0.05) and 2nd term diastolic blood pressure (p<0.05); Factor-H and C-reactive protein (CRP; p<0.05). Pearson bivariate analysis revealed significant correlations between C3, C4, and Factor-H and CRP; p<0.05; C3 and gestational age at delivery (GA; p<0.05); C4 and ALT and second-trimester systolic blood pressure (STBP) (p=0.008 and p<0.05, respectively); Factor-H and glycated hemoglobin (HbA1c) (p<0.05). Regression analysis showed that the elevation of C3 could be accounted for by age, BMI, GA and CRP, with CRP being the most important predictor (p=0.02). C4 elevation could be accounted for by ALT, CRP and STBP. CRP predicted Factor-H elevation.ConclusionThe increased C3, C4 and Factor-H during the second trimester of pregnancy in GDM are not independently associated with GDM; inflammation and high BMI may be responsible for their elevation. The elevation of second trimester C3 in GDM is associated with earlier delivery and further work is needed to determine if this is predictive.Manjunath RamanjaneyaManjunath RamanjaneyaAlexandra E. ButlerMeis AlkasemMohammed BashirJayakumar JerobinJayakumar JerobinAngela GodwinAbu Saleh Md MoinLina AhmedMohamed A. ElrayessSteven C. HuntStephen L. AtkinAbdul-Badi Abou-SamraFrontiers Media S.A.articlecomplementpregnancygestational diabetestype 2 diabetespreterm deliveryDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	complement pregnancy gestational diabetes type 2 diabetes preterm delivery Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	complement pregnancy gestational diabetes type 2 diabetes preterm delivery Diseases of the endocrine glands. Clinical endocrinology RC648-665 Manjunath Ramanjaneya Manjunath Ramanjaneya Alexandra E. Butler Meis Alkasem Mohammed Bashir Jayakumar Jerobin Jayakumar Jerobin Angela Godwin Abu Saleh Md Moin Lina Ahmed Mohamed A. Elrayess Steven C. Hunt Stephen L. Atkin Abdul-Badi Abou-Samra Association of Complement-Related Proteins in Subjects With and Without Second Trimester Gestational Diabetes
description	IntroductionGestational Diabetes Mellitus (GDM) development is related to underlying metabolic syndrome that is associated with elevated complement C3 and C4. Elevated C3 levels have been associated with preeclampsia and the development of macrosomia.MethodsThis case-control study included 34 pregnant women with GDM and 16 non-diabetic (ND) women in their second trimester. Complement-related proteins were measured and correlated with demographic, biochemical, and pregnancy outcome data.ResultsGDM women were older with a higher BMI (p<0.001); complement C3, C4 and Factor-H were significantly elevated (p=0.001, p=0.05, p=0.01, respectively). When adjusted for age and BMI, Complement C3 (p=0.04) and Factor-H (p=0.04) remained significant. Partial correlation showed significant correlation between C4 with serum alanine aminotransferase (ALT) (p<0.05) and 2nd term diastolic blood pressure (p<0.05); Factor-H and C-reactive protein (CRP; p<0.05). Pearson bivariate analysis revealed significant correlations between C3, C4, and Factor-H and CRP; p<0.05; C3 and gestational age at delivery (GA; p<0.05); C4 and ALT and second-trimester systolic blood pressure (STBP) (p=0.008 and p<0.05, respectively); Factor-H and glycated hemoglobin (HbA1c) (p<0.05). Regression analysis showed that the elevation of C3 could be accounted for by age, BMI, GA and CRP, with CRP being the most important predictor (p=0.02). C4 elevation could be accounted for by ALT, CRP and STBP. CRP predicted Factor-H elevation.ConclusionThe increased C3, C4 and Factor-H during the second trimester of pregnancy in GDM are not independently associated with GDM; inflammation and high BMI may be responsible for their elevation. The elevation of second trimester C3 in GDM is associated with earlier delivery and further work is needed to determine if this is predictive.
format	article
author	Manjunath Ramanjaneya Manjunath Ramanjaneya Alexandra E. Butler Meis Alkasem Mohammed Bashir Jayakumar Jerobin Jayakumar Jerobin Angela Godwin Abu Saleh Md Moin Lina Ahmed Mohamed A. Elrayess Steven C. Hunt Stephen L. Atkin Abdul-Badi Abou-Samra
author_facet	Manjunath Ramanjaneya Manjunath Ramanjaneya Alexandra E. Butler Meis Alkasem Mohammed Bashir Jayakumar Jerobin Jayakumar Jerobin Angela Godwin Abu Saleh Md Moin Lina Ahmed Mohamed A. Elrayess Steven C. Hunt Stephen L. Atkin Abdul-Badi Abou-Samra
author_sort	Manjunath Ramanjaneya
title	Association of Complement-Related Proteins in Subjects With and Without Second Trimester Gestational Diabetes
title_short	Association of Complement-Related Proteins in Subjects With and Without Second Trimester Gestational Diabetes
title_full	Association of Complement-Related Proteins in Subjects With and Without Second Trimester Gestational Diabetes
title_fullStr	Association of Complement-Related Proteins in Subjects With and Without Second Trimester Gestational Diabetes
title_full_unstemmed	Association of Complement-Related Proteins in Subjects With and Without Second Trimester Gestational Diabetes
title_sort	association of complement-related proteins in subjects with and without second trimester gestational diabetes
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/6e6425ca1b774924a703be8f26d9d39a
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Association of Complement-Related Proteins in Subjects With and Without Second Trimester Gestational Diabetes

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