The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells

In meiosis, BRCA2 associates to MEILB2 localising at DNA double-strand breaks (DSBs). Here, the authors identify BRCA2 and MEILB2- associating protein 1 termed BRME1 to work together in regulating meiotic recombination.

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Autores principales:	Jingjing Zhang, Manickam Gurusaran, Yasuhiro Fujiwara, Kexin Zhang, Meriem Echbarthi, Egor Vorontsov, Rui Guo, Devon F. Pendlebury, Intekhab Alam, Gabriel Livera, Martini Emmanuelle, P. Jeremy Wang, Jayakrishnan Nandakumar, Owen R. Davies, Hiroki Shibuya
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6e679d2b3eb24e0c874ec41bdc538df0
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spelling	oai:doaj.org-article:6e679d2b3eb24e0c874ec41bdc538df02021-12-02T17:31:25ZThe BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells10.1038/s41467-020-15954-x2041-1723https://doaj.org/article/6e679d2b3eb24e0c874ec41bdc538df02020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15954-xhttps://doaj.org/toc/2041-1723In meiosis, BRCA2 associates to MEILB2 localising at DNA double-strand breaks (DSBs). Here, the authors identify BRCA2 and MEILB2- associating protein 1 termed BRME1 to work together in regulating meiotic recombination.Jingjing ZhangManickam GurusaranYasuhiro FujiwaraKexin ZhangMeriem EchbarthiEgor VorontsovRui GuoDevon F. PendleburyIntekhab AlamGabriel LiveraMartini EmmanuelleP. Jeremy WangJayakrishnan NandakumarOwen R. DaviesHiroki ShibuyaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jingjing Zhang Manickam Gurusaran Yasuhiro Fujiwara Kexin Zhang Meriem Echbarthi Egor Vorontsov Rui Guo Devon F. Pendlebury Intekhab Alam Gabriel Livera Martini Emmanuelle P. Jeremy Wang Jayakrishnan Nandakumar Owen R. Davies Hiroki Shibuya The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells
description	In meiosis, BRCA2 associates to MEILB2 localising at DNA double-strand breaks (DSBs). Here, the authors identify BRCA2 and MEILB2- associating protein 1 termed BRME1 to work together in regulating meiotic recombination.
format	article
author	Jingjing Zhang Manickam Gurusaran Yasuhiro Fujiwara Kexin Zhang Meriem Echbarthi Egor Vorontsov Rui Guo Devon F. Pendlebury Intekhab Alam Gabriel Livera Martini Emmanuelle P. Jeremy Wang Jayakrishnan Nandakumar Owen R. Davies Hiroki Shibuya
author_facet	Jingjing Zhang Manickam Gurusaran Yasuhiro Fujiwara Kexin Zhang Meriem Echbarthi Egor Vorontsov Rui Guo Devon F. Pendlebury Intekhab Alam Gabriel Livera Martini Emmanuelle P. Jeremy Wang Jayakrishnan Nandakumar Owen R. Davies Hiroki Shibuya
author_sort	Jingjing Zhang
title	The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells
title_short	The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells
title_full	The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells
title_fullStr	The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells
title_full_unstemmed	The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells
title_sort	brca2-meilb2-brme1 complex governs meiotic recombination and impairs the mitotic brca2-rad51 function in cancer cells
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/6e679d2b3eb24e0c874ec41bdc538df0
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The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells

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