Synthesis and preliminary characterization of polyurethane nanoparticles with ginger extract as a possible cardiovascular protector

Florin Borcan,1 Adela Chirita-Emandi,2,3 Nicoleta Ioana Andreescu,2,3 Livia-Cristina Borcan,4 Ramona Carmen Albulescu,5 Maria Puiu,2,3 Mirela Cleopatra Tomescu41The 1st Department (Analytical Chemistry), Faculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy, Tim...

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Autores principales:	Borcan F, Chirita-Emandi A, Andreescu NI, Borcan LC, Albulescu RC, Puiu M, Tomescu MC
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	CD1 Nu/Nu mice drug carrier hollow nanoparticles noxiousness Zeta potential Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6e6493ec043e4923941ce716d72f88ac
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spelling	oai:doaj.org-article:6e6493ec043e4923941ce716d72f88ac2021-12-02T02:34:01ZSynthesis and preliminary characterization of polyurethane nanoparticles with ginger extract as a possible cardiovascular protector1178-2013https://doaj.org/article/6e6493ec043e4923941ce716d72f88ac2019-05-01T00:00:00Zhttps://www.dovepress.com/synthesis-and-preliminary-characterization-of-polyurethane-nanoparticl-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Florin Borcan,1 Adela Chirita-Emandi,2,3 Nicoleta Ioana Andreescu,2,3 Livia-Cristina Borcan,4 Ramona Carmen Albulescu,5 Maria Puiu,2,3 Mirela Cleopatra Tomescu41The 1st Department (Analytical Chemistry), Faculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania; 2The 2nd Department (Genetics), Faculty of Medicine, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania; 3Center of Genomic Medicine, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania; 4The 5th Department (Internal Medicine I), Faculty of Medicine, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania; 5The 11th Department (Pediatrics), Faculty of Medicine, “Victor Babes” University of Medicine and Pharmacy, Timisoara, RomaniaBackground and aim: The extract of ginger, obtained from the rhizome of Zingiber officinale, contains 6-gingerol, 6-shogaol, 8-gingerol, and 10-gingerol. It has many therapeutic effects such as being chemopreventive against stroke and heart diseases, malabsorption, bacterial infections, indigestion, and nausea, which have been observed since ancient times. The main aim of this study is to evaluate the polyurethane (PU) as a proper material for the hollow nanoparticles’ preparation.Methods: The PU nanoparticles were obtained by a spontaneous emulsification, in the presence of a nonionic surfactant, combined with an interfacial polyaddition process between an aliphatic diisocyanate and different mixtures of etheric and esteric polyols. The synthesis was done without any PU additives, such as catalysts, blowing agents, chains promoters, cross-linking agents, and stabilizers.Results: The particles present almost neutral pH values and low water solubility. They are heat resistant up to 280°C. Decreased irritation level was found in the assay of PU nanoparticles loaded with pure ginger extract (GE) on the murine skin tests than the irritation level recorded for pure GE.Conclusion: This research shows the reduced noxiousness of these PU nanoparticles and consequently the possibility of their use as a possible cardiovascular protector.Keywords: CD1 Nu/Nu mice, drug carrier, hollow nanoparticles, noxiousness, Zeta potentialBorcan FChirita-Emandi AAndreescu NIBorcan LCAlbulescu RCPuiu MTomescu MCDove Medical PressarticleCD1 Nu/Nu micedrug carrierhollow nanoparticlesnoxiousnessZeta potentialMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 3691-3703 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	CD1 Nu/Nu mice drug carrier hollow nanoparticles noxiousness Zeta potential Medicine (General) R5-920
spellingShingle	CD1 Nu/Nu mice drug carrier hollow nanoparticles noxiousness Zeta potential Medicine (General) R5-920 Borcan F Chirita-Emandi A Andreescu NI Borcan LC Albulescu RC Puiu M Tomescu MC Synthesis and preliminary characterization of polyurethane nanoparticles with ginger extract as a possible cardiovascular protector
description	Florin Borcan,1 Adela Chirita-Emandi,2,3 Nicoleta Ioana Andreescu,2,3 Livia-Cristina Borcan,4 Ramona Carmen Albulescu,5 Maria Puiu,2,3 Mirela Cleopatra Tomescu41The 1st Department (Analytical Chemistry), Faculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania; 2The 2nd Department (Genetics), Faculty of Medicine, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania; 3Center of Genomic Medicine, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania; 4The 5th Department (Internal Medicine I), Faculty of Medicine, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania; 5The 11th Department (Pediatrics), Faculty of Medicine, “Victor Babes” University of Medicine and Pharmacy, Timisoara, RomaniaBackground and aim: The extract of ginger, obtained from the rhizome of Zingiber officinale, contains 6-gingerol, 6-shogaol, 8-gingerol, and 10-gingerol. It has many therapeutic effects such as being chemopreventive against stroke and heart diseases, malabsorption, bacterial infections, indigestion, and nausea, which have been observed since ancient times. The main aim of this study is to evaluate the polyurethane (PU) as a proper material for the hollow nanoparticles’ preparation.Methods: The PU nanoparticles were obtained by a spontaneous emulsification, in the presence of a nonionic surfactant, combined with an interfacial polyaddition process between an aliphatic diisocyanate and different mixtures of etheric and esteric polyols. The synthesis was done without any PU additives, such as catalysts, blowing agents, chains promoters, cross-linking agents, and stabilizers.Results: The particles present almost neutral pH values and low water solubility. They are heat resistant up to 280°C. Decreased irritation level was found in the assay of PU nanoparticles loaded with pure ginger extract (GE) on the murine skin tests than the irritation level recorded for pure GE.Conclusion: This research shows the reduced noxiousness of these PU nanoparticles and consequently the possibility of their use as a possible cardiovascular protector.Keywords: CD1 Nu/Nu mice, drug carrier, hollow nanoparticles, noxiousness, Zeta potential
format	article
author	Borcan F Chirita-Emandi A Andreescu NI Borcan LC Albulescu RC Puiu M Tomescu MC
author_facet	Borcan F Chirita-Emandi A Andreescu NI Borcan LC Albulescu RC Puiu M Tomescu MC
author_sort	Borcan F
title	Synthesis and preliminary characterization of polyurethane nanoparticles with ginger extract as a possible cardiovascular protector
title_short	Synthesis and preliminary characterization of polyurethane nanoparticles with ginger extract as a possible cardiovascular protector
title_full	Synthesis and preliminary characterization of polyurethane nanoparticles with ginger extract as a possible cardiovascular protector
title_fullStr	Synthesis and preliminary characterization of polyurethane nanoparticles with ginger extract as a possible cardiovascular protector
title_full_unstemmed	Synthesis and preliminary characterization of polyurethane nanoparticles with ginger extract as a possible cardiovascular protector
title_sort	synthesis and preliminary characterization of polyurethane nanoparticles with ginger extract as a possible cardiovascular protector
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/6e6493ec043e4923941ce716d72f88ac
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Synthesis and preliminary characterization of polyurethane nanoparticles with ginger extract as a possible cardiovascular protector

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