Diversity-oriented functionalization of 2-pyridones and uracils

Diversity-oriented synthesis of 2-pyridone and uracil derivatives is in urgent need in medicinal chemistry as they are useful pharmacophores. Here the authors show that palladium/norbornene cooperative catalysis enabled dual-functionalization of iodinated 2- pyridones and uracils.

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Autores principales:	Yong Shang, Chenggui Wu, Qianwen Gao, Chang Liu, Lisha Li, Xinping Zhang, Hong-Gang Cheng, Shanshan Liu, Qianghui Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6e648b9aff0148d28469f0aab4b175e1
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spelling	oai:doaj.org-article:6e648b9aff0148d28469f0aab4b175e12021-12-02T15:52:52ZDiversity-oriented functionalization of 2-pyridones and uracils10.1038/s41467-021-23058-32041-1723https://doaj.org/article/6e648b9aff0148d28469f0aab4b175e12021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23058-3https://doaj.org/toc/2041-1723Diversity-oriented synthesis of 2-pyridone and uracil derivatives is in urgent need in medicinal chemistry as they are useful pharmacophores. Here the authors show that palladium/norbornene cooperative catalysis enabled dual-functionalization of iodinated 2- pyridones and uracils.Yong ShangChenggui WuQianwen GaoChang LiuLisha LiXinping ZhangHong-Gang ChengShanshan LiuQianghui ZhouNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yong Shang Chenggui Wu Qianwen Gao Chang Liu Lisha Li Xinping Zhang Hong-Gang Cheng Shanshan Liu Qianghui Zhou Diversity-oriented functionalization of 2-pyridones and uracils
description	Diversity-oriented synthesis of 2-pyridone and uracil derivatives is in urgent need in medicinal chemistry as they are useful pharmacophores. Here the authors show that palladium/norbornene cooperative catalysis enabled dual-functionalization of iodinated 2- pyridones and uracils.
format	article
author	Yong Shang Chenggui Wu Qianwen Gao Chang Liu Lisha Li Xinping Zhang Hong-Gang Cheng Shanshan Liu Qianghui Zhou
author_facet	Yong Shang Chenggui Wu Qianwen Gao Chang Liu Lisha Li Xinping Zhang Hong-Gang Cheng Shanshan Liu Qianghui Zhou
author_sort	Yong Shang
title	Diversity-oriented functionalization of 2-pyridones and uracils
title_short	Diversity-oriented functionalization of 2-pyridones and uracils
title_full	Diversity-oriented functionalization of 2-pyridones and uracils
title_fullStr	Diversity-oriented functionalization of 2-pyridones and uracils
title_full_unstemmed	Diversity-oriented functionalization of 2-pyridones and uracils
title_sort	diversity-oriented functionalization of 2-pyridones and uracils
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6e648b9aff0148d28469f0aab4b175e1
work_keys_str_mv	AT yongshang diversityorientedfunctionalizationof2pyridonesanduracils AT chengguiwu diversityorientedfunctionalizationof2pyridonesanduracils AT qianwengao diversityorientedfunctionalizationof2pyridonesanduracils AT changliu diversityorientedfunctionalizationof2pyridonesanduracils AT lishali diversityorientedfunctionalizationof2pyridonesanduracils AT xinpingzhang diversityorientedfunctionalizationof2pyridonesanduracils AT honggangcheng diversityorientedfunctionalizationof2pyridonesanduracils AT shanshanliu diversityorientedfunctionalizationof2pyridonesanduracils AT qianghuizhou diversityorientedfunctionalizationof2pyridonesanduracils
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Diversity-oriented functionalization of 2-pyridones and uracils

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