Permissive/Protective Interplay of Microbiota with T Cell Adaptive Immune Response in Colon Cancer

Colon microbiota, as a complex and diverse population, has been shown to be either pro- or anti-tumorigenic, depending on itscontent. The composition of microbiota critically determines the differentiation, activation, and expansion of T cells by which prooranti-tumorigenic effects of microbes are f...

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Autores principales:	Zahra Mojtahedi, Somayeh Rezaeifard, Zahra Faghih
Formato:	article
Lenguaje:	EN
Publicado:	Shiraz University of Medical Sciences 2016
Materias:	colon cancer microbiota t cells tregs th17 Medicine R
Acceso en línea:	https://doaj.org/article/6e65a52e962c465a8802a14cf06827f2
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spelling	oai:doaj.org-article:6e65a52e962c465a8802a14cf06827f22021-11-15T09:50:14ZPermissive/Protective Interplay of Microbiota with T Cell Adaptive Immune Response in Colon Cancer2783-2430https://doaj.org/article/6e65a52e962c465a8802a14cf06827f22016-12-01T00:00:00Zhttps://colorectalresearch.sums.ac.ir/article_47151_029dc4a07ad6f2e86360efd31127f295.pdfhttps://doaj.org/toc/2783-2430Colon microbiota, as a complex and diverse population, has been shown to be either pro- or anti-tumorigenic, depending on itscontent. The composition of microbiota critically determines the differentiation, activation, and expansion of T cells by which prooranti-tumorigenic effects of microbes are frequently reported to be mediated. In this review study, we specified an imbalance inmicrobiota and T cells in particular regulatory T cells and Th17 cells in colon cancer. We also aimed to discuss evidence, suggestingthe contribution of microbiota to carcinogenesis or anti-carcinogenesis through influencing T cells.Zahra MojtahediSomayeh RezaeifardZahra FaghihShiraz University of Medical Sciencesarticlecolon cancermicrobiotat cellstregsth17MedicineRENIranian Journal of Colorectal Research, Vol 4, Iss 4 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	colon cancer microbiota t cells tregs th17 Medicine R
spellingShingle	colon cancer microbiota t cells tregs th17 Medicine R Zahra Mojtahedi Somayeh Rezaeifard Zahra Faghih Permissive/Protective Interplay of Microbiota with T Cell Adaptive Immune Response in Colon Cancer
description	Colon microbiota, as a complex and diverse population, has been shown to be either pro- or anti-tumorigenic, depending on itscontent. The composition of microbiota critically determines the differentiation, activation, and expansion of T cells by which prooranti-tumorigenic effects of microbes are frequently reported to be mediated. In this review study, we specified an imbalance inmicrobiota and T cells in particular regulatory T cells and Th17 cells in colon cancer. We also aimed to discuss evidence, suggestingthe contribution of microbiota to carcinogenesis or anti-carcinogenesis through influencing T cells.
format	article
author	Zahra Mojtahedi Somayeh Rezaeifard Zahra Faghih
author_facet	Zahra Mojtahedi Somayeh Rezaeifard Zahra Faghih
author_sort	Zahra Mojtahedi
title	Permissive/Protective Interplay of Microbiota with T Cell Adaptive Immune Response in Colon Cancer
title_short	Permissive/Protective Interplay of Microbiota with T Cell Adaptive Immune Response in Colon Cancer
title_full	Permissive/Protective Interplay of Microbiota with T Cell Adaptive Immune Response in Colon Cancer
title_fullStr	Permissive/Protective Interplay of Microbiota with T Cell Adaptive Immune Response in Colon Cancer
title_full_unstemmed	Permissive/Protective Interplay of Microbiota with T Cell Adaptive Immune Response in Colon Cancer
title_sort	permissive/protective interplay of microbiota with t cell adaptive immune response in colon cancer
publisher	Shiraz University of Medical Sciences
publishDate	2016
url	https://doaj.org/article/6e65a52e962c465a8802a14cf06827f2
work_keys_str_mv	AT zahramojtahedi permissiveprotectiveinterplayofmicrobiotawithtcelladaptiveimmuneresponseincoloncancer AT somayehrezaeifard permissiveprotectiveinterplayofmicrobiotawithtcelladaptiveimmuneresponseincoloncancer AT zahrafaghih permissiveprotectiveinterplayofmicrobiotawithtcelladaptiveimmuneresponseincoloncancer
_version_	1718428440794759168

Permissive/Protective Interplay of Microbiota with T Cell Adaptive Immune Response in Colon Cancer

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