Permissive/Protective Interplay of Microbiota with T Cell Adaptive Immune Response in Colon Cancer
Colon microbiota, as a complex and diverse population, has been shown to be either pro- or anti-tumorigenic, depending on itscontent. The composition of microbiota critically determines the differentiation, activation, and expansion of T cells by which prooranti-tumorigenic effects of microbes are f...
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| Autores principales: | , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Shiraz University of Medical Sciences
2016
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/6e65a52e962c465a8802a14cf06827f2 |
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| Sumario: | Colon microbiota, as a complex and diverse population, has been shown to be either pro- or anti-tumorigenic, depending on itscontent. The composition of microbiota critically determines the differentiation, activation, and expansion of T cells by which prooranti-tumorigenic effects of microbes are frequently reported to be mediated. In this review study, we specified an imbalance inmicrobiota and T cells in particular regulatory T cells and Th17 cells in colon cancer. We also aimed to discuss evidence, suggestingthe contribution of microbiota to carcinogenesis or anti-carcinogenesis through influencing T cells. |
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