Prognosis according to clinical and pathologic lymph node status in breast cancer patients who underwent sentinel lymph node biopsy alone after neoadjuvant therapy.

This study aimed to evaluate the prognosis of breast cancer patients who received neoadjuvant chemotherapy and underwent sentinel lymph node biopsy (SLNB) alone as axillary surgery regardless of their clinical and pathological lymph node status. We reviewed the records of 1,795 patients from Asan Me...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sae Byul Lee, Hakyoung Kim, Jisun Kim, Il Yong Chung, Hee Jeong Kim, Beom Seok Ko, Jong Won Lee, Sei Hyun Ahn, Byung Ho Son
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6e666f05034240098fe4281de7150e0f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6e666f05034240098fe4281de7150e0f
record_format	dspace
spelling	oai:doaj.org-article:6e666f05034240098fe4281de7150e0f2021-11-25T05:54:15ZPrognosis according to clinical and pathologic lymph node status in breast cancer patients who underwent sentinel lymph node biopsy alone after neoadjuvant therapy.1932-620310.1371/journal.pone.0251597https://doaj.org/article/6e666f05034240098fe4281de7150e0f2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0251597https://doaj.org/toc/1932-6203This study aimed to evaluate the prognosis of breast cancer patients who received neoadjuvant chemotherapy and underwent sentinel lymph node biopsy (SLNB) alone as axillary surgery regardless of their clinical and pathological lymph node status. We reviewed the records of 1,795 patients from Asan Medical Center who were diagnosed with stage I-III breast cancer and received neoadjuvant chemotherapy during 2003-2014. We selected 760 patients who underwent SLNB alone as axillary surgery and divided these patients into four groups according to their clinical lymph node (cN) and pathological lymph node (pN) status: cN(-)pN(-) (n = 377), cN(-)pN(+) (n = 33), cN(+)pN(-) (n = 242), and cN(+)pN(+) (n = 108). We then compared axillary lymph node recurrence, locoregional recurrence (LRR), distant metastasis-free survival (DMFS), and overall survival (OS) among the four groups using Kaplan-Meier analysis. We compared prognosis between the cN(-)pN(-) and cN(+)pN(-) groups to determine whether SLNB alone is an adequate treatment modality even in patients with cN positive pathology before neoadjuvant therapy but SLNB-negative pathology after NAC. The 5-year axillary recurrence rates in the cN(-)pN(-) and cN(+)pN(-) groups were 1.4% and 2.9%, respectively, and there was no significant difference between the two groups (p = 0.152). The axillary recurrence and LRR rates were significantly different among the four groups, with the pN-negative groups (cN[-]pN[-], cN[+]pN[-]) showing lower recurrence rates. DMFS and OS were also significantly different among the four groups, with the cN negative groups (cN[-]pN[-], cN[-]pN[+]) showing improved survival rates. Our study findings suggest that SLNB alone was associated with lower LRR rates even in patients with cN positive pathology before neoadjuvant therapy but cN negative pathology after SLNB. Moreover, recurrence and survival rates differ significantly according to clinical and pathological lymph node status.Sae Byul LeeHakyoung KimJisun KimIl Yong ChungHee Jeong KimBeom Seok KoJong Won LeeSei Hyun AhnByung Ho SonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 5, p e0251597 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sae Byul Lee Hakyoung Kim Jisun Kim Il Yong Chung Hee Jeong Kim Beom Seok Ko Jong Won Lee Sei Hyun Ahn Byung Ho Son Prognosis according to clinical and pathologic lymph node status in breast cancer patients who underwent sentinel lymph node biopsy alone after neoadjuvant therapy.
description	This study aimed to evaluate the prognosis of breast cancer patients who received neoadjuvant chemotherapy and underwent sentinel lymph node biopsy (SLNB) alone as axillary surgery regardless of their clinical and pathological lymph node status. We reviewed the records of 1,795 patients from Asan Medical Center who were diagnosed with stage I-III breast cancer and received neoadjuvant chemotherapy during 2003-2014. We selected 760 patients who underwent SLNB alone as axillary surgery and divided these patients into four groups according to their clinical lymph node (cN) and pathological lymph node (pN) status: cN(-)pN(-) (n = 377), cN(-)pN(+) (n = 33), cN(+)pN(-) (n = 242), and cN(+)pN(+) (n = 108). We then compared axillary lymph node recurrence, locoregional recurrence (LRR), distant metastasis-free survival (DMFS), and overall survival (OS) among the four groups using Kaplan-Meier analysis. We compared prognosis between the cN(-)pN(-) and cN(+)pN(-) groups to determine whether SLNB alone is an adequate treatment modality even in patients with cN positive pathology before neoadjuvant therapy but SLNB-negative pathology after NAC. The 5-year axillary recurrence rates in the cN(-)pN(-) and cN(+)pN(-) groups were 1.4% and 2.9%, respectively, and there was no significant difference between the two groups (p = 0.152). The axillary recurrence and LRR rates were significantly different among the four groups, with the pN-negative groups (cN[-]pN[-], cN[+]pN[-]) showing lower recurrence rates. DMFS and OS were also significantly different among the four groups, with the cN negative groups (cN[-]pN[-], cN[-]pN[+]) showing improved survival rates. Our study findings suggest that SLNB alone was associated with lower LRR rates even in patients with cN positive pathology before neoadjuvant therapy but cN negative pathology after SLNB. Moreover, recurrence and survival rates differ significantly according to clinical and pathological lymph node status.
format	article
author	Sae Byul Lee Hakyoung Kim Jisun Kim Il Yong Chung Hee Jeong Kim Beom Seok Ko Jong Won Lee Sei Hyun Ahn Byung Ho Son
author_facet	Sae Byul Lee Hakyoung Kim Jisun Kim Il Yong Chung Hee Jeong Kim Beom Seok Ko Jong Won Lee Sei Hyun Ahn Byung Ho Son
author_sort	Sae Byul Lee
title	Prognosis according to clinical and pathologic lymph node status in breast cancer patients who underwent sentinel lymph node biopsy alone after neoadjuvant therapy.
title_short	Prognosis according to clinical and pathologic lymph node status in breast cancer patients who underwent sentinel lymph node biopsy alone after neoadjuvant therapy.
title_full	Prognosis according to clinical and pathologic lymph node status in breast cancer patients who underwent sentinel lymph node biopsy alone after neoadjuvant therapy.
title_fullStr	Prognosis according to clinical and pathologic lymph node status in breast cancer patients who underwent sentinel lymph node biopsy alone after neoadjuvant therapy.
title_full_unstemmed	Prognosis according to clinical and pathologic lymph node status in breast cancer patients who underwent sentinel lymph node biopsy alone after neoadjuvant therapy.
title_sort	prognosis according to clinical and pathologic lymph node status in breast cancer patients who underwent sentinel lymph node biopsy alone after neoadjuvant therapy.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/6e666f05034240098fe4281de7150e0f
work_keys_str_mv	AT saebyullee prognosisaccordingtoclinicalandpathologiclymphnodestatusinbreastcancerpatientswhounderwentsentinellymphnodebiopsyaloneafterneoadjuvanttherapy AT hakyoungkim prognosisaccordingtoclinicalandpathologiclymphnodestatusinbreastcancerpatientswhounderwentsentinellymphnodebiopsyaloneafterneoadjuvanttherapy AT jisunkim prognosisaccordingtoclinicalandpathologiclymphnodestatusinbreastcancerpatientswhounderwentsentinellymphnodebiopsyaloneafterneoadjuvanttherapy AT ilyongchung prognosisaccordingtoclinicalandpathologiclymphnodestatusinbreastcancerpatientswhounderwentsentinellymphnodebiopsyaloneafterneoadjuvanttherapy AT heejeongkim prognosisaccordingtoclinicalandpathologiclymphnodestatusinbreastcancerpatientswhounderwentsentinellymphnodebiopsyaloneafterneoadjuvanttherapy AT beomseokko prognosisaccordingtoclinicalandpathologiclymphnodestatusinbreastcancerpatientswhounderwentsentinellymphnodebiopsyaloneafterneoadjuvanttherapy AT jongwonlee prognosisaccordingtoclinicalandpathologiclymphnodestatusinbreastcancerpatientswhounderwentsentinellymphnodebiopsyaloneafterneoadjuvanttherapy AT seihyunahn prognosisaccordingtoclinicalandpathologiclymphnodestatusinbreastcancerpatientswhounderwentsentinellymphnodebiopsyaloneafterneoadjuvanttherapy AT byunghoson prognosisaccordingtoclinicalandpathologiclymphnodestatusinbreastcancerpatientswhounderwentsentinellymphnodebiopsyaloneafterneoadjuvanttherapy
_version_	1718414406953467904

Prognosis according to clinical and pathologic lymph node status in breast cancer patients who underwent sentinel lymph node biopsy alone after neoadjuvant therapy.

Ejemplares similares